ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Liver preservation"

  • 2019 American Transplant Congress

    Effectiveness Of The Vittal Viability Criteria During Ex Situ Normothermic Machine Perfusion To Discriminate Hepatobiliary Organ Injury And Investigation Of Biochemical Markers For Post-transplant Complications

    Y. L. Boteon, R. Laing, J. Attard, L. Wallace, A. Smith, M. Perera, D. Mirza, H. Mergental, S. Afford

    Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom

    *Purpose: The VITTAL (viability testing and transplantation of marginal livers) clinical trial demonstrated that ex situ end-ischaemic normothermic machine perfusion (NMP) allows functional assessment and…
  • 2019 American Transplant Congress

    Metabolic Profiling of Steatotic Human Livers during Ex-Vivo Normothermic Machine Perfusion

    S. Raigani1, N. Karimian2, V. Huang2, S. Geerts2, S. Nagpal2, K. Uygun1, M. Yarmush1, H. Yeh1

    1Transplant Surgery, Massachusetts General Hospital, Boston, MA, 2Center for Engineering in Medicine, Shriners Childrens Hospital, Boston, MA

    *Purpose: Nearly 40-60% of discarded livers are due to steatosis because of poor recovery from ischemia-reperfusion injury and compromised post-transplant function. We evaluated steatotic (ST)…
  • 2019 American Transplant Congress

    Pharmacological Enhancement of Bile Duct Preservation and Function during Ex-Situ Normothermic Machine Perfusion

    Y. L. Boteon, J. Attard, A. P. Boteon, L. Wallace, G. Reynolds, D. Mirza, H. Mergental, R. Bhogal, S. Afford

    Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom

    *Purpose: Whilst ex-situ normothermic machine perfusion (NMP) of the liver limits the ischaemic injury to the organ, benefits for biliary complications post-transplantation are not yet…
  • 2019 American Transplant Congress

    Combined Thoracic-Liver Transplants Using Normothermic Machine Perfusion for Liver Preservation: A Case Series

    M. Rizzari, K. Crombez, S. Nagai, J. Stracke, A. Al-Kurd, K. Collins, A. Yoshida, M. Abouljoud

    Henry Ford Transplant Institute, Detroit, MI

    *Purpose: There is minimal data describing combined thoracic-liver transplants (tx) with normothermic machine perfusion (NMP) used for liver preservation as the thoracic tx is done.…
  • 2018 American Transplant Congress

    Human Atrial Natriuretic Peptide (hANP) in Cold Storage of Donation after Cardiac Death Livers: A New Tool for Protecting Vascular Endothelia?

    Y. Nigmet,1 K. Hata,1 Y. Okamura,1 I. Tamaki,1 T. Tsuruyama,2 H. Hirao,1 T. Kubota,1 J. Kusakabe,1 J. Yoshikawa,1 T. Goto,1 T. Tajima,1 H. Tanaka,1 S. Uemoto.1

    1Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kyoto University, Kyoto, Japan; 2Center for Anatomical, Pathological, and Forensic Medical Research, Kyoto University, Kyoto, Japan.

    Aim: Current critical shortage of donor organs has led to acceptance of donation after cardiac death (DCD) livers for transplantation. Human atrial natriuretic peptide (hANP)…
  • 2018 American Transplant Congress

    Supercooling of Human Livers to Extend the Preservation Time for Transplantation

    R. de Vries,1,2 S. Tessier,1,2 P. Banik,1,2 S. Ozer,1,2 S. Napgal,1,2 S. Cronin,1,2 J. Markmann,1,2 H. Yeh,1,2 K. Uygun.1,2

    1Department of Surgery, Massachusetts General Hospital, Boston, MA; 2Center for Engineering in Medicine, Harvard Medical School, Boston, MA.

    Introduction: Extending the maximum preservation time of donor organs could dramatically improve the outcome of organ transplantation. Static cold storage (SCS) at +5[deg]C is the…
  • 2018 American Transplant Congress

    The Role of Ex Vivo Normothermic Preservation in Minimizing Postreperfusion Syndrome in Liver Transplantation

    A. Hassan, J. Cywinski, Q. Liu, D. Pezzati, D. Yang, L. Liu, G. Iuppa, K. Hashimoto, F. Aucejo, M. Fujiki, B. Eghtesad, S. Irefin, J. Fung, K. Abu-Elmagd, C. Miller, C. Quintini.

    Transplant Surgery, Cleveland Clinic, Cleveland.

    Background:Graft reperfusion holds a major challenge during liver transplantation. NMP may improve post-reperfusion hemodynamics, reduce vasopressor and blood product transfusion.Methods:15 patients with liver transplantation after…
  • 2018 American Transplant Congress

    Assessment of Bile Production and Quality during Normothermic Ex Vivo Liver Perfusion to Predict Biliary Injury

    D. Kollmann,1 I. Linares,1 S. Ganesh,1 R. Rosales,1 M. Hamar,1 P. Urbanellis,1 A. Wiebe,1 P. Yip,2 O. Adeyi,2 M. Selzner,1 N. Selzner.1

    1Multi Organ Transplant Program, Toronto General Hospital, Toronto, Canada; 2Laboratory Medicine and Pathobiology, University Health Network, Toronto, Canada.

    Background. Liver transplantation (LT) with donation after circulatory death (DCD)-grafts is associated with higher risk for biliary strictures. We evaluated bile production and quality during…
  • 2018 American Transplant Congress

    A Cost Analysis on Normothermic Machine Perfusion at a Single Center

    D. Pezzati, Q. Liu, H. Hassan, G. Iuppa, L. Hernandez, G. D'Amico, T. Diago Uso, B. Heghtsad, C. Miller, C. Quintini.

    General Surgery, Cleveland Clinic, Cleveland, OH.

    INTRODUCTION: Normothermic machine perfusion (NMP) for liver transplantation is a novel and promising technique.One of the concerns related to its usage is the high cost.The…
  • 2018 American Transplant Congress

    Normothermic Ex Vivo Liver Perfusion Prior to Liver Transplantation Can Prevent Platelet Aggregation and Platelet Induced Sinusoidal Cell Injury

    D. Kollmann,1 I. Linares,1 S. Ganesh,1 R. Rosales,1 N. Tessandier,2 E. Boilard,2 M. Hamar,1 P. Urbanellis,1 P. Yip,3 O. Adeyi,3 M. Selzner,1 N. Selzner.1

    1Multi Organ Transplant, UHN, Toronto, Canada; 2Centre Hospitalier de l'Université Laval (CHUL), Québec, Canada; 3Laboratory Medicine and Pathobiology, UHN, Toronto, Canada.

    Background. Normothermic ex vivo liver perfusion (NEVLP) is a novel method for graft-preservation applied alternatively to static cold storage (SCS). We examined the impact of…
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