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American Transplant Congress abstracts

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Articles tagged "Liver preservation"

  • 2019 American Transplant Congress

    Effectiveness Of The Vittal Viability Criteria During Ex Situ Normothermic Machine Perfusion To Discriminate Hepatobiliary Organ Injury And Investigation Of Biochemical Markers For Post-transplant Complications

    Y. L. Boteon, R. Laing, J. Attard, L. Wallace, A. Smith, M. Perera, D. Mirza, H. Mergental, S. Afford

    Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom

    *Purpose: The VITTAL (viability testing and transplantation of marginal livers) clinical trial demonstrated that ex situ end-ischaemic normothermic machine perfusion (NMP) allows functional assessment and…
  • 2019 American Transplant Congress

    Metabolic Profiling of Steatotic Human Livers during Ex-Vivo Normothermic Machine Perfusion

    S. Raigani1, N. Karimian2, V. Huang2, S. Geerts2, S. Nagpal2, K. Uygun1, M. Yarmush1, H. Yeh1

    1Transplant Surgery, Massachusetts General Hospital, Boston, MA, 2Center for Engineering in Medicine, Shriners Childrens Hospital, Boston, MA

    *Purpose: Nearly 40-60% of discarded livers are due to steatosis because of poor recovery from ischemia-reperfusion injury and compromised post-transplant function. We evaluated steatotic (ST)…
  • 2019 American Transplant Congress

    Pharmacological Enhancement of Bile Duct Preservation and Function during Ex-Situ Normothermic Machine Perfusion

    Y. L. Boteon, J. Attard, A. P. Boteon, L. Wallace, G. Reynolds, D. Mirza, H. Mergental, R. Bhogal, S. Afford

    Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom

    *Purpose: Whilst ex-situ normothermic machine perfusion (NMP) of the liver limits the ischaemic injury to the organ, benefits for biliary complications post-transplantation are not yet…
  • 2019 American Transplant Congress

    Combined Thoracic-Liver Transplants Using Normothermic Machine Perfusion for Liver Preservation: A Case Series

    M. Rizzari, K. Crombez, S. Nagai, J. Stracke, A. Al-Kurd, K. Collins, A. Yoshida, M. Abouljoud

    Henry Ford Transplant Institute, Detroit, MI

    *Purpose: There is minimal data describing combined thoracic-liver transplants (tx) with normothermic machine perfusion (NMP) used for liver preservation as the thoracic tx is done.…
  • 2018 American Transplant Congress

    A Cost Analysis on Normothermic Machine Perfusion at a Single Center

    D. Pezzati, Q. Liu, H. Hassan, G. Iuppa, L. Hernandez, G. D'Amico, T. Diago Uso, B. Heghtsad, C. Miller, C. Quintini.

    General Surgery, Cleveland Clinic, Cleveland, OH.

    INTRODUCTION: Normothermic machine perfusion (NMP) for liver transplantation is a novel and promising technique.One of the concerns related to its usage is the high cost.The…
  • 2018 American Transplant Congress

    Normothermic Ex Vivo Liver Perfusion Prior to Liver Transplantation Can Prevent Platelet Aggregation and Platelet Induced Sinusoidal Cell Injury

    D. Kollmann,1 I. Linares,1 S. Ganesh,1 R. Rosales,1 N. Tessandier,2 E. Boilard,2 M. Hamar,1 P. Urbanellis,1 P. Yip,3 O. Adeyi,3 M. Selzner,1 N. Selzner.1

    1Multi Organ Transplant, UHN, Toronto, Canada; 2Centre Hospitalier de l'Université Laval (CHUL), Québec, Canada; 3Laboratory Medicine and Pathobiology, UHN, Toronto, Canada.

    Background. Normothermic ex vivo liver perfusion (NEVLP) is a novel method for graft-preservation applied alternatively to static cold storage (SCS). We examined the impact of…
  • 2018 American Transplant Congress

    Improving DCD Livers Graft Function Using CD47 Blockade in the Setting of Normothermic Liver Perfusion

    S. Garcia-Aroz,1 M. Xu,1 X. Wang,1 J. Hollingshead,1 A. Khan,1 B. Banan,1 L. Kang,2 Z. Zhang,1 G. Upadhya,1 Y. Lin,1 P. Manning,3 W. Chapman.1

    1Surgery, Washington University, St. Louis; 2Pathology, Washington University, St. Louis; 3Arch Oncology, St. Louis.

    Background: Towards the goal of utilizing more livers for transplantation, transplant centers are looking to increase the use of organs from marginal donors. Livers from…
  • 2018 American Transplant Congress

    The First Series of Ischemia-Free Liver Transplantation in Human

    X. He,1 Z. Guo,1 S. Huang,1 Q. Zhao,1 Y. Tang,1 Z. Zhang,1 Z. Zhu,1 W. Ju,1 L. Yang,2 G. Chen.1

    1Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; 2Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

    BACKGROUND&AIMS: Ischemia and reperfusion injury (IRI) is known as an inevitable event leading to early and late graft failure. We have performed the first case…
  • 2018 American Transplant Congress

    One-Pump versus Two-Pump Normothermic Ex Vivo Perfusion Machines in Discarded Human Livers

    A. Hassan, Q. Liu, D. Pezzati, A. Nassar, B. Soliman, M. Blum, P. Grady, G. Iuppa, T. Uso, J. Fung, K. Abu-Elmagd, C. Quintini.

    Transplant Surgery, Cleveland Clinic, Cleveland.

    Introduction:Physiologic flows and pressures need to be provided by the ex vivo liver perfusion device. We hypothesized that the 1-pump designed machines would provide the…
  • 2018 American Transplant Congress

    Resuscitation and Viability Testing of Initially Declined Livers Using Sequential Hypo- and Normothermic Machine Perfusion with an Acellular Fluid

    Y. de Vries,1,2 A. Matton,1,2 S. Karangwa,1,2 M. Nijsten,3 R. de Kleine,2 A. van den Berg,4 V. de Meijer,2 P. Meyer,5 M. de Boer,2 R. Porte.2

    1Surgical Research Laboratory, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; 2Section of HPB Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, Netherlands; 3Department of Critical Care, University Medical Center Groningen, Groningen, Netherlands; 4Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, Netherlands; 5Department of Anesthesiology, University Medical Center Groningen, Groningen, Netherlands.

    While end-ischemic dual hypothermic oxygenated machine perfusion (DHOPE) resuscitates mitochondria and reduces ischemia-reperfusion injury, normothermic machine perfusion (NMP) allows for ex-situ functional testing of donor…
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