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American Transplant Congress abstracts

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Articles tagged "Liver metabolism"

  • 2019 American Transplant Congress

    Indocyanine Green Fluorescence Imaging during Normothermic Ex Vivo Liver Perfusion for the Assessment of Hepatocyte, Biliary, and Vascular Function

    T. Goto, I. Linares, S. Ganesh, L. Mazilescu, P. Urbanellis, N. Selzner, M. Selzner

    Multi-Organ Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada

    *Purpose: Normothermic Ex Vivo Liver Perfusion (NEVLP) is a novel preservation for the storage and assessment of marginal grafts, such as Donation after Cardio-circulatory Death…
  • 2019 American Transplant Congress

    CD38 Inhibition: A Novel Target for Hepatic Ischemia Reperfusion Injury

    C. Akateh1, B. F. Reader1, Y. Lee1, J. Kim1, K. Maynard1, K. W. Washburn1, J. L. Zweier2, B. A. Whitson1, S. M. Black1

    1Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, 2The Ohio State University Wexner Medical Center, Columbus, OH

    *Purpose: Ischemia/reperfusion injury (IRI) is a major source of injury during many surgical procedures on the liver, and severe IRI can lead to post-hepatectomy liver…
  • 2019 American Transplant Congress

    Contribution of CD38 to Methionine Choline Deficient (MCD) Diet-Induced Liver Injury in Rats

    J. Kim, Y. Lee, B. F. Reader, C. Akateh, K. R. Maynard, K. W. Washburn, J. L. Zweier, B. A. Whitson, S. M. Black

    Department of Cardiac Surgery, The Ohio State Univ. Medical Center, Columbus, OH

    *Purpose: Nonalcoholic fatty liver disease (NAFLD) and associated non-alcoholic steatohepatitis (NASH) is a rising cause of end stage liver disease, increasing the need for liver…
  • 2019 American Transplant Congress

    Drug Metabolizing Capacity Of The Liver In Liver Donors Recovers Fully By One Month Post Donation

    M. Miah1, X. Wu1, I. H. Shaik1, H. J. Johnson1, S. Ganesh2, M. Molinari2, A. D. Tevar2, C. Hughes2, A. Humar2, R. Venkataramanan1

    1Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, 2Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA

    *Purpose: In liver donors, hepatic volume recovers to pre donation values in 2-6 months after surgery. However, there is limited information on the recovery of…
  • 2018 American Transplant Congress

    Hypothermic Machine Perfusion Protects DCD Liver Graft through Metabolism of Xenobiotics by Cytochrome P450 Pathway

    Q. Ye,1,2 W. Liang,1 Z. Zhong,1 S. Ye,1 B. Tang,1 Q. Hu,1 J. Liang,1 Y. Wang.1

    1Transplant Center of Wuhan University, Zhongnan Hospital of Wuhan University, Wuhan, China; 2The 3rd Xiangya Hospital of Central South Unversity, Changsha, China.

    Background: Donation after cardiac death (DCD) is the mainly resource to relieve organ-transplantation shortage. Our previous research have confirmed that the function of DCD liver…
  • 2017 American Transplant Congress

    Clearance of Transaminases During Normothermic Ex Vivo Liver Perfusion.

    M. Bral,1 N. Aboelnazar,2 B. Gala-Lopez,2 S. Hatami,2 D. Freed,1 A. Shapiro.1

    1Department of Transplant Surgery, University of Alberta, Edmonton, AB, Canada; 2Department of Experimental Surgery, University of Alberta, Edmonton, AB, Canada

    One of the most promising applications of normothermic ex vivo liver perfusion is the possibility of real-time graft viability assessment. Many liver biomarkers are considered…
  • 2017 American Transplant Congress

    Porcine Albumin Elaboration During Perfusion of Transgenic Porcine Livers with Human Blood.

    A. Cimeno,1 J. Powell,1 B. French,1 D. Ayares,2 A. Azimzadeh,1 R. Pierson III,1 R. Barth,1 J. LaMattina.

    1Department of Surgery, University of Maryland, School of Medicine, Baltimore, MD; 2Revivicor, Inc., Blacksburg, VA

    PurposeIn addition to immune barriers, molecular incompatibilities between species are predicted to limit pig liver survival in primate xenotransplantation models. How perfusion with human blood…
  • 2016 American Transplant Congress

    Metabolomic Profiles of Hepatocellular Carcinoma and Cirrhotic Patients Before and After Transplantation.

    C. Desai,1 R. Varghese,2 S. Robertazzi,1 C. Di Poto,2 A. Ferrarini,2 C. Tu,2 R. Girlanda,1 K. Khan,1 T. Fishbein,1 H. Ressom.2

    1Medstar Georgetown Transplant institute, Washington DC; 2Department of Oncology, Lombardi Comprehensive Cancer Center, Washington DC.

    Metabolomics offers the opportunity to characterize complex diseases like hepatocellular carcinoma (HCC) through a systematic evaluation of thousands of metabolites in human liver tissues and…
  • 2016 American Transplant Congress

    The Correlation of Hepatic and Systemic Hemodynamics During Liver Transplantation: Quantification of Hepatic Resistance as an Actual Value.

    A.-C. Feng, T.-W. Chen, H.-L. Fan, J.-C. Yu, C.-B. Hsieh.

    Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

    PurposeThe correlation between portal vein pressure (PVP) and flow (PVF) has not been established, and there is still lack of consensus about the optimal hemodynamics…
  • 2016 American Transplant Congress

    Metabolic Recovery and Ex Vivo Simulation of Early Liver Reperfusion.

    B. Bruinsma,1 J. Avruch,2 G. Sridharan,1 P. Weeder,1 N. Karimian,1 J. Markmann,2 K. Uygun,1 H. Yeh.2

    1Center for Engineering in Medicine, Massachusetts General Hospital, Boston, MA; 2Transplant Center, Massachusetts General Hospital, Boston, MA.

    Purpose. An urgent need for more liver grafts for transplantation has prompted the use of more suboptimal organs. Particularly in these more marginal livers adequate…
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