Articles tagged "Liver transplantation"

2017 American Transplant Congress
Early Acute Cellular Rejection(eACR) as a Marker of Immunologic Competency Following Liver Transplantation(LT).
V. Kirchner, A. Bandgdiwala, D. Vock, M. Hassan, R. Kandaswamy, J. Lake, N. Lim, A. Mahgoub, E. Minja, A. Pugalenthi, B. Sengupta, O. Serrano, J. Thompson, W. Payne, T. Pruett, S. Chinnakotla.
University of Minnesota, Minneapolis, MN
Background:Historically eACR did not adversely impact patient survival(PS). Since infection(Ifx) is major cause of death(COD) among LT recipients, we hypothesized that eACR is marker of…
2017 American Transplant Congress
Prominence of Graft-Infiltrating PD-L1^hi Cross-Dressed Dendritic Cells in Mouse Liver Transplant Tolerance.
Y. Ono, A. Perez Gutierrez, S. Yokota, O. Yoshida, T. Nakao, G. Camirand, D. Geller, A. Thomson.
Surgery, University of Pittsburgh, Pittsburgh, PA
Background: The mechanism underlying spontaneous liver allograft tolerance remains unclear. Given recent reports on the key role of recipient mouse dendritic cells (DCs) in host…
2017 American Transplant Congress
Glucocorticoid Receptor – Relaxin Signaling in Liver Transplant Ischemia-Reperfusion Injury (IRI): From Bench-to-Bedside.
S. Kageyama,¹ K. Nakamura,¹ R. Sossa,² E. Reed,² N. Datta,¹ A. Zarrinpar,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹The Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles, CA; ²Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA
Background: Glucocorticoid receptor (GR) serves as a receptor for relaxin (RLX), a pregnancy hormone, with novel vasoactive and tissue remodeling properties. A phase III clinical…
2017 American Transplant Congress
Predicting Recurrence Prior to Transplant: The Response of HCC to Chemoembolization.
T. Sandow,¹ H. Bohorquez,² D. Kirsch,¹ P. Thevenot,³ K. Nunez,³ A. Albar,¹ D. DeVun,¹ J. Gimenez,¹ G. Galliano,⁴ A. Cohen,² G. Loss,² D. Kay,¹ P. Gulotta.¹
¹Radiology, Ochsner Clinic Foundation, New Orleans, LA; ²Transplant Surgery, Ochsner Clinic Foundation, New Orleans, LA; ³Institute of Translational Research, Ochsner Clinic Foundation, New Orleans, LA; ⁴Pathology, Ochsner Clinic Foundation, New Orleans, LA
Purpose:This study assesses imaging response characteristics of patients with hepatocellular carcinoma (HCC) to chemoembolization (TACE) as a bridge to transplant and the risk of post-transplant…
2017 American Transplant Congress
Effect of Epigenetic Modifications in Ischemia-Reperfusion-Injury Post Liver Transplantation: An Integrative Approach.
D. Bagchi, S. Bontha, M. Dozmorov, A. Fernandez, V. Mas, D. Maluf.
Surgery, UVA, Charlottesville; VCU, Richmond
Background Free radicals generated during ischemia reperfusion injury (IRI) might result in epigenetic modifications and gene expression (GE) changes affecting graft outcomes. Integrative analyses of…
2017 American Transplant Congress
Optimizing Survival Outcomes for Advanced Age Patients Undergoing Liver Transplant.
J. Balogh, K. Lunsford, D. Nguyen, E. Gravis, A. Saharia, C. Mobley, S. Gordon Burroughs, O. Cercio, D. Victor, H. Monsour, A. Gaber, R. Ghobrial.
Houston Methodist Hospital, Houston, TX
ObjectivesAge at liver transplant (LT) is progressively increasing and is a known risk factor for mortality. We sought to evaluate preTx predictors for mortality among…
2017 American Transplant Congress
Incidence and Outcomes of Re-Explorations in Living Donor Liver Transplantation.
V. Varma, S. Sable, S. Kapoor, A. Chauhan, V. Kumaran.
Hepato-Biliary-Pancreatic Surgery and Liver Transplantation, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, Maharashtra, India
Introduction: Re-exploration in Living Donor Liver Transplantation(LDLT) is required in patients for various causes, bleeding being the commonest cause. The outcome of these patients is…
2017 American Transplant Congress
Long-Term Pediatric Live-Donor Liver Transplantation Survivors: Patient and Allograft Outcomes.
N. Celik,¹ A. Ganoza,¹ G. Bond,¹ K. Soltys,¹ R. Sindhi,¹ P. McKiernan,³ A. Humar,² G. Mazariegos.¹
¹Hillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA; ²Thomas E. Starzl Transplantation Institute, Pittsburgh, PA; ³Division of Pediatric Gastroenterology, Pittsburgh, PA
Aim: To determine the patient and allograft outcomes at 5 years after pediatric live-donor liver transplantation (LDLT).Methods: Children with a minimum of 5-year survival post-transplantation…
2017 American Transplant Congress
Sequential Liver-Kidney Transplantation Is Equivalent to Simultaneous Liver–Kidney Transplantation in Candidates Requiring Dialysis Pre-Transplant.
M. Mulvihill, B. Yerokun, R. Davis, K. Anderson, M. Hartwig, A. Barbas.
Surgery, Duke University Medical Center, Durham, NC
Introduction: Liver transplant is the optimal therapy for patients with end-stage liver disease (ESLD). Appropriately-selected candidates with renal impairment benefit from transplantation of liver and…
2017 American Transplant Congress
Experimental Study of Hepatocyte Proliferation Regulated by miR26a.
J. Zhou, X. Yuan, W. Ju, X. Jiao, D. Wang, X. Zhu, X. He.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Objective To investigate mechanisms of regulation on hepatocyte proliferation by miRNAs. Methods Normal hepatocyte in ivtro was transfected with vectors harboring Ad5/anti-miR26a or Ad5/miR26a, and…