ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Liver transplantation"

  • 2015 American Transplant Congress

    Impact of Donor Post-Extubation O2 Delivery on Recipient Hypoxic Cholangiopathy in Donation After Circulatory Death Liver Transplantation: The University of Colorado Experience

    T. Chirichella,1 C. Dunham,2 M. Zimmerman,4 K. Conzen,1 S. Kelley,3 E. Phelan,1 T. Steinberg,1 T. Nydam,1 T. Bak,1 I. Kam,1 M. Wachs.1

    1Transplant Surgery, University of Colorado Hospital, Aurora, CO; 2Department of Surgery, St. Elizabeth Health Center, Youngstown, OH; 3Donor Alliance Organ Procurement Organization, Denver, CO; 4Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI.

    The critical shortage of deceased organ donors has led to increased utilization of DCD liver grafts. The purpose of this study was to evaluate DCD…
  • 2015 American Transplant Congress

    Ischemia Reperfusion Injury in Orthotopic Liver Transplantation Primes the Adaptive Immune Response and Generation of Proinflammatory Cytokines

    A. Zarrinpar,1 P. Rao,2 C. Lassman,2 V. Agopian,1 F. Kaldas,1 D. Farmer,1 R. Busuttil,1 Y. Zhai,1 J. Kupiec-Weglinski,1 E. Reed.2

    1Surgery, University of California, Los Angeles, Los Angeles, CA; 2Pathology and Lab Medicine, University of California, Los Angeles, Los Angeles, CA.

    Background: Transplanted organs are exquisitely susceptible to effects of ischemia/reperfusion injury (IRI), an immune-mediated process that occurs during transplantation and beyond. Recipient and graft outcomes,…
  • 2015 American Transplant Congress

    Long-Term Survival Outcomes of Liver Transplantation for Klatskin Tumour: A Comparative Study With Radical Resection Surgery

    A. Hu, X. Zhu, X. He.

    Department of general Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

    Background and aim: Besides radical resection (RR), Liver transplantation (LT) is another suggested surgical modality for hilar cholangiocarcinoma (Klatskin tumour, KT) especially for patients whose…
  • 2015 American Transplant Congress

    Standardizing Quality Improvement Practices in Pediatric Liver Transplantation: The SPLIT A3 Project

    B. Kelly,1 R. Himes,2 J. Bucuvalas,3 L. Ware,1 S. Horslen.4

    1Surgery, Children's Hospital Pittsburgh, Pittsburgh, PA; 2Pediatrics, Texas Children's Hospital, Houston, TX; 3Pediatrics, Cincinnati Children's Hospital, Cincinnati, OH; 4Pediatrics, Seattle Children's Hospital, Seattle, WA; 5The Studies of Pediatric Liver Transplantation, EMMES Corporation, Maryland.

    Quality improvement (QI) programs are key drivers of continual reform in process and patient safety, but at present, there are no pediatric liver transplant (PLT)-specific…
  • 2015 American Transplant Congress

    Changes in Utilization, Discard, and Outcomes Associated With Hepatitis C (+) Donor Livers in the Era of Direct Acting Anti-Retroviral Therapy

    M. Bowring, L. Kucirka, X. Luo, A. Massie, D. Segev, C. Durand.

    Johns Hopkins University, Baltimore, MD.

    While 45% of liver candidates are hepatitis C (HCV) (+) and might benefit from an HCV (+) donor liver, only 7.1% receive one, and HCV…
  • 2015 American Transplant Congress

    Everolimus and Early Calcineurin Inhibitor Withdrawal Is Associated With Superior Renal Function: 5-Year Follow-Up of the Randomized PROTECT Liver Transplantation Study

    M. Sterneck, G. Kaiser, N. Heyne, N. Richter, F. Rauchfuss, A. Pascher, P. Schemmer, L. Fischer, C. Klein, S. Nadalin, F. Lehner, U. Settmacher, D. Gotthardt, M. Loss, S. Ladenburger, P. Wimmer, M. Dworak, H. Schlitt.

    PROTECT Study Group, Novartis Pharma GmbH, Germany.

    Purpose: At the end of the 12-month (M) PROTECT core study (NCT00378014), de novo liver transplant recipients (LTxR) who switched from a calcineurin inhibitor (CNI)…
  • 2015 American Transplant Congress

    Hypothermic Machine Preservation Reduces Inflammatory, Hypoxic and Apoptotic Injuries in Human Liver Transplantation

    J. Guarrera, C. Bae, S. Henry.

    Center for Liver Disease and Transplantation, Columbia University Medical Center, New York, NY.

    Introduction: Hypothermic machine perfusion (HMP) is in its infancy in Liver Transplantation. We analyzed all molecular samples from our cumulative clinical experience at Columbia University.Methods:…
  • 2015 American Transplant Congress

    Efficacy and Safety of Once-Daily Everolimus With Minimized Once-Daily Tacrolimus After Liver Transplantation

    P. De Simone,1 P. Carrai,1 L. Coletti,1 A. Precisi,2 D. Campani,3 F. Filipponi.1

    1Hepatobiliary Surgery and Liver Transplantation, University of Pisa Medical School Hospital, Pisa, Italy; 2Laboratory, University of Pisa Medical School Hospital, Pisa, Italy; 3Pathology, University of Pisa Medical School Hospital, Pisa, Italy.

    Background: The everolimus (EVR) pharmacokinetic profile allows for its once daily (OD) administration. We tested the efficacy and safety of a combination schedule of OD-EVR…
  • 2015 American Transplant Congress

    Hospital Characteristics Mediate Variation in Cirrhosis Mortality in Transplant and Non-Transplant Facilities

    A. Mathur,1 A. Chakrabarti,2 K. Sheetz,2 J. Mellinger,3 M. Volk,3 N. Katariya,1 A. Singer,1 W. Hewitt,1 K. Reddy,1 A. Moss.1

    1Surgery, Mayo Clinic Arizona, Phoenix, AZ; 2Surgery, University of Michigan, Ann Arbor, MI; 3Medicine, University of Michigan, Ann Arbor, MI.

    Hospitals vary significantly in cirrhosis mortality. We aimed to determine whether hospital structural characteristics mediate this effect.Methods: We used 2009 data from the HCUP Nationwide…
  • 2015 American Transplant Congress

    Renal Function Difference Between Anti-Hepatitis B Immunoglobulin(HBIG) Monotherapy and HBIG Combined With Entecavir in Liver Recipients

    J. Lee,1,2 J. Lee,1,2 J. Lee,3 M. Kim,1,2 M. Ju,1,2 G. Choi,1,2 J. Choi,1,2 S. Kim,1,2 D. Joo.1,2

    1Department of Transplantation Surgery, Severance Hospital, Yonsei University Health System, Seroul, Korea; 2Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea; 3Department of Surgery, CHA Bundang Medical Center, CHA University, Bundang, Korea.

    Background: To reduce the HBV reinfection after liver transplantation, anti-hepatitis B immunoglobulin (HBIG) alone or combination with antiviral nucleotide analogues are usually used regimen. However,…
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