ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Predicting Recurrence Prior to Transplant: The Response of HCC to Chemoembolization.

T. Sandow,1 H. Bohorquez,2 D. Kirsch,1 P. Thevenot,3 K. Nunez,3 A. Albar,1 D. DeVun,1 J. Gimenez,1 G. Galliano,4 A. Cohen,2 G. Loss,2 D. Kay,1 P. Gulotta.1

1Radiology, Ochsner Clinic Foundation, New Orleans, LA
2Transplant Surgery, Ochsner Clinic Foundation, New Orleans, LA
3Institute of Translational Research, Ochsner Clinic Foundation, New Orleans, LA
4Pathology, Ochsner Clinic Foundation, New Orleans, LA

Meeting: 2017 American Transplant Congress

Abstract number: A79

Keywords: Hepatocellular carcinoma, Liver transplantation, Prediction models, Recurrence

Session Information

Date: Saturday, April 29, 2017

Session Name: Poster Session A: Clinical Science: Liver - Hepatocellular Carcinoma and Cholangiocarcinoma Malignancies

Session Time: 5:30pm-7:30pm

 Presentation Time: 5:30pm-7:30pm

Location: Hall D1

Related Abstracts
  • Pre-TACE Immune Status Correlates with Treatment Response and Tumor Biology in HCC as a Bridge to Transplant.
  • Clinical Usefulness of mRECIST Response to Chemoembolization for Recurrence Prediction of Hepatocellular Carcinoma in Living Donor Liver Transplantation.

Purpose:

This study assesses imaging response characteristics of patients with hepatocellular carcinoma (HCC) to chemoembolization (TACE) as a bridge to transplant and the risk of post-transplant recurrence.

Materials:

Retrospective analysis was performed on all HCC patients who were treated with TACE (100-300[micro] LC Beads™ mixed with doxorubicin) from 2011 to 2016 and later transplanted. Treatment response was based on modified RECIST imaging criteria. Multiple treatment cycles were performed in cases of partial response (PR), stable disease (SD), and disease progression (DP) at follow-up. Patients with complete response (CR) were monitored with routine imaging. The most immediate post-treatment imaging response prior to transplantation was compared with tumor biology and recurrence.

Results:

Eighty-two patients were followed after transplant (mean time of follow-up, 659 days). Recurrence occurred in 7 (8.5%) patients (mean time from transplant, 635 days). Poor response to TACE (SD/DP) was present in 86% of patients with recurrence and accounted for 35% of all patients with SD/DP (p=0.0002). Lesion size (4.5 cm with vs 3.5 cm without, p=0.09), lymphovascular invasion (57% with vs 16% without, p=0.02), and satellite nodules (57% with vs 20% without, p=0.05) demonstrated significance for recurrence. Post-transplant RETREAT (Risk Estimation of Tumor Recurrence After Transplant) score showed recurrence in 13% of score 4 and 33% of score >5 (p=0.06).

Multivariate Analysis with recurrence as the outcome model
Variable OR p-value
Lesion size 1.76 0.08
Poor response to TACE (SD/DP) prior to transplant 56.5 0.0045
Lymphovascular invasion at explant 1.64 0.69
Satellite nodules at explant 3.15 0.36

Conclusions:

Poor TACE treatment response demonstrates similar efficacy in predicting post-transplant recurrence at similar follow-up intervals compared with RETREAT. Given its pre-transplant predictive value, it allows for improved selection criterion and better strategy in the treatment of HCC.

CITATION INFORMATION: Sandow T, Bohorquez H, Kirsch D, Thevenot P, Nunez K, Albar A, DeVun D, Gimenez J, Galliano G, Cohen A, Loss G, Kay D, Gulotta P. Predicting Recurrence Prior to Transplant: The Response of HCC to Chemoembolization. Am J Transplant. 2017;17 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Sandow T, Bohorquez H, Kirsch D, Thevenot P, Nunez K, Albar A, DeVun D, Gimenez J, Galliano G, Cohen A, Loss G, Kay D, Gulotta P. Predicting Recurrence Prior to Transplant: The Response of HCC to Chemoembolization. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/predicting-recurrence-prior-to-transplant-the-response-of-hcc-to-chemoembolization/. Accessed January 19, 2021.

« Back to 2017 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.