2022 American Transplant Congress
Donor Exercise Preconditioning Protects Murine Orthotopic Liver Grafts During Ischemia Reperfusion Injury
Surgery, University of Pittsburgh Medical Center, Pissburgh, PA
*Purpose: Orthotopic liver transplantation (LTx) serves as the gold standard of care in patients with end-stage liver disease. However, a major obstacle to the immediate…2022 American Transplant Congress
Optimization of Human Liver Organoid Model for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis
*Purpose: The aim of our project is to develop an in vitro 3D human liver organoid (3D-HLO) model for studying nonalcoholic fatty liver disease (NAFLD)…2022 American Transplant Congress
Tumor Suppressor Role of the Caveolar α1-na/k-atpase Signalosome in Nash Related Hepatocellular Carcinoma (HCC)
*Purpose: HCC is the second and fastest-growing cause of cancer- related mortality worldwide, with an estimate of 0.84million cases/year. In the Western countries, due to…2022 American Transplant Congress
Normothermic Machine Perfusion of the Liver Supports Protein Translation and Mitochondrial Function While Reducing Protein Degradation and Metabolic Imbalance: A Proteomics Study
*Purpose: Liver preservation by normothermic machine perfusion (NMP) involves perfusion of the graft with oxygenated blood and nutrients. The NMP Liver trial by the Consortium…2021 American Transplant Congress
Pre-transplant Prognostic Nutritional Index Predicts Short-term Outcomes After Liver Transplantation
Transplant Institute, Henry Ford Hospital, Detroit, MI
*Purpose: To understand the importance of pre-transplant nutritional status in optimizing liver transplant outcomes.*Methods: The prognostic nutritional index (PNI) is a serum marker of nutrition…2020 American Transplant Congress
Functional Changes in Metabolic and Malignancy Associated Bacterial Genes in the Post Transplant Intestinal Microbiome
*Purpose: Long-term survival of liver transplant (LT) recipients is affected by metabolic and malignant complications. The aim of our study was to examine changes in…2020 American Transplant Congress
Therapeutic Targeting of Bile Acid Metabolism Ameliorates Liver Ischemia/Reperfusion Injury
*Purpose: Farnesoid X receptor (FXR) is the major nuclear receptor of bile acids, which is also involved in the regulation of innate immune responses. As…2020 American Transplant Congress
Development of a Split Liver Machine Perfusion Protocol to Provide Comparative Controls in Assessing Therapeutic Interventions
*Purpose: Ex situ donor liver machine perfusion is developing into a promising tool to test organ viability prior to transplantation and vehicle to assess novel…2019 American Transplant Congress
The lncRNA-mRNA Co-Expression Analysis in Acetaminophen-Induced Liver Injury
*Purpose: Acetaminophen (APAP) could cause liver injury, or even acute liver failure, accounting for approximately one-half of all cases in developed countries. Once acute liver…2019 American Transplant Congress
Viability Testing and Transplantation of Marginal Donor Livers (VITTAL) Trial: Metabolomics of Ex Vivo Normothermically Machine Perfused Livers Discloses Molecular Signatures Predictive of Graft Viability and Post Transplant Outcomes
*Purpose: Donor organ shortage has led to increased reliance on high-risk livers for transplantation. Furthermore, emergence of machine perfusion has led to a paradigm shift…
American Transplant Congress abstracts