2019 American Transplant Congress
Viability Testing and Transplantation of Marginal Donor Livers (VITTAL) Trial: Metabolomics of Ex Vivo Normothermically Machine Perfused Livers Discloses Molecular Signatures Predictive of Graft Viability and Post Transplant Outcomes
*Purpose: Donor organ shortage has led to increased reliance on high-risk livers for transplantation. Furthermore, emergence of machine perfusion has led to a paradigm shift…2019 American Transplant Congress
Indocyanine Green Fluorescence Imaging during Normothermic Ex Vivo Liver Perfusion for the Assessment of Hepatocyte, Biliary, and Vascular Function
Multi-Organ Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada
*Purpose: Normothermic Ex Vivo Liver Perfusion (NEVLP) is a novel preservation for the storage and assessment of marginal grafts, such as Donation after Cardio-circulatory Death…2019 American Transplant Congress
CD38 Inhibition: A Novel Target for Hepatic Ischemia Reperfusion Injury
*Purpose: Ischemia/reperfusion injury (IRI) is a major source of injury during many surgical procedures on the liver, and severe IRI can lead to post-hepatectomy liver…2019 American Transplant Congress
Contribution of CD38 to Methionine Choline Deficient (MCD) Diet-Induced Liver Injury in Rats
Department of Cardiac Surgery, The Ohio State Univ. Medical Center, Columbus, OH
*Purpose: Nonalcoholic fatty liver disease (NAFLD) and associated non-alcoholic steatohepatitis (NASH) is a rising cause of end stage liver disease, increasing the need for liver…2019 American Transplant Congress
Drug Metabolizing Capacity Of The Liver In Liver Donors Recovers Fully By One Month Post Donation
*Purpose: In liver donors, hepatic volume recovers to pre donation values in 2-6 months after surgery. However, there is limited information on the recovery of…2019 American Transplant Congress
The lncRNA-mRNA Co-Expression Analysis in Acetaminophen-Induced Liver Injury
*Purpose: Acetaminophen (APAP) could cause liver injury, or even acute liver failure, accounting for approximately one-half of all cases in developed countries. Once acute liver…2018 American Transplant Congress
Hypothermic Machine Perfusion Protects DCD Liver Graft through Metabolism of Xenobiotics by Cytochrome P450 Pathway
Background: Donation after cardiac death (DCD) is the mainly resource to relieve organ-transplantation shortage. Our previous research have confirmed that the function of DCD liver…2017 American Transplant Congress
Clearance of Transaminases During Normothermic Ex Vivo Liver Perfusion.
One of the most promising applications of normothermic ex vivo liver perfusion is the possibility of real-time graft viability assessment. Many liver biomarkers are considered…2017 American Transplant Congress
Porcine Albumin Elaboration During Perfusion of Transgenic Porcine Livers with Human Blood.
PurposeIn addition to immune barriers, molecular incompatibilities between species are predicted to limit pig liver survival in primate xenotransplantation models. How perfusion with human blood…2016 American Transplant Congress
Lipid Metabolism and Preservation of Discarded Steatotic Human Livers Using 24 Hours Ex-Vivo Normothermic Machine Perfusion.
Cleveland Clinic, Cleveland, OH.
One primary reason to discard donor livers after procurement is severe steatosis. The impact of normothermic machine perfusion (NMP) on lipid metabolism and preservation of…
American Transplant Congress abstracts