Articles tagged "Liver failure"

2020 American Transplant Congress
Acute on Chronic Liver Failure (ACLF) Patients Have a Dynamic and Progressive Clinical Course Until Receiving a Liver Transplant: A 5-Year Study at the National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico
E. Cervantes-Alvarez¹, M. J. Lizardo-Thiebaud¹, E. Alatorre-Arenas¹, O. Mendez-Guerrero¹, S. Yarza-Regalado¹, A. Torre¹, M. Vilatobá², D. Kershenobich¹, C. A. Huang³, N. Navarro-Alvarez¹
¹Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ²Surgery, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ³Surgery, University of Colorado Anschutz Medical Campus, DENVER, CO
*Purpose: To characterize the clinical course of patients diagnosed with acute on chronic liver failure (ACLF) before undergoing liver transplantation. ACLF is characterized by an…
2020 American Transplant Congress
Galectin-3 as a Biomarker of Disease Severity in Acute-on-Chronic Liver Failure
E. Cervantes-Alvarez¹, F. Tejeda-Dominguez², M. Lizardo-Thiebaud², E. Alatorre-Arenas³, O. Méndez-Guerrero¹, S. Yarza-Regalado¹, D. Kershenobich¹, A. Torre¹, M. Vilatobá⁴, C. A. Huang⁵, N. Navarro-Alvarez¹
¹Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ²Molecular Biology, Panamerican University, School of Medicine, Mexico City, Mexico, ³University of the Americas Puebla, School of Medicine, Puebla, Mexico, ⁴Surgery, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ⁵Surgery, University of Colorado Anschutz Medical Campus, Denver, CO
*Purpose: A matter of great importance is the discovery of alternative diagnostic measures that can detect liver disease at an early stage, especially when at…
2020 American Transplant Congress
Rare Genetic Mutation Triggering Acute Liver Failure in a Toddler Needing a Liver Transplant
C. B. Chen¹, N. Mistry Ambani¹, A. Zeft¹, R. Garcia-Naviero², V. Hupertz¹, K. Hashimoto¹, K. Radhakrishnan¹
¹Cleveland Clinic, Cleveland, OH, ²Akron Children's Hospital, Akron, OH
*Purpose: The AIRE gene plays an important role in immune tolerance by driving negative selection of self-recognizing T-cells. Mutations in this gene are responsible for…
2020 American Transplant Congress
In a Murine Model of Acetaminophen-Mediated Liver Injury, Tubastatin-a, An Hdac6-Specific Inhibitor, Improves Survival and Decreases Hepatocellular Injury
C. S. OBrien¹, P. T. Hernandez¹, S. J. Concors¹, L. N. Krumeich¹, Z. Wang¹, G. Ge¹, T. Bhatti², A. Kozikowski³, W. Hancock², M. H. Levine¹
¹Department of Surgery, University of Pennsylvania, Philadelphia, PA, ²Department of Pathology, Children's Hospital of Pennsylvania, Philadelphia, PA, ³Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL
*Purpose: Tylenol (APAP) toxicity, due to its narrow therapeutic window, is the leading cause of acute liver failure in the United States, resulting in approximately…
2020 American Transplant Congress
Ex-Vivo Perfusion with UW Cold Storage Solution Improves DCD Rat Liver Preservation
R. Fyffe-Freil, N. Wickramaratne, J. Khoraki, H. Kang, C. Chmielewski, R. Li, M. J. Mangino
Surgery, Virginia Commonwealth University, Richmond, VA
*Purpose: The donor pool of livers can be expanded by the successful use of donor livers recovered under DCD conditions. It is assumed that perfusion…
2020 American Transplant Congress
Karnofsky Performance Status Significantly