Articles tagged "Liver metabolism"

2022 American Transplant Congress
Donor Exercise Preconditioning Protects Murine Orthotopic Liver Grafts During Ischemia Reperfusion Injury
H. O. Yazdani, C. Kaltenmeier, R. Nakano, R. L. Simmons, D. A. Geller, S. Tohme
Surgery, University of Pittsburgh Medical Center, Pissburgh, PA
*Purpose: Orthotopic liver transplantation (LTx) serves as the gold standard of care in patients with end-stage liver disease. However, a major obstacle to the immediate…
2022 American Transplant Congress
Optimization of Human Liver Organoid Model for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis
Y. Park¹, D. Thadasina¹, K. Isidan¹, K. J. Lopez¹, A. Cross-Najafi¹, P. Li¹, H. Francis², G. Alpini², W. Zhang¹, B. Ekser¹
¹Surgery, Indiana University School of Medicine, Indianapolis, IN, ²Division of Gastroenterology & Hepatology, Indiana University School of Medicine, Indianapolis, IN
*Purpose: The aim of our project is to develop an in vitro 3D human liver organoid (3D-HLO) model for studying nonalcoholic fatty liver disease (NAFLD)…
2022 American Transplant Congress
Tumor Suppressor Role of the Caveolar α1-na/k-atpase Signalosome in Nash Related Hepatocellular Carcinoma (HCC)
U. Udoh¹, M. Banerjee¹, J. D. Sanabria¹, P. K. Rajan¹, M. Schade², J. A. Sanabria³, S. Pierre³, J. R. Sanabria⁴
¹Surgery, Marshall Institute for Interdisciplinary Research, Barboursville, WV, ²Medicine, Joan C. Edwards School of Medicine, Marshall University, Barboursville, WV, ³Surgery, Joan C. Edwards School of Medicine, Marshall University, Barboursville, WV, ⁴Surgery, Joan C. Edwards School of Medicine, Marshall University and Case Western Reserve University, Barboursville, WV
*Purpose: HCC is the second and fastest-growing cause of cancer- related mortality worldwide, with an estimate of 0.84million cases/year. In the Western countries, due to…
2022 American Transplant Congress
Normothermic Machine Perfusion of the Liver Supports Protein Translation and Mitochondrial Function While Reducing Protein Degradation and Metabolic Imbalance: A Proteomics Study
L. Lo Faro¹, A. Thorne², H. Huang³, P. Charles³, M. Kaisar¹, S. Davis³, F. Dengu¹, S. Shaheed¹, J. Mulvey¹, R. Fischer³, D. Nasralla⁴, B. Kessler³, H. Leuvenink², P. Friend¹, R. Ploeg¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ²University Medical Center Groningen, Groningen, Netherlands, ³Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, ⁴Royal Free London NHS Foundation Trust, London, United Kingdom
*Purpose: Liver preservation by normothermic machine perfusion (NMP) involves perfusion of the graft with oxygenated blood and nutrients. The NMP Liver trial by the Consortium…
2021 American Transplant Congress
Pre-transplant Prognostic  Nutritional  Index  Predicts  Short-term  Outcomes  After  Liver Transplantation
E. Lisznyai, T. Kitajima, K. Delvecchio, A. Mohamed, S. Yeddula, T. Shamaa, T. Ivanics, K. Collins, M. Rizzari, A. Yoshida, M. Abouljoud, S. Nagai
Transplant Institute, Henry Ford Hospital, Detroit, MI
*Purpose: To understand the importance of pre-transplant nutritional status in optimizing liver transplant outcomes.*Methods: The prognostic nutritional index (PNI) is a  serum  marker of nutrition…
2020 American Transplant Congress
Functional Changes in Metabolic and Malignancy Associated Bacterial Genes in the Post Transplant Intestinal Microbiome
M. Bhat¹, S. Sivaraj¹, E. Pasini¹, J. Copeland², J. Allard³, A. Humar¹
¹Multi-Organ Transplant, UHN, Toronto, ON, Canada, ²University of Toronto, Toronto, ON, Canada, ³UHN, Toronto, ON, Canada
*Purpose: Long-term survival of liver transplant (LT) recipients is affected by metabolic and malignant complications. The aim of our study was to examine changes in…
2020 American Transplant Congress
Therapeutic Targeting of Bile Acid Metabolism Ameliorates Liver Ischemia/Reperfusion Injury
M. Ni¹, D. Jin², T. Lu², J. Zhang¹, R. Busuttil¹, J. Kupiec-Weglinski¹, J. Zhang², Y. Zhai¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
*Purpose: Farnesoid X receptor (FXR) is the major nuclear receptor of bile acids, which is also involved in the regulation of innate immune responses. As…
2020 American Transplant Congress
Development of a Split Liver Machine Perfusion Protocol to Provide Comparative Controls in Assessing Therapeutic Interventions
J. A. Attard¹, L. Wallace¹, Y. Boteon¹, V. Ronca¹, D. Osei-Bordom¹, Y. Oo¹, H. Mergental², D. Mirza², S. Afford¹
¹Centre for Liver and Gastroenterology Research, University of Birmingham, Birmingham, United Kingdom, ²Liver Surgery Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom
*Purpose: Ex situ donor liver machine perfusion is developing into a promising tool to test organ viability prior to transplantation and vehicle to assess novel…
2019 American Transplant Congress
Indocyanine Green Fluorescence Imaging during Normothermic Ex Vivo Liver Perfusion for the Assessment of Hepatocyte, Biliary, and Vascular Function
T. Goto, I. Linares, S. Ganesh, L. Mazilescu, P. Urbanellis, N. Selzner, M. Selzner
Multi-Organ Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada
*Purpose: Normothermic Ex Vivo Liver Perfusion (NEVLP) is a novel preservation for the storage and assessment of marginal grafts, such as Donation after Cardio-circulatory Death…
2019 American Transplant Congress
CD38 Inhibition: A Novel Target for Hepatic Ischemia Reperfusion Injury
C. Akateh¹, B. F. Reader¹, Y. Lee¹, J. Kim¹, K. Maynard¹, K. W. Washburn¹, J. L. Zweier², B. A. Whitson¹, S. M. Black¹
¹Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, ²The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: Ischemia/reperfusion injury (IRI) is a major source of injury during many surgical procedures on the liver, and severe IRI can lead to post-hepatectomy liver…