Articles tagged "Liver failure"

2020 American Transplant Congress
In a Murine Model of Acetaminophen-Mediated Liver Injury, Tubastatin-a, An Hdac6-Specific Inhibitor, Improves Survival and Decreases Hepatocellular Injury
C. S. OBrien¹, P. T. Hernandez¹, S. J. Concors¹, L. N. Krumeich¹, Z. Wang¹, G. Ge¹, T. Bhatti², A. Kozikowski³, W. Hancock², M. H. Levine¹
¹Department of Surgery, University of Pennsylvania, Philadelphia, PA, ²Department of Pathology, Children's Hospital of Pennsylvania, Philadelphia, PA, ³Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL
*Purpose: Tylenol (APAP) toxicity, due to its narrow therapeutic window, is the leading cause of acute liver failure in the United States, resulting in approximately…
2020 American Transplant Congress
Ex-Vivo Perfusion with UW Cold Storage Solution Improves DCD Rat Liver Preservation
R. Fyffe-Freil, N. Wickramaratne, J. Khoraki, H. Kang, C. Chmielewski, R. Li, M. J. Mangino
Surgery, Virginia Commonwealth University, Richmond, VA
*Purpose: The donor pool of livers can be expanded by the successful use of donor livers recovered under DCD conditions. It is assumed that perfusion…
2020 American Transplant Congress
Karnofsky Performance Status Significantly Increases Waitlist Mortality among Different Grades of Acute on Chronic Liver Failure
A. Ashhab¹, R. Wong², V. Sundaram¹
¹Cedars Sinai Medical Center, Los Angeles, CA, ²Alameida Health System, Oakland, CA
*Purpose: Acute on chronic liver failure (ACLF) is a condition associated with high waitlist mortality and graded according to the number of organ system failures…
2020 American Transplant Congress
Improved Survival of Acute Liver Failure by “Off-the-Shelf” Bioartificial Liver Support System Using Immobilized Cryopreserved Hepatocyte Spheroids in Porcine Model
S. Lee¹, J. Lee², H. Park², Y. Kim², J. Noh³, J. Jung³, S. Lee³, H. Shin³, H. Yoon⁴, D. Lee³, S. Lee¹
¹Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of, ²Stem Cell and Regenerative Medicine Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea, Republic of, ³Biomedical Research Center, Lifeliver, Co. Ltd., Yongin, Korea, Republic of, ⁴Biomedical Research Center, Lifeliver, Co. Ltd., Seoul, Korea, Republic of
*Purpose: Acute liver failure (ALF) has a rapid and unpredictable onset with high mortality. The only current treatment is to transplant a donor organ but…
2020 American Transplant Congress
Comparison of Clinical Outcomes of Induction Regimens in Patients Undergoing Liver Transplantation for Acute Liver Failure
C. M. Anugwom¹, J. Parekh², C. Hwang³, M. MacConmara³, W. M. Lee⁴, T. M. Leventhal¹
¹Gastroenterology, Hepatology and Nutrition, University of Minnesota Medical Center, Minneapolis, MN, ²Department of Surgery, University of California, San Diego, San Diego, CA, ³Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, ⁴Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX
*Purpose: Spontaneous survival rates in acute liver failure (ALF) are vastly improved by liver transplantation (LT). However, the value of induction agents beyond steroids continues…
2020 American Transplant Congress
Rare Case of Donor Transmission of Hepatitis a Virus in Two Kidney Transplant Recipients
A. Kumar, S. Rao, A. Nishio Lucar, C. Argo, M. Poulter, A. Doyle
University of Virginia, Charlottesville, VA
*Purpose: Infectious transmission via solid organ transplant (SOT) remains an inherent risk of transplantation despite measures to mitigate the risk. We report a rare case…
2020 American Transplant Congress
Acute Liver Failure Requiring Liver Transplantation Due to Acute Hepatitis A Infection: A Case Series
C. Xie¹, J. M. Fenkel¹, D. L. Halegoua-DeMarzio¹, J. M. Civan¹, D. M. Tholey¹, S. K. Herrine¹, M. Thapar¹, S. Arastu¹, A. M. Frank², A. P. Shah², J. M. Glorioso², C. G. Ramirez², A. S. Bodzin², W. R. Maley², D. A. Sass¹
¹Gastroenterology and Hepatology, Thomas Jefferson University, Philadelphia, PA, ²Transplant Surgery, Thomas Jefferson University, Philadelphia, PA
*Purpose: On August 1, Philadelphia declared a public health emergency regarding rapid increases in new acute hepatitis A virus (HAV) cases, with 355 locally-acquired cases…
2020 American Transplant Congress
Small RNA Extracellular Vesicles Isolated from Liver Perfusate Provides Assessment of Organ Quality and Post Transplantation Graft Function
A. Bajwa, C. Kuscu, C. Kuscu, A. R. Wolen, J. D. Eason, D. Maluf, V. Mas
Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN
*Purpose: Donor quality plays a critical role during IRI and early graft outcomes. Extracellular vesicles (EVs) provide a novel source of valuable biomarkers that may…
2020 American Transplant Congress
Liver Transplantation as a Salvage and Uncommon Procedure for a Patient with Colorectal Liver Metastsis with Promising Results, Case Presentation and Literature Review
M. Tabbal, M. Al Qahtani
Transplant Surgery, King Fahad Specialist Hospital Dammam, Dammam, Saudi Arabia
*Purpose: Colorectal cancer (CRC) is the third most common cancer worldwide. About 50% of patients with CRC will develop metastases during the course of the…
2020 American Transplant Congress
Factors Associated with High Mortality in Acute on Chronic Liver Failure Patients Admitted to the Intensive Care Unit, Single Center Experience
O. Mendez Guerrero, D. A. Calle Rodas, E. Cervantes Alvarez, E. Alatorre Arenas, J. Perez Escobar, A. Estanes Hernandez, N. Navarro Alvarez, A. Torre
Hepatology and Liver Transplantation Unit, Gastroenterology department, National Institute of Medical Science and Nutrition Salvador Zubiran, Mexico City, Mexico
*Purpose: ACLF is a newly defined syndrome in the background of a chronic liver disease characterized by acute decompensation, organ failure and high mortality at…