Articles tagged "Liver transplantation"

2022 American Transplant Congress
Molecular Characterization of the Plasma Secretome in Pediatric Liver Transplantation (pLTx) Identified Cytokine/Chemokine Signatures Potentially Linked to Beneficial Immunosuppressive Regimes (IS) and Recovery
E. Chichelnitskiy¹, L. Ruhl², I. Goldschmidt³, A. Karch⁴, L. Antiga⁵, D. Debray⁶, L. Hierro⁷, D. Kelly⁸, V. McLin⁹, E. Nicastro¹⁰, J. Pawlowska¹¹, P. Czubkowski¹¹, R. Mikolajczyk¹², U. Baumann¹³, C. Falk¹⁴
¹Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, ²Institute of Transplant Immunology, MHH, Hannover, Germany, ³Division of Pediatric Gastroenterology and Hepatology, MHH; European Paediatric Liver Transplantation Network, Hannover, Germany, ⁴Research Group Epidemiological and Statistical Methods, Helmholtz Centre for Infection Research, Braunschweig; German Center for Infection Research, TTU-IICH Hannover;Institute for Epidemiology and Social Medicine, University of Münster, Münster, Germany, ⁵Ospedali Riuniti di Bergamo, Bergamo, Italy, ⁶Hôpital Necker-Enfants Malades, Paris, France, ⁷Hospital Infantil Universitario La Paz, Madrid, Spain, ⁸Birmingham Childrens Hosp, Birmingham, United Kingdom, ⁹Service Spécialités Pédiatriques, Genève, Switzerland, ¹⁰Pediatric Hepatology, Gastroenterology and Transplantation, Hospital Papa Giovanni XXIII, Bergamo, Italy, ¹¹Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children’s Memorial Health Institute, Warsaw, Poland, ¹²Institute of Medical Epidemiology, Biostatistics and Medical Informatics, University of Halle; German Center for Infection Research, TTU-IICH Hannover; MHH, Halle, Germany, ¹³Division of Pediatric Gastroenterology and Hepatology, MHH; Birmingham Children’s Hospital, UK, Hannover, Germany, ¹⁴Institute of Transplant Immunology, MHH; German Center for Infection Research, TTU-IICH, Hannover, Germany
*Purpose: In the European multicentre “ChilSFree” study we aimed to characterize longitudinal dynamics of soluble immune mediators during the first year after pLTx.*Methods: Using Luminex-based…
2022 American Transplant Congress
Impact and Consequences of Recipient Gastroduodenal Artery (GDA) Ligation Prior to Hepatic Artery (HA) Anastomosis During Orthotopic Liver Transplantation (OLT)
A. Kumar, D. Gerber, C. Desai
Abdominal Transplant Surgery, UNC School of Medicine, Chapel Hill, NC
*Purpose: The recipient GDA is often ligated before the HA anastomosis during OLT either to gain mobility, length on recipient HA and with hypothesis that…
2022 American Transplant Congress
Integrated Alcohol Use Disorder Clinic as a Strategy to Reduce Alcohol Relapse After Early Liver Transplantation in Patients with Alcohol Related Liver Disease
R. Z. Syed¹, C. Albers², N. Kemmer², V. Subramanian², C. Machado-Denis¹, K. Dhanireddy²
¹Hepatology and Liver Transplantation, Tampa General Hospital, Tampa, FL, ²Tampa General Hospital, Tampa, FL
*Purpose: In recent years, for patients with Alcohol related Liver Disease (ALD), there has been a trend towards early Liver Transplantation (LT) rather than waiting…
2022 American Transplant Congress
Tracheostomy After Liver Transplantation: Utility and Impact
D. Noguchi, V. M. Nguyen, C. J. Rosenthal, V. G. Agopian, D. G. Farmer, F. M. Kaldas
Liver and Pancreas Transplant Center, UCLA, Los Angeles, CA
*Purpose: High acuity Liver transplant (LT) patients have an increased risk of postoperative respiratory failure requiring tracheostomy (TS). The use of TS in ventilator-dependent patients…
