2020 American Transplant Congress
Functional Changes in Metabolic and Malignancy Associated Bacterial Genes in the Post Transplant Intestinal Microbiome
*Purpose: Long-term survival of liver transplant (LT) recipients is affected by metabolic and malignant complications. The aim of our study was to examine changes in…2020 American Transplant Congress
Therapeutic Targeting of Bile Acid Metabolism Ameliorates Liver Ischemia/Reperfusion Injury
*Purpose: Farnesoid X receptor (FXR) is the major nuclear receptor of bile acids, which is also involved in the regulation of innate immune responses. As…2020 American Transplant Congress
Development of a Split Liver Machine Perfusion Protocol to Provide Comparative Controls in Assessing Therapeutic Interventions
*Purpose: Ex situ donor liver machine perfusion is developing into a promising tool to test organ viability prior to transplantation and vehicle to assess novel…2019 American Transplant Congress
Viability Testing and Transplantation of Marginal Donor Livers (VITTAL) Trial: Metabolomics of Ex Vivo Normothermically Machine Perfused Livers Discloses Molecular Signatures Predictive of Graft Viability and Post Transplant Outcomes
*Purpose: Donor organ shortage has led to increased reliance on high-risk livers for transplantation. Furthermore, emergence of machine perfusion has led to a paradigm shift…2019 American Transplant Congress
Indocyanine Green Fluorescence Imaging during Normothermic Ex Vivo Liver Perfusion for the Assessment of Hepatocyte, Biliary, and Vascular Function
Multi-Organ Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada
*Purpose: Normothermic Ex Vivo Liver Perfusion (NEVLP) is a novel preservation for the storage and assessment of marginal grafts, such as Donation after Cardio-circulatory Death…2019 American Transplant Congress
CD38 Inhibition: A Novel Target for Hepatic Ischemia Reperfusion Injury
*Purpose: Ischemia/reperfusion injury (IRI) is a major source of injury during many surgical procedures on the liver, and severe IRI can lead to post-hepatectomy liver…2019 American Transplant Congress
Contribution of CD38 to Methionine Choline Deficient (MCD) Diet-Induced Liver Injury in Rats
Department of Cardiac Surgery, The Ohio State Univ. Medical Center, Columbus, OH
*Purpose: Nonalcoholic fatty liver disease (NAFLD) and associated non-alcoholic steatohepatitis (NASH) is a rising cause of end stage liver disease, increasing the need for liver…2019 American Transplant Congress
Drug Metabolizing Capacity Of The Liver In Liver Donors Recovers Fully By One Month Post Donation
*Purpose: In liver donors, hepatic volume recovers to pre donation values in 2-6 months after surgery. However, there is limited information on the recovery of…2019 American Transplant Congress
The lncRNA-mRNA Co-Expression Analysis in Acetaminophen-Induced Liver Injury
*Purpose: Acetaminophen (APAP) could cause liver injury, or even acute liver failure, accounting for approximately one-half of all cases in developed countries. Once acute liver…2018 American Transplant Congress
Hypothermic Machine Perfusion Protects DCD Liver Graft through Metabolism of Xenobiotics by Cytochrome P450 Pathway
Background: Donation after cardiac death (DCD) is the mainly resource to relieve organ-transplantation shortage. Our previous research have confirmed that the function of DCD liver…
American Transplant Congress abstracts