Articles tagged "Liver transplantation"

2017 American Transplant Congress
Early Acute Cellular Rejection(eACR) as a Marker of Immunologic Competency Following Liver Transplantation(LT).
V. Kirchner, A. Bandgdiwala, D. Vock, M. Hassan, R. Kandaswamy, J. Lake, N. Lim, A. Mahgoub, E. Minja, A. Pugalenthi, B. Sengupta, O. Serrano, J. Thompson, W. Payne, T. Pruett, S. Chinnakotla.
University of Minnesota, Minneapolis, MN
Background:Historically eACR did not adversely impact patient survival(PS). Since infection(Ifx) is major cause of death(COD) among LT recipients, we hypothesized that eACR is marker of…
2017 American Transplant Congress
Prominence of Graft-Infiltrating PD-L1^hi Cross-Dressed Dendritic Cells in Mouse Liver Transplant Tolerance.
Y. Ono, A. Perez Gutierrez, S. Yokota, O. Yoshida, T. Nakao, G. Camirand, D. Geller, A. Thomson.
Surgery, University of Pittsburgh, Pittsburgh, PA
Background: The mechanism underlying spontaneous liver allograft tolerance remains unclear. Given recent reports on the key role of recipient mouse dendritic cells (DCs) in host…
2017 American Transplant Congress
Glucocorticoid Receptor – Relaxin Signaling in Liver Transplant Ischemia-Reperfusion Injury (IRI): From Bench-to-Bedside.
S. Kageyama,¹ K. Nakamura,¹ R. Sossa,² E. Reed,² N. Datta,¹ A. Zarrinpar,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹The Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles, CA; ²Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA
Background: Glucocorticoid receptor (GR) serves as a receptor for relaxin (RLX), a pregnancy hormone, with novel vasoactive and tissue remodeling properties. A phase III clinical…
2017 American Transplant Congress
Predicting Recurrence Prior to Transplant: The Response of HCC to Chemoembolization.
T. Sandow,¹ H. Bohorquez,² D. Kirsch,¹ P. Thevenot,³ K. Nunez,³ A. Albar,¹ D. DeVun,¹ J. Gimenez,¹ G. Galliano,⁴ A. Cohen,² G. Loss,² D. Kay,¹ P. Gulotta.¹
¹Radiology, Ochsner Clinic Foundation, New Orleans, LA; ²Transplant Surgery, Ochsner Clinic Foundation, New Orleans, LA; ³Institute of Translational Research, Ochsner Clinic Foundation, New Orleans, LA; ⁴Pathology, Ochsner Clinic Foundation, New Orleans, LA
Purpose:This study assesses imaging response characteristics of patients with hepatocellular carcinoma (HCC) to chemoembolization (TACE) as a bridge to transplant and the risk of post-transplant…
2017 American Transplant Congress
Effect of Epigenetic Modifications in Ischemia-Reperfusion-Injury Post Liver Transplantation: An Integrative Approach.
D. Bagchi, S. Bontha, M. Dozmorov, A. Fernandez, V. Mas, D. Maluf.
Surgery, UVA, Charlottesville; VCU, Richmond
Background Free radicals generated during ischemia reperfusion injury (IRI) might result in epigenetic modifications and gene expression (GE) changes affecting graft outcomes. Integrative analyses of…
2017 American Transplant Congress
Optimizing Survival Outcomes for Advanced Age Patients Undergoing Liver Transplant.
J. Balogh, K. Lunsford, D. Nguyen, E. Gravis, A. Saharia, C. Mobley, S. Gordon Burroughs, O. Cercio, D. Victor, H. Monsour, A. Gaber, R. Ghobrial.
Houston Methodist Hospital, Houston, TX
ObjectivesAge at liver transplant (LT) is progressively increasing and is a known risk factor for mortality. We sought to evaluate preTx predictors for mortality among…
2017 American Transplant Congress
Safety of Liver Donation from Living Donors with Sickle Cell Trait.
H. Elsiesy,^1,2 M. Sturdevant,¹ W. Al-Hamoudi,¹ H. Elbeshbeshy,¹ M. Al Sebayel,¹ A. Jaafari,¹ F. Abaalkhail.^1,2
¹Liver Trasplantation, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia; ²Medicine, Alfaisal University, Riyadh, Saudi Arabia; ³Gastroenterology, King Saud University, Riyadh, Saudi Arabia
Background:Living donor liver transplant (LDLT) is an important source of organs particularly with the cadaveric organ shortage. It is the main source of liver transplant…
2017 American Transplant Congress
Acute Renal Replacement Therapy in Pediatric Liver Transplantation: A Predictor of Increased Risk.
M. Wong,¹ R. Venick,² V. Agopian,¹ S. Ebaid,¹ S. McDiarmid,² A. Zarrinpar,¹ D. Farmer,¹ R. Busuttil,¹ F. Kaldas.¹
¹Surgery, UCLA, Los Angeles, CA; ²Pediatric Gastroenterology, UCLA, Los Angeles, CA
BackgroundAmong pediatric patients (≤18 yrs) awaiting liver transplantation (LT), limited data exist on the prognostic significance of acute (<90d) renal replacement therapy (RRT) prior to…
2017 American Transplant Congress
The Beneficial Effects of mTOR Inhibitors on Liver Resident Natural Killer Cells.
J. Saparbay, Y. Tanaka, T. Yano, H. Ohdan.
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
(Background) The immunosuppressive regimen currently used after organ transplantation reduces adaptive components. Therefore, the innate immune cells play pivotal roles in immune surveillance and defense…
2017 American Transplant Congress
Liver Transplantation Tolerance Using Outbred Mice.
M. Morita,¹ C. Miller,² J. Fung,³ L. Lu,^1,2 S. Qian.^1,2
¹Immunology, Cleveland Clinic, Cleveland, OH; ²General Surgery, Cleveland Clinic, Cleveland, OH; ³University of Michigan, Chicago, MI
Success of organ transplantation currently depends on life-time immunosuppression, resulting in severe side effects. Induction of donor specific tolerance is ideal, which actually spontaneously occurs…