Articles tagged "Liver transplantation"

2015 American Transplant Congress
Ischemia Reperfusion Injury in Orthotopic Liver Transplantation Primes the Adaptive Immune Response and Generation of Proinflammatory Cytokines
A. Zarrinpar,¹ P. Rao,² C. Lassman,² V. Agopian,¹ F. Kaldas,¹ D. Farmer,¹ R. Busuttil,¹ Y. Zhai,¹ J. Kupiec-Weglinski,¹ E. Reed.²
¹Surgery, University of California, Los Angeles, Los Angeles, CA; ²Pathology and Lab Medicine, University of California, Los Angeles, Los Angeles, CA.
Background: Transplanted organs are exquisitely susceptible to effects of ischemia/reperfusion injury (IRI), an immune-mediated process that occurs during transplantation and beyond. Recipient and graft outcomes,…
2015 American Transplant Congress
Long-Term Survival Outcomes of Liver Transplantation for Klatskin Tumour: A Comparative Study With Radical Resection Surgery
A. Hu, X. Zhu, X. He.
Department of general Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Background and aim: Besides radical resection (RR), Liver transplantation (LT) is another suggested surgical modality for hilar cholangiocarcinoma (Klatskin tumour, KT) especially for patients whose…
2015 American Transplant Congress
Estimation of Glomerular Filtration Rate With Serum Cystatin C Accurately Discriminates Renal Dysfunction in Liver Transplant Candidates With End-Stage Liver Disease
S. Gonzalez,¹ J. Trotter,¹ H. Szerlip,² M. Levy,³ A. Chandrakantan,⁴ A. Yango,⁴ A. Rajagopal,⁴ Y. Barri,⁴ K. Rice,⁴ M. Saim,² L. Melton,⁴ M. Emmett,² G. Klintmalm,³ B. Fischbach.⁴
¹Hepatology, Baylor Simmons Transplant Institute, Fort Worth, TX; ²Nephrology, Baylor University Medical Center, Dallas, TX; ³Transplant Surgery, Baylor Simmons Transplant Institute, Fort Worth, TX; ⁴Nephrology, Baylor Simmons Transplant Institute, Fort Worth, TX.
Background: Renal insufficiency is common in end-stage liver disease (ESLD) and is linked to survival in patients awaiting liver transplantation. Serum creatinine correlates poorly with…
2015 American Transplant Congress
Safety and Efficacy of All Oral DAA Therapy for Genotype 1 HCV Post-Liver Transplant: Interval Results from the HCV-TARGET Multicenter Prospective Observational Study
J. O'Leary,¹ R. Brown,² K. Reddy,³ A. Kuo,⁴ G. Morelli,⁵ R. Stravitz,⁶ G. Everson,⁷ C. Durand,⁸ H. Vargas,⁹ P. Kwo,¹⁰ C. Frenette,¹¹ J. Peter,¹² M. Vainorius,¹² L. Akushevich,¹² D. Nelson,⁵ M. Fried,¹² N. Terrault.¹³
¹Baylor University Medical Center, TX; ²Columbia University, NY; ³University of Pennsylvania, PA; ⁴UCSD, CA; ⁵University of Florida, Gainesville, Gainesville, FL; ⁶Virginia Commonwealth University, VA; ⁷University of Colorado, CO; ⁸Johns Hopkins, MD; ⁹Mayo Clinic, AZ; ¹⁰Indiana University, IL; ¹¹Scipps Clinic, CA; ¹²University of North Carolina, NC; ¹³UCSF, CA.
The safety and efficacy of direct-acting antivirals (DAA) for HCV post-LT remain unknown. METHODS: We describe the safety and efficacy of all oral DAA-therapy for…
2015 American Transplant Congress
Combination of Non-HLA and HLA-DSA Antibodies Identifies Liver Transplants Recipients With Highest Risk for Fibrosis Progression and Mortality
J. O'Leary,¹ J. Cai,² H. Heidecke,³ L. Jennings,¹ A. Philippe,⁴ V. Harbour,¹ R. Catar,⁴ P. Terasaki,² G. Klintmalm,¹ D. Dragun.⁴
¹Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX; ²Terasaki Foundation Laboratory, Los Angeles, CA; ³Celltrend, Berlin, Germany; ⁴Nephrology & Intensive Care Medicine, Charite Berlin, Berlin, Germany.
Recent data has shown an increased risk of fibrosis progression in HCV viremic liver transplant (LT) recipients with HLA DSA in serum. However, the role…
2015 American Transplant Congress
Liver Allograft Utilization Within the United States: 2003-2013
J. Renz,¹ G. Diaz,¹ L. Ratner,² H. Yersiz,³ M. Millis,¹ J. Matthews.¹
¹Department of Surgery, University of Chicago, Chicago, IL; ²Department of Anesthesia/Critical Care, University of Chicago, Chicago, IL; ³Department of Surgery, Columbia University, New York, NY; ⁴Department of Surgery, University of California Los Angeles, Los Angeles, CA.
Objectives: 1) Evaluate liver allograft availability, utilization, and failure probability utilizing the liver donor risk index(LDRI) 2) Correlate allograft utilization with waitlist mortality and incidence…
2015 American Transplant Congress
Sofosbuvir Therapy in Early and Late Post Liver Transplant Setting: A Single Center Experience
X. Zervos,¹ D. Beltran,² B. Ismail,¹ M. Watson,¹ D. Sears,¹ A. Tzakis.¹
¹Liver Transplant, Cleveland Clinic Florida, Weston, FL; ²Pharmacy, Cleveland Clinic Florida, Weston, FL.
Background: Hepatitis C (HCV) treatment has entered a new phase of excitement with new oral therapies. Here we describe our experience of sofosbuvir (SOF) based…
2015 American Transplant Congress
Incidence and Risk Factors for Infectious Complications in Liver Transplant Patients Converted to Everolimus
A. Islam,¹ J. DeVos,² L. Teeter,³ E. Graviss,³ S. Gordon-Burroughs,¹ A. Saharia,¹ C. Mobley,¹ A. Gaber,¹ R. Ghobrial.¹
¹Department of Surgery, Houston Methodist Hospital, Houston, TX; ²Department of Pharmacy, Houston Methodist Hospital, Houston, TX; ³Department of Pathology & Genomic Medicine, Houston Methodist Hospital, Houston, TX.
AIM:Immunosuppression with an mTOR inhibitor plus calcineurin inhibitor (CNI) minimization is increasingly used in liver transplantation to protect against the nephrotoxic and neurotoxic side effects…
2015 American Transplant Congress
Renal Dysfunction After Liver Transplantation in Recipients With Pre-Transplant Normal Renal Function
S. Lee,² J. Lee,¹ M. Kim,¹ B. Kim,³ D. Joo,¹ G. Choi,¹ J. Choi,¹ S. Kim.¹
¹Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea; ²Surgery, Ajou University School of Medicine, Suwon, Republic of Korea; ³Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Background. Renal dysfunction is a severe complication associated with adverse outcomes after liver transplantation (LT). The aim of our study is to identify the incidence…
2015 American Transplant Congress
HLA Matching Affects Patient Survival, Graft Survival, and Incidence of Rejection Episodes in Largest Analysis to Date
J. Weiner, Z. Cui, S. Mohan, E. Verna, A. Griesemer, J. Emond.
Columbia Center for Liver Disease and Transplantation, New York Presbyterian-Columbia University Medical Center, New York, NY.
Introduction: Though human leukocyte antigen (HLA) matching between donor and recipient affects both graft and patient survival after kidney and heart transplantation, prior analysis has…