Articles tagged "Liver transplantation"

2017 American Transplant Congress
HCV Eradication with DAA Therapy Should Be Attempted Prior to Liver Transplantation and Does Not Impact HCC Recurrence.
J. Emamaullee, M. Bral, G. Meeberg, A. Montano-Loza, V. Bain, D. Bigam, N. Kneteman, A. Shapiro.
University of Alberta, Edmonton, AB, Canada
Background: Recent advances in the direct-acting antiviral (DAA) treatment of HCV have lead to high rates of HCV eradication, even in patients with decompensated cirrhosis.…
2017 American Transplant Congress
Normothermic Regional Perfusion of Donors Following Circulatory Death Improves Outcomes in Liver Transplantation.
E. Mowlem,¹ L. Randle,² C. Fear,¹ K. Crick,¹ S. Messer,⁴ S. Large,⁴ A. Butler,³ C. Watson.³
¹Cambridge Transplant Unit, Addenbrookes Hospital, Cambridge, United Kingdom; ²OrganOx Ltd, Oxford, United Kingdom; ³Dept of Surgery, University of Cambridge, Cambridge, United Kingdom; ⁴Papworth Hospital, Cambridge, United Kingdom
Introduction: Donation after Circulatory Death (DCD) provides 23% of UK livers for transplantation, but such transplants are associated with more primary graft function and early…
2017 American Transplant Congress
Clinical Evaluation of the Safety and Preliminary Efficacy of Continuous Infusion of Treprostinil to Prevent Ischemia and Reperfusion Injury in Adult Orthotopic Liver Transplant Recipients.
O. Almazroo,¹ M. Miah,¹ V. Pillai,¹ A. Humar,² A. Tevar,² C. Hughes,² A. AlKhafaji,³ A. Demetris,⁴ S. Dermont,² S. Fedorek,² H. Johnson,¹ R. Lopez,² R. Planinsic,² B. Sengupta,² I. Sethu,² M. Sturdevant,² S. Ziobert,¹ R. Venkataramanan.^1,2,4
¹Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA; ²Thomas Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; ³Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA; ⁴Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA
Introduction:Liver transplantation is currently the only therapeutic option for patients with end stage liver diseases. Liver allografts undergo cold ischemic injury and warm reperfusion injury…
2017 American Transplant Congress
Community Health, Center Proximity, and Liver Transplant Waitlist Mortality.
R. Lynch,¹ K. Ross,¹ D. Goldberg,² R. Patzer.¹
¹Surgery, Emory University, Atlanta, GA; ²Medicine, University of Pennsylvania, Philadelphia, PA
Background: While regional organ availability is frequently discussed in allocation policy, the impact of community-level factors and access to a transplant center on waitlist mortality…
2017 American Transplant Congress
The Combined Effects of Induction Regimens and Antiviral Prophylaxis on the Risk of CMV Infection in Different Serostatus Subgroups After Liver Transplantation.
C. Low,² S. Hosseini-Moghaddam,^1,2 C. Rotstein,² E. Renner,² A. Humar,² D. Kumar,² S. Husain.²
¹Medicine, Western University, London Health Sciences Centre, London, Canada; ²University Health Network, Toronto, Canada
Introduction: Simultaneous effects of anti-CMV prophylaxis and induction regimens on cytomegalovirus (CMV) infection after liver transplantation (LTRs) have not been studied. We determined the magnitude…
2017 American Transplant Congress
Predicting Recurrence Prior to Transplant: The Response of HCC to Chemoembolization.
T. Sandow,¹ H. Bohorquez,² D. Kirsch,¹ P. Thevenot,³ K. Nunez,³ A. Albar,¹ D. DeVun,¹ J. Gimenez,¹ G. Galliano,⁴ A. Cohen,² G. Loss,² D. Kay,¹ P. Gulotta.¹
¹Radiology, Ochsner Clinic Foundation, New Orleans, LA; ²Transplant Surgery, Ochsner Clinic Foundation, New Orleans, LA; ³Institute of Translational Research, Ochsner Clinic Foundation, New Orleans, LA; ⁴Pathology, Ochsner Clinic Foundation, New Orleans, LA
Purpose:This study assesses imaging response characteristics of patients with hepatocellular carcinoma (HCC) to chemoembolization (TACE) as a bridge to transplant and the risk of post-transplant…
2017 American Transplant Congress
Effect of Epigenetic Modifications in Ischemia-Reperfusion-Injury Post Liver Transplantation: An Integrative Approach.
D. Bagchi, S. Bontha, M. Dozmorov, A. Fernandez, V. Mas, D. Maluf.
Surgery, UVA, Charlottesville; VCU, Richmond
Background Free radicals generated during ischemia reperfusion injury (IRI) might result in epigenetic modifications and gene expression (GE) changes affecting graft outcomes. Integrative analyses of…
2017 American Transplant Congress
Optimizing Survival Outcomes for Advanced Age Patients Undergoing Liver Transplant.
J. Balogh, K. Lunsford, D. Nguyen, E. Gravis, A. Saharia, C. Mobley, S. Gordon Burroughs, O. Cercio, D. Victor, H. Monsour, A. Gaber, R. Ghobrial.
Houston Methodist Hospital, Houston, TX
ObjectivesAge at liver transplant (LT) is progressively increasing and is a known risk factor for mortality. We sought to evaluate preTx predictors for mortality among…
2017 American Transplant Congress
Safety of Liver Donation from Living Donors with Sickle Cell Trait.
H. Elsiesy,^1,2 M. Sturdevant,¹ W. Al-Hamoudi,¹ H. Elbeshbeshy,¹ M. Al Sebayel,¹ A. Jaafari,¹ F. Abaalkhail.^1,2
¹Liver Trasplantation, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia; ²Medicine, Alfaisal University, Riyadh, Saudi Arabia; ³Gastroenterology, King Saud University, Riyadh, Saudi Arabia
Background:Living donor liver transplant (LDLT) is an important source of organs particularly with the cadaveric organ shortage. It is the main source of liver transplant…
2017 American Transplant Congress
Acute Renal Replacement Therapy in Pediatric Liver Transplantation: A Predictor of Increased Risk.
M. Wong,¹ R. Venick,² V. Agopian,¹ S. Ebaid,¹ S. McDiarmid,² A. Zarrinpar,¹ D. Farmer,¹ R. Busuttil,¹ F. Kaldas.¹
¹Surgery, UCLA, Los Angeles, CA; ²Pediatric Gastroenterology, UCLA, Los Angeles, CA
BackgroundAmong pediatric patients (≤18 yrs) awaiting liver transplantation (LT), limited data exist on the prognostic significance of acute (<90d) renal replacement therapy (RRT) prior to…