Articles tagged "Liver transplantation"

2021 American Transplant Congress
The Confluence of Race, Socioeconomic Deprivation, and Waitlist Mortality for Children Awaiting Liver Transplant
S. Wadhwani¹, J. Ge¹, L. Gottlieb¹, C. Lyles¹, A. F. Beck², J. Bucuvalas³, U. Kotagal², J. C. Lai¹
¹University of California San Francisco, San Francisco, CA, ²Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Social determinants like racism, ethnocentrism, and neighborhood socioeconomic deprivation are associated with poor outcomes for children after liver transplant. We studied the relationship between…
2021 American Transplant Congress
Primary Outcome of OPTIMAL: A Prospective Multicenter Trial of Immunosuppression Withdrawal (ISW) in Stable Adult Liver Transplant (LT) Recipients
S. Chandran¹, K. Mason², L. F. Sun¹, N. Tanimine³, M. DesMarais¹, B. Burrell¹, J. F. Markmann³
¹ITN, San Francisco, CA, ²Rho, Inc., Durham, NC, ³MGH, Boston, MA
*Purpose: To identify clinical & mechanistic correlates of successful ISW and operational tolerance (OT) in a selected cohort of adult LT recipients.*Methods: The Immune Tolerance…
2021 American Transplant Congress
Myeloid Yap Signaling is Required for Hepatic Cytoprotection in Liver Ischemia-reperfusion Injury
B. Yang¹, Z. Xue¹, C. Zhang², Y. Zhang², Y. Liu², J. Kupiec-Weglinski¹, H. Ji¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²Dept of Surgery, Zhejiang University, Hangzhou, China
*Purpose: Liver ischemia-reperfusion injury (IRI) is recognized as an innate immunity-driven local inflammation response during hemorrhagic shock, liver resection and transplantation. Yes-associate protein 1 (YAP)…
2021 American Transplant Congress
COVID-19 Infection in Kidney versus Non-kidney Solid Organ Transplant Recipients: A Single Center Study
J. Schaenman¹, H. Byford², T. R. Grogan³, S. Fraschilla², K. Meneses⁴, J. C. Alejos⁵, M. Rivera⁶, S. Saab⁷
¹Infectious Diseases, UCLA, Los Angeles, CA, ²Transplant Administration, UCLA, Los Angeles, CA, ³Division of General Internal Medicine and Health Services Research, UCLA, Los Angeles, CA, ⁴Liver Transplantation, UCLA, Los Angeles, CA, ⁵Pediatric Heart Transplantation, UCLA, Los Angeles, CA, ⁶Pediatric Kidney Transplantation, UCLA, Los Angeles, CA, ⁷Liver Transplantation, David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: The COVID-19 pandemic has caused significant morbidity and mortality in patients around the world. A significant impact has been observed in immunocompromised patients such…
2021 American Transplant Congress
Blood Pressure Variability Immediately After Liver Transplant Predicts the Likelihood of Long-Term Cardiovascular Events
K. N. Truitt¹, K. Chen², Y. Yano³, D. Gregory⁴, L. B. VanWagner⁵
¹Northwestern Memorial Hospital, Chicago, IL, ²Harvard University, Cambridge, MA, ³Duke University School of Medicine, Durham, NC, ⁴Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Northwestern University Feinberg School of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: Cardiovascular disease is a leading cause of mortality in liver transplant recipients (LTRs). Adequate blood pressure (BP) control within one year after liver transplant…
2021 American Transplant Congress
Impact of Donation After Circulatory Death Donor Allografts on Outcomes Following Liver Transplantation for Cholangiocarcinoma
S. Kumar¹, S. Lin², J. D. Schold²
¹Digestive Disease Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates, ²Department of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH
*Purpose: Improvements in the management of extra-hepatic cholangiocarcinoma (CCA) resulted in allocation of a standardized model for end-stage liver disease (MELD) exception score for liver…
2021 American Transplant Congress
Waitlist Outcomes for Exception Candidates Following the Implementation of MMaT/250 Score
T. Ishaque¹, J. G. Wang¹, S. Karhadkar², D. Segev¹, A. B. Massie¹
¹Johns Hopkins Medical Institutions, Baltimore, MD, ²Temple University, Philadelphia, PA
*Purpose: Starting in May 2019, exception points were allocated based on DSA-level median-MELD-at-transplant (MMaT/DSA). In February 2020, the exception point system was further modified based…
2021 American Transplant Congress
Comparison of Outcomes of Living Donor Liver Transplantation for Biliary Atresia Patients with and without Kasai Portoenterostomy
T. Kanmaz¹, O. Andacoglu¹, Y. Yankol², C. Karatas¹, N. Mecit¹, K. Acarli³, M. Kalayoglu¹
¹Koc University, Istanbul, Turkey, ²University of Wisconsin, Madison, WI, ³Memorial Hospital, Istanbul, Turkey
*Purpose: We evaluated 10 year outcomes and the potential predictors of outcomes after living donor liver transplant (LT) for biliary atresia (BA) patients with and…
2021 American Transplant Congress
Mortality, Risk Factors, and Treatment of Covid-19 Infection in Solid Organ Transplants: A Systematic Review and Meta-analysis
S. Yin, T. Song, Q. Zhong, T. Lin
Urology Institute and Organ Transplantation Center, West China Hospital, Chengdu, China
*Purpose: Outcomes for solid organ transplants (SOT) with COVID-19 have not been summarized, and prognostic factors for COVID-19 in SOT patients are not well established…
2021 American Transplant Congress
Systematic Implementation of Alcohol Screening Program Using Urine Ethyl Glucuronide Can Identify Post-transplant Alcohol Use and Aid Return to Sobriety in Liver Transplant Recipients
N. Lim¹, T. Leventhal¹, M. Thomson¹, M. Hassan¹, J. Thompson¹, S. Chinnakotla², V. Kirchner², T. Pruett¹, R. Kandaswamy², V. Humphreville², A. Adams², J. Lake¹
¹Division of Gastroenterology, Hepatology and Nutrition, University of Minnesota, Minneapolis, MN, ²Division of Transplantation, University of Minnesota, Minneapolis, MN
*Purpose: Rates of liver transplantation (LT) for alcohol-related liver disease (ALD) are increasing, particularly in patients with acute alcoholic hepatitis. Post-LT alcohol (ETOH) use has…