Articles tagged "Liver transplantation"

2016 American Transplant Congress
Caval Replacement versus Piggyback Liver Transplantation: The Toronto Experience.
A. Barbas, M. Dib, N. Goldaracena, M. Marquez, G. Sapisochin, D. Al-Adra, S. McCluskey, I. McGilvray.
General Surgery, Multi-Organ Transplant, University of Toronto, Toronto, ON, Canada.
Background:Caval replacement (CR) and piggyback (PB) techniques for deceased donor liver transplantation (DDLT) each have inherent advantages and disadvantages with no consensus on the optimal…
2016 American Transplant Congress
Sublingual Tacrolimus in Liver Transplantation: A Valid Option?
M. Moreno Gonzales,¹ L. Myhre,² T. Taner.¹
¹Division of Transplantation Surgery, Mayo Clinic, Rochester, MN; ²Department of Pharmacy, Mayo Clinic, Rochester, MN.
Introduction. Oral tacrolimus (Tac) is currently the pilar of maintenance immunosuppression following solid organ transplantation and the most common route of drug delivery. Recent studies…
2016 American Transplant Congress
The Impact of Thromboelastography on Resuscitation in Pediatric Liver Transplantation.
K. Gonzalez,¹ K. Curiel,¹ B. Dalton,¹ V. Fioravanti,¹ W. Andrews,¹ B. Wicklund,² R. Hendrickson.¹
¹Department of Pediatric Surgery, Children's Mercy Hospital, Kansas City, MO; ²Department of Hematology, Children's Mercy Hospital, Kansas City, MO.
Introduction: Thromboelastography (TEG) directs effective resuscitation in adult surgical and trauma patients. There is little data on TEG use in pediatrics. In 2011 we began…
2016 American Transplant Congress
Sudden Increase in Allocation Score for Pediatric Liver Transplant Candidates Predicts Waitlist Mortality.
X. Luo, D. Mogul, A. Massie, D. Segev.
JHU, Baltimore.
Allocation for deceased donor livers is prioritized in the U.S. by waitlist mortality, as predicted by PELD for children<12 years, and MELD for individuals>12 years.…
2016 American Transplant Congress
AT1R Antibodies at 1-Year Negatively Impact 5-Year Native Renal Function in Liver Transplant Recipients.
J. O'Leary,¹ A. Philippe,² H. Heidecke,² R. Freeman,¹ L. Jennings,¹ R. Catar,² G. Klintmalm,¹ D. Dragun.²
¹Baylor Simmons Transplant Insttute, Baylor University Medical Center, Dallas, TX; ²Internal Medicine, Charite, Berlin, Germany.
Angiotensin II Type-1 Receptor (AT1R) antibodies have been associated with pulmonary hypertension, renal allograft loss, and fibrosis progression in liver allograft recipients especially if combined…
2016 American Transplant Congress
IL-2 Therapy Restores the Impaired Function of Regulatory T Cells Induced by Calcineurin Inhibitors in Liver Transplantation.
G. Whitehouse, E. Gray, S. Mastoridis, E. Kodela, A. Sanchez-Fueyo, M. Martinez-Llordella.
Liver Science Department, King's College London, London, United Kingdom.
CD4+CD25+FOXP3+ regulatory T cells (Tregs) have an essential role in immune regulation and constitute a key target for cellular immunotherapies in transplantation. IL-2 is critical…
2016 American Transplant Congress
Evaluation of the Long-Term Outcomes with Everolimus After Calcineurin Inhibitor Withdrawal: 36M Results of the H2304 and PROTECT Extension Studies.
L. Fischer,^1,2 J. Fung,¹ H. Metselaar,¹ G. Kaiser,^1,2 P. Schemmer,² P. Neuhaus,² G. Dong,³ P. Lopez,⁴ P. Bernhardt,⁴ H. Schlitt.²
¹H2304 study group, Hamburg, Germany; ²PROTECT study group, Hamburg, Germany; ³Novartis Pharmaceuticals Corporation, East Hanover, NJ; ⁴Novartis Pharma AG, Basel, Switzerland.
Background: The H2304 and PROTECT studies demonstrated reduced nephrotoxicity with everolimus (EVR)-based calcineurin inhibitor (CNI; cyclosporine: CsA, tacrolimus: TAC)-free regimens at Month (M) 12. Here,…
2016 American Transplant Congress
Metabolomic Profiles of Hepatocellular Carcinoma and Cirrhotic Patients Before and After Transplantation.
C. Desai,¹ R. Varghese,² S. Robertazzi,¹ C. Di Poto,² A. Ferrarini,² C. Tu,² R. Girlanda,¹ K. Khan,¹ T. Fishbein,¹ H. Ressom.²
¹Medstar Georgetown Transplant institute, Washington DC; ²Department of Oncology, Lombardi Comprehensive Cancer Center, Washington DC.
Metabolomics offers the opportunity to characterize complex diseases like hepatocellular carcinoma (HCC) through a systematic evaluation of thousands of metabolites in human liver tissues and…
2016 American Transplant Congress
Assessment of Transplant Health Literacy of Liver Transplant Candidates and Their Caregivers.
Y. Bababekov,¹ Z. Fong,^1,2 J. Adler,¹ H. Yeh,¹ D. Chang,^1,2 J. Pomposelli.³
¹Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA; ²Codman Center for Clinical Effectivness in Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA; ³Transplantation, Lahey Hospital and Medical Center, Burlington, MA.
Purpose: All transplant programs provide education sessions and instructional material to their patients to improve health literacy. However, their efficacy is unknown. We piloted a…
2016 American Transplant Congress
Trends in Liver Transplant Rates and Waitlist Survival.
M. Bowring, A. Massie, X. Luo, L. Kucirka, E. Chow, A. Cameron, D. Segev.
JHU, Baltimore.
Long term changes in access to deceased-donor liver transplantation(DDLT) due to persistent growth of the waitlist, stagnant organ availability, and intermittent allocation policy changes have…