2022 American Transplant Congress
Safety and Efficacy of Glucagon-Like Peptide-1 Receptor Agonists in Solid Organ Transplant
H. Sweiss¹, D. Zeilmann¹, J. Escamilla², R. Hall¹, S. Bhayana¹, R. Patel¹, C. Long²
¹University Health - University Hospital, San Antonio, TX, ²College of Pharmacy, University of Incarnate Word, San Antonio, TX
*Purpose: To evaluate the safety and efficacy of glucagon-like peptide-1 receptor agonists (GLP1-RA) in solid organ transplant (SOT).*Methods: This retrospective review included adult kidney, liver,…
2022 American Transplant Congress
Impact of HMGB-1 SNPs on Comorbidities and Postoperative Complications in Liver Transplant Recipients
N. Tsukiyama¹, Y. Tanaka¹, Y. Imaoka¹, A. Seidakhmetov¹, R. Nakano¹, N. Tanimine¹, D. Marlen¹, M. Ohira², H. Tahara¹, K. Ide¹, H. Ohdan¹
¹Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan, ²Hiroshima University, Hiroshima, Japan
*Purpose: High-mobility group box 1 (HMGB-1) is an inflammatory mediator which becomes an uncontrollable lethal factor when released in excess from the nucleus or the…
2021 American Transplant Congress
Outcomes of Liver Transplantation for Combined Hepatocellular Cholangiocarcinoma: A Single-center Experience
Y. Liu¹, C. Hanlon¹, S. Zhou¹, D. Toy¹, K. King², K. Zhou³, J. Kahn³, L. Yuan³
¹Internal Medicine, USC Keck School of Medicine, Los Angeles, CA, ²Radiology, USC Keck School of Medicine, Los Angeles, CA, ³Internal Medicine - Gastrointestinal and Liver Disease, USC Keck School of Medicine, Los Angeles, CA
*Purpose: Combined hepatocellular cholangiocarcinoma (cHCC-CCA) is a hepatic tumor that exhibits histological features of both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). cHCC-CCA is often diagnosed…
2021 American Transplant Congress
Liver Simulated Allocation Model Does Not Accurately Predict Organ Offer Decisions in Pediatric Liver Transplant Candidates
N. L. Wood¹, D. B. Mogul², E. K. Hsu³, E. R. Perito⁴, G. V. Mazariegos⁵, D. Vanderwerken¹, D. L. Segev², S. Gentry¹
¹US Naval Academy, Annapolis, MD, ²Johns Hopkins, Baltimore, MD, ³Univ of Washington, Seattle, WA, ⁴UCSF, San Francisco, CA, ⁵Univ of Pittsburgh, Pittsburgh, PA
*Purpose: The U.S. relies on the Scientific Registry of Transplant Recipient’s (SRTR’s) Liver Simulated Allocation Model (LSAM) to predict the effect of allocation policy changes…
2021 American Transplant Congress
The Utility of PET/ CT Testing in Cardiac Risk Stratification of Adult Liver Transplant Candidates
M. A. Tincopa¹, R. Weinberg¹, S. Sengupta¹, J. Slivnick², J. Corbett¹, C. Sonnenday¹, R. Fontana¹, P. Sharma¹
¹Internal Medicine, University of Michigan, Ann Arbor, MI, ²Internal Medicine, Ohio State University, Columbus, OH
*Purpose: Optimal cardiovascular (CV) risk stratification in liver transplant (LT) candidates remains unclear. The aim of this study was to assess concordance and utility of…
2021 American Transplant Congress
Hepatocyte SIRT1 Suppresses Atf4-mediated Apoptosis Triggered by Cold Stress in Mouse and Human Liver Transplantation
K. Kadono¹, H. Hirao¹, H. Kojima¹, K. J. Dery¹, J. Aziz¹, X. Li², J. W. Kupiec-Weglinski¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²NIEHS, Durham, NC
*Purpose: The role of ER-stress or hepatocyte-specific SIRT1 signaling during donor liver cold preservation remains unknown. We employed a mouse OLT model and analyzed clinical…