ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Liver metabolism"

  • 2020 American Transplant Congress

    Functional Changes in Metabolic and Malignancy Associated Bacterial Genes in the Post Transplant Intestinal Microbiome

    M. Bhat1, S. Sivaraj1, E. Pasini1, J. Copeland2, J. Allard3, A. Humar1

    1Multi-Organ Transplant, UHN, Toronto, ON, Canada, 2University of Toronto, Toronto, ON, Canada, 3UHN, Toronto, ON, Canada

    *Purpose: Long-term survival of liver transplant (LT) recipients is affected by metabolic and malignant complications. The aim of our study was to examine changes in…
  • 2020 American Transplant Congress

    Therapeutic Targeting of Bile Acid Metabolism Ameliorates Liver Ischemia/Reperfusion Injury

    M. Ni1, D. Jin2, T. Lu2, J. Zhang1, R. Busuttil1, J. Kupiec-Weglinski1, J. Zhang2, Y. Zhai1

    1Dumont-UCLA Transplant Center, Los Angeles, CA, 2Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

    *Purpose: Farnesoid X receptor (FXR) is the major nuclear receptor of bile acids, which is also involved in the regulation of innate immune responses. As…
  • 2020 American Transplant Congress

    Development of a Split Liver Machine Perfusion Protocol to Provide Comparative Controls in Assessing Therapeutic Interventions

    J. A. Attard1, L. Wallace1, Y. Boteon1, V. Ronca1, D. Osei-Bordom1, Y. Oo1, H. Mergental2, D. Mirza2, S. Afford1

    1Centre for Liver and Gastroenterology Research, University of Birmingham, Birmingham, United Kingdom, 2Liver Surgery Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom

    *Purpose: Ex situ donor liver machine perfusion is developing into a promising tool to test organ viability prior to transplantation and vehicle to assess novel…
  • 2019 American Transplant Congress

    Viability Testing and Transplantation of Marginal Donor Livers (VITTAL) Trial: Metabolomics of Ex Vivo Normothermically Machine Perfused Livers Discloses Molecular Signatures Predictive of Graft Viability and Post Transplant Outcomes

    J. Attard1, W. Dunn2, L. Wallace1, R. Laing1, Y. Boteon1, H. Mergental3, D. Mirza3, T. Perera3, S. Afford1

    1CLGR, University of Birmingham and NIHR Biomedical Research Centre, Birmingham, United Kingdom, 2Phenome Centre Birmingham, University of Birmingham, Birmingham, United Kingdom, 3Liver Unit, Queen Elizabeth University Hospital, Birmingham, United Kingdom

    *Purpose: Donor organ shortage has led to increased reliance on high-risk livers for transplantation. Furthermore, emergence of machine perfusion has led to a paradigm shift…
  • 2019 American Transplant Congress

    Indocyanine Green Fluorescence Imaging during Normothermic Ex Vivo Liver Perfusion for the Assessment of Hepatocyte, Biliary, and Vascular Function

    T. Goto, I. Linares, S. Ganesh, L. Mazilescu, P. Urbanellis, N. Selzner, M. Selzner

    Multi-Organ Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada

    *Purpose: Normothermic Ex Vivo Liver Perfusion (NEVLP) is a novel preservation for the storage and assessment of marginal grafts, such as Donation after Cardio-circulatory Death…
  • 2019 American Transplant Congress

    CD38 Inhibition: A Novel Target for Hepatic Ischemia Reperfusion Injury

    C. Akateh1, B. F. Reader1, Y. Lee1, J. Kim1, K. Maynard1, K. W. Washburn1, J. L. Zweier2, B. A. Whitson1, S. M. Black1

    1Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, 2The Ohio State University Wexner Medical Center, Columbus, OH

    *Purpose: Ischemia/reperfusion injury (IRI) is a major source of injury during many surgical procedures on the liver, and severe IRI can lead to post-hepatectomy liver…
  • 2019 American Transplant Congress

    Contribution of CD38 to Methionine Choline Deficient (MCD) Diet-Induced Liver Injury in Rats

    J. Kim, Y. Lee, B. F. Reader, C. Akateh, K. R. Maynard, K. W. Washburn, J. L. Zweier, B. A. Whitson, S. M. Black

    Department of Cardiac Surgery, The Ohio State Univ. Medical Center, Columbus, OH

    *Purpose: Nonalcoholic fatty liver disease (NAFLD) and associated non-alcoholic steatohepatitis (NASH) is a rising cause of end stage liver disease, increasing the need for liver…
  • 2019 American Transplant Congress

    Drug Metabolizing Capacity Of The Liver In Liver Donors Recovers Fully By One Month Post Donation

    M. Miah1, X. Wu1, I. H. Shaik1, H. J. Johnson1, S. Ganesh2, M. Molinari2, A. D. Tevar2, C. Hughes2, A. Humar2, R. Venkataramanan1

    1Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, 2Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA

    *Purpose: In liver donors, hepatic volume recovers to pre donation values in 2-6 months after surgery. However, there is limited information on the recovery of…
  • 2019 American Transplant Congress

    The lncRNA-mRNA Co-Expression Analysis in Acetaminophen-Induced Liver Injury

    J. Zheng, F. Xue

    Liver Surgery and Liver Transplantation Center, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

    *Purpose: Acetaminophen (APAP) could cause liver injury, or even acute liver failure, accounting for approximately one-half of all cases in developed countries. Once acute liver…
  • 2018 American Transplant Congress

    Hypothermic Machine Perfusion Protects DCD Liver Graft through Metabolism of Xenobiotics by Cytochrome P450 Pathway

    Q. Ye,1,2 W. Liang,1 Z. Zhong,1 S. Ye,1 B. Tang,1 Q. Hu,1 J. Liang,1 Y. Wang.1

    1Transplant Center of Wuhan University, Zhongnan Hospital of Wuhan University, Wuhan, China; 2The 3rd Xiangya Hospital of Central South Unversity, Changsha, China.

    Background: Donation after cardiac death (DCD) is the mainly resource to relieve organ-transplantation shortage. Our previous research have confirmed that the function of DCD liver…
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