ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Liver transplantation"

  • 2015 American Transplant Congress

    Normothemic Machine Perfusion of Liver Grafts Promotes Liver Regeneration and Inhibits Tissue Inflammation

    E. Xystrakis, J. Lozano, R. Danger, M. Martinez-Llordella, P. Srinivasan, N. Heaton, C. Coussios, A. Sanchez-Fueyo, Y. Ma, W. Jassem.

    Institute of Liver Studies, King's College London School of Medicine at King's College Hospital, London, United Kingdom; Plataforma de Bioinformatica, Centro de Investigación Biomédica en red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Hospital Clinic, Centre Esther Koplovitz (CEK), Barcelona, Spain; Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom.

    Background & aim: liver transplantation I/R injury is associated with inflammation, affecting graft outcome. Ex-vivo normothermic machine perfusion (NMP) to donor livers before transplantation reduces…
  • 2015 American Transplant Congress

    The Effect of Preformed and De Novo Donor-Specific Antibodies (DSA) in Acute Rejection (AR) After Liver Transplantation (LTX)

    M. Koch,1 M. Runnebaum,1 M. Goebel,2 H. Thude,1 M. Sterneck,1 M. Marget,2 B. Nashan.1

    1Hepatobiliary Surgery and Transplantation, University Medical Centre, Hamburg, Germany; 2HLA-Laboratory, University Medical Centre, Hamburg, Germany.

    BACKGROUND: The role of preformed and den novo formed DSA in LTX is not fully revealed. The aim of our study was to determine if…
  • 2015 American Transplant Congress

    Financial Impact of an Advanced Liver Disease Service on a Tertiary Health System

    A. Masoumi,1 S. Hanish,2 J. LaMattina,2 C. Njoka,1 W. Hutson,2 D. Potosky,2 R. Barth.2

    1University of Maryland Medical Center, Baltimore; 2University of Maryland School of Medicine, Baltimore.

    Regional disparities in liver transplantation motivated revision of national organ-sharing policies towards critically ill patients. Liver transplantation of high MELD patients incorporates significant institutional commitment…
  • 2015 American Transplant Congress

    The Product of Donor Age and Preoperative MELD, D-MELD, Predicts Surgical Outcomes After LDLT, When Using Small Graft

    A. Tanemura, S. Mizuno, H. Kato, Y. Murata, N. Kuriyama, Y. Azumi, M. Kishiwada, M. Usui, H. Sakurai, S. Isaji.

    Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu, Japan.

    Background:Donor-recipient match is recognized as the factor well predicting recipient outcome in deceased donor liver transplantation. The aim of the present study is to evaluate…
  • 2015 American Transplant Congress

    Historical Comparison of Projected and Observed Liver Transplants

    J. Pyke,1 D. Schladt,1 W. Kim,5 S. Leppke,1 J. Lake,4 S. Gentry,2,3 D. Segev,2 A. Israni,1 J. Snyder.1

    1SRTR, Minneapolis Medical Research Foundation, Minneapolis, MN; 2Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; 3Mathematics, US Naval Academy, Baltimore, MD; 4Medicine and Surgery, University of Minnesota Medical School, Minneapolis, MN; 5School of Medicine, Stanford University, Stanford, CA.

    We aimed to compare liver transplant simulation projections to observed data before and after a major policy update. The current liver simulated allocation model (LSAM…
  • 2015 American Transplant Congress

    U.S. National Experience of Liver Transplantation Using Allografts from Octogenarian Donors

    C. Bhati, I. Tzvetanov, R. Garcia-Roca, J. Oberholzer, E. Benedetti, H. Jeon.

    Surgery, Division of Transplantation, University of Illinois at Chicago, Chicago, IL.

    IntroductionA continuous worsening of donor organ shortage has led to expand organ acceptance criteria. It is still theoretically possible to utilize hepatic allografts from donors…
  • 2015 American Transplant Congress

    Mechanisms Underlying Treg Dysfunction in DAIH- Role for PD-L1?

    A. Arterbery,1 M. Martinez,2 S. Lobritto,2 Y. Avitzur,3 K. Raddassi,1 M. Kleinewietfeld,4 U. Ekong.1

    1Yale, NH; 2Columbia, NY; 3HSC, Toronto, Canada; 4Dresden University of Technology, Dresden, Germany.

    Background: we have previously shown that ex vivo Tregs from patients with DAIH demonstrate differentiation plasticity towards TH17. To understand the mechanisms underlying this we…
  • 2015 American Transplant Congress

    Association Between Polymorphisms of PPM1E Gene and Tumor Size of Hepatocellular Carcinoma Patients

    M.-S. Park,1 S.-K. Kim.2

    1Surgery, Kyung Hee University Hospital, Seoul, Korea; 2Pharmacology, Kyung Hee University, Seoul, Korea.

    The protein phosphatase, Mg2+/Mn2+ dependent, 1E (PPM1E) inactivates multiple substrates including 5'-AMP activate protein kinases (AMPK) which inhibits the growth and survival of cancer cells.…
  • 2015 American Transplant Congress

    Tobacco Use Is a Significant Risk Factor for Post-Transplant Biliary Complications

    D. Dulaney, M. Dokus, M. Orloff, R. Kashyap.

    Surgery, University of Rochester Medical Center, Rochester, NY.

    Purpose: Biliary complications following liver transplantation are a significant source of morbidity, potentially leading to graft failure necessitating retransplantation. Smoking precipitates both microvascular and macrovascular…
  • 2015 American Transplant Congress

    Post-Liver Transplant Metabolic Syndrome Increases the Risk of Recurrent Fibrosis in Patients With Hepatitis C

    R. Sharma, M. Laurito, R. Brown, Jr., E. Verna.

    Department of Medicine, Columbia University, New York, NY.

    Introduction: Post-liver transplant (LT) metabolic syndrome (MS) is common and may impact fibrosis progression in LT recipients with hepatitis C virus (HCV). Methods: All adults…
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