Liver metabolism Archives

2018 American Transplant Congress
Hypothermic Machine Perfusion Protects DCD Liver Graft through Metabolism of Xenobiotics by Cytochrome P450 Pathway
Q. Ye,^1,2 W. Liang,¹ Z. Zhong,¹ S. Ye,¹ B. Tang,¹ Q. Hu,¹ J. Liang,¹ Y. Wang.¹
¹Transplant Center of Wuhan University, Zhongnan Hospital of Wuhan University, Wuhan, China; ²The 3rd Xiangya Hospital of Central South Unversity, Changsha, China.
Background: Donation after cardiac death (DCD) is the mainly resource to relieve organ-transplantation shortage. Our previous research have confirmed that the function of DCD liver…
2017 American Transplant Congress
Clearance of Transaminases During Normothermic Ex Vivo Liver Perfusion.
M. Bral,¹ N. Aboelnazar,² B. Gala-Lopez,² S. Hatami,² D. Freed,¹ A. Shapiro.¹
¹Department of Transplant Surgery, University of Alberta, Edmonton, AB, Canada; ²Department of Experimental Surgery, University of Alberta, Edmonton, AB, Canada
One of the most promising applications of normothermic ex vivo liver perfusion is the possibility of real-time graft viability assessment. Many liver biomarkers are considered…
2017 American Transplant Congress
Porcine Albumin Elaboration During Perfusion of Transgenic Porcine Livers with Human Blood.
A. Cimeno,¹ J. Powell,¹ B. French,¹ D. Ayares,² A. Azimzadeh,¹ R. Pierson III,¹ R. Barth,¹ J. LaMattina.
¹Department of Surgery, University of Maryland, School of Medicine, Baltimore, MD; ²Revivicor, Inc., Blacksburg, VA
PurposeIn addition to immune barriers, molecular incompatibilities between species are predicted to limit pig liver survival in primate xenotransplantation models. How perfusion with human blood…
2016 American Transplant Congress
Lipid Metabolism and Preservation of Discarded Steatotic Human Livers Using 24 Hours Ex-Vivo Normothermic Machine Perfusion.
Q. Liu, A. Nassar, G. Iuppa, B. Soliman, L. Buccini, M. Blum, T. Okamoto, T. Uso, A. Bennett, W. Baldwin, K. Abu-Elmagd, J. Fung, C. Miller, C. Quintini.
Cleveland Clinic, Cleveland, OH.
One primary reason to discard donor livers after procurement is severe steatosis. The impact of normothermic machine perfusion (NMP) on lipid metabolism and preservation of…
2016 American Transplant Congress
Metabolic Recovery and Ex Vivo Simulation of Early Liver Reperfusion.
B. Bruinsma,¹ J. Avruch,² G. Sridharan,¹ P. Weeder,¹ N. Karimian,¹ J. Markmann,² K. Uygun,¹ H. Yeh.²
¹Center for Engineering in Medicine, Massachusetts General Hospital, Boston, MA; ²Transplant Center, Massachusetts General Hospital, Boston, MA.
Purpose. An urgent need for more liver grafts for transplantation has prompted the use of more suboptimal organs. Particularly in these more marginal livers adequate…
2016 American Transplant Congress
The Correlation of Hepatic and Systemic Hemodynamics During Liver Transplantation: Quantification of Hepatic Resistance as an Actual Value.
A.-C. Feng, T.-W. Chen, H.-L. Fan, J.-C. Yu, C.-B. Hsieh.
Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
PurposeThe correlation between portal vein pressure (PVP) and flow (PVF) has not been established, and there is still lack of consensus about the optimal hemodynamics…
2016 American Transplant Congress
Metabolomic Profiles of Hepatocellular Carcinoma and Cirrhotic Patients Before and After Transplantation.
C. Desai,¹ R. Varghese,² S. Robertazzi,¹ C. Di Poto,² A. Ferrarini,² C. Tu,² R. Girlanda,¹ K. Khan,¹ T. Fishbein,¹ H. Ressom.²
¹Medstar Georgetown Transplant institute, Washington DC; ²Department of Oncology, Lombardi Comprehensive Cancer Center, Washington DC.
Metabolomics offers the opportunity to characterize complex diseases like hepatocellular carcinoma (HCC) through a systematic evaluation of thousands of metabolites in human liver tissues and…

Articles tagged "Liver metabolism"