2022 American Transplant Congress
Evolution of the Need for Transplant Evaluations for Liver Failure Decompensation After TIPS
*Purpose: Portal hypertension is described as an increased pressure gradient between the portal and systemic circulation which can result in severe complications. Transjugular Intrahepatic Portosystemic…2022 American Transplant Congress
Association Between CT Measurements of Body Composition Before Liver Transplantation and Post-Transplantation Outcomes
1Johns Hopkins University, Baltimore, MD, 2NIH Clinical Center, Bethesda, MD
*Purpose: Various methods exist for measuring body composition using computed tomography (CT) scans; however, it is unclear which components best predict post-liver transplantation (LT) outcomes.…2022 American Transplant Congress
The Role Of Ferroptosis In Modulating Ischemia Reperfusion Injury(IRI) Gene Expression In Marginal Donor Livers(MDLS) Using The Novel Protect Normothermic Perfusion Pump
*Purpose: Severe IRI can impair liver allograft when using MDLs and accounts for high discard rates. We tested iron chelators to reduce ferroptosis and IRI.…2022 American Transplant Congress
Normothermic Machine Perfusion in Liver Transplantation – Seven Year Experience at a Single North American Centre
*Purpose: Machine perfusion for preservation of liver grafts before transplantation has risen in prominence over the past decade. Normothermic machine perfusion (NMP), in particular, has…2022 American Transplant Congress
Secular Trends in Development of ESRD Following Liver Transplant
*Purpose: End-stage renal disease (ESRD) post-liver transplant (LT) is associated with increased mortality, but ESRD incidence and risk factors in LT recipients (LTRs) remain poorly…2022 American Transplant Congress
Cold Stress-Induced Ferroptosis in Liver Sinusoidal Endothelial Cells Deteriorates Liver Transplant Outcomes
UCLA Medical Center, Los Angeles, CA
*Purpose: While hepatocytes are affected by ischemia-reperfusion injury (IRI) especially under normothermic stress, liver sinusoidal endothelial cells (LSECs) are particularly vulnerable to cold storage-induced IR-insult.…2022 American Transplant Congress
Successful Utilization of Advanced Diabetes Technology to Optimize Glucose Control as a Bridge to Simultaneous Liver and Pancreas Transplantation
*Purpose: We present the case of a 20 year old female with history of autoimmune hepatitis diagnosed in 2014, treated with tacrolimus, and insulin dependent…2022 American Transplant Congress
Hypomethylated Regulatory Regions in Immune Signaling Genes Characterize Rejection Prone Pediatric Liver Transplant (LT) Recipients
*Purpose: Transcriptional regulation of LT rejection may reveal novel predictive and therapeutic targets. To identify signaling pathways which are differentially regulated by DNA methylation in…2022 American Transplant Congress
Temporal Trends of Optn Hope Act Variance Participation
*Purpose: The Organ Procurement and Transplantation Network (OPTN) created a research variance allowing for transplantation of HIV+ donor kidneys and livers into HIV+ recipients after…2022 American Transplant Congress
A Population-Based Analysis of Long-Term Outcomes Following Pediatric Acute Liver Failure Highlights High Risk Populations in Access to Transplant
*Purpose: Pediatric acute liver failure (PALF) is a potentially devastating illness that affects otherwise healthy children. Nearly 70% of children with PALF will recover, while…
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