Articles tagged "Liver preservation"

2016 American Transplant Congress
Distinctive Roles of Gsk3 Inhibitory Phosphorylation in Liver Inflammatory Immune Response and Hepatocellular Injury Against Ischemia Reperfusion.
H. Zhou,^1,2 J. Zhu,¹ S. Yue,¹ R. Busuttil,¹ J. Kupiec-weglinski,¹ L. Lu,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-UCLA, Los Angeles, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Background & AimsGlycogen synthase kinase 3 (Gsk3) a and b are ubiquitously expressed, constitutively active serine/threonine kinases, which play complex roles in cell activation, proliferation…
2016 American Transplant Congress
Subnormothermic Machine Perfusion (SNMP) with a Hemoglobin Based Oxygen Carrier (HBOC) Solution Reprograms Dynamic Inflammation Networks When Compared to Cold Storage (CS) in a Porcine Liver Allograft Model.
D. Sadowsky, R. Zamora, B. Banan, D. Barclay, J. Yin, Y. Vodovotz, P. Fontes.
University of Pittsburgh, Pittsburgh.
Introduction: Inflammatory markers have been mostly studied by standard statistical analysis focused on single component variations. This study aimed to compare SNMP with CS regarding…
2015 American Transplant Congress
The Effect of Systemic Catecholamine Application On the Microcirculation in Liver Procurement
M. Strempel,¹ M. Kaths,¹ H. Lang,¹ G. Otto,¹ V. Weyer,² O. Kempski,³ A. Heimann,³ A. Schad,⁴ D. Foltys.¹
¹Department of Transplantation and Hepatobiliopancreatic Surgery, University Medical Centre, Johannes Gutenberg-University, Mainz, Germany; ²Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Johannes Gutenberg-University, Mainz, Germany; ³Institute of Neurosurgical Pathophysiology, University Medical Centre, Johannes Gutenberg-University, Mainz, Germany; ⁴Institute of Pathology, University Medical Centre, Johannes Gutenberg-University, Mainz, Germany.
Introduction: The most vulnerable part in liver transplantation remains the biliary system. There is evidence, that insufficient perfusion during multi-organ procurement plays a major role…
2015 American Transplant Congress
Normothermic Machine Perfusion (NMP) on Discarded Human Livers: The First Model in the US
Q. Liu, A. Nassar, G. Iuppa, D. Urcuyo-Llanes, D. Sexton, T. Okamoto, T. Uso, A. Bennett, W. Baldwin, K. Abu-Elmagd, J. Fung, C. Miller, C. Quintini.
Cleveland Clinic, Cleveland, OH.
The benefit of NMP preservation has been reported in a number of animal studies. Herein we describe safety, feasibility and effectiveness of NMP on discarded…
2015 American Transplant Congress
Hypothermic Machine Preservation Reduces Inflammatory, Hypoxic and Apoptotic Injuries in Human Liver Transplantation
J. Guarrera, C. Bae, S. Henry.
Center for Liver Disease and Transplantation, Columbia University Medical Center, New York, NY.
Introduction: Hypothermic machine perfusion (HMP) is in its infancy in Liver Transplantation. We analyzed all molecular samples from our cumulative clinical experience at Columbia University.Methods:…
2015 American Transplant Congress
"In-House" Controlled Oxygenated Rewarming After Initial Static Cold Storage: First Clinical Application in Marginal Donor Livers
D. Hoyer,¹ Z. Mathé,¹ A. Gallinat,¹ A. Canbay,² J. Treckmann,¹ U. Rauen,³ A. Paul,¹ T. Minor.⁴
¹General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany; ²Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany; ³Institute of Physiological Chemistry, University Hospital Essen, Essen, Germany; ⁴Surgical Research Division, University Hospital Bonn, Bonn, Germany.
IntroductionControlled oxygenated rewarming of cold stored livers by machine perfusion demonstrated a strong protective effect in preclinical studies. Here we report on the first clinical…
2015 American Transplant Congress
Somatostatin (Eumedica®) Infusion Allows Modulating Graft Flows and Gradients in Liver Transplantation. Results of a Randomized, Double Blind, Placebo Controlled Trial
R. Troisi,¹ A. Croo,¹ E. Codarin,³ E. De Wolf,¹ J. Van Limmen,⁴ G. Antoniali,³ B. Heyse,⁴ L. De Baerdemaeker,⁴ I. Colle,⁵ G. Tell,³ M. Sainz-Barriga.^1,2
¹General Hepatobiliary Surgery Liver Transplantation Service, Ghent University Hospital Medical School, Ghent, Belgium; ²Digestive Surgery & Liver Transplantation, University of Tours, Tours, France; ³Medical & Biological Sciences, University of Udine, Udine, Italy; ⁴Anesthesiology, Ghent University Hospital Medical School, Ghent, Belgium; ⁵Gastroenterology, Ghent University Hospital Medical School, Ghent, Belgium.
Background: Somatostatin (SST) infusion decrease portal pressure in acute variceal bleeding in cirrhotic patients. Despite liver transplantation (LTx), recipients with portal hypertension (PHT) display different…
2015 American Transplant Congress
Is Ex Vivo Liver Perfusion a Safe Alternative to Cold Static Storage for the Preservation of Standard Criteria Grafts?
N. Goldaracena, V. Spetzler, M. Kaths, J. Echeverri, M. Selzner.
Multi Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
Objective: Subnormothermic ex vivo liver perfusion (SNEVLP) has recently attracted great interest in the field of organ preservation for marginal grafts. However, data is lacking…
2015 American Transplant Congress
Evaluation of the Effects of N-Acetylcysteine Treatment in Adult Liver Transplant Recipients
E. Aldag, S. Farrell, R. Pedersen, A. Sahajpal, J. Clendenon, V. Gunabushanam, D. Kramer.
Aurora St Luke's Medical Center, Milwaukee, WI.
Background: N-acetylcysteine (NAC) has been used in post-orthotopic liver transplant (OLT) patients for the proposed mechanism of preventing tissue damage of the newly transplanted organ…
2015 American Transplant Congress
Diabetes Exacerbates Liver Ischemia and Reperfusion Injury By Activating the AGE-RAGE Pathway in Kupffer Cells
S. Yue, J. Zhu, J. Rao, J. Kupiec-Weglinski, R. Busuttil, Y. Zhai.
Surgery, UCLA, Los Angeles, CA.
Although pre-transplant diabetes has been documented as a risk factor for mortality post-liver transplant, the underlying mechanism remains obscure. In a murine liver partial warm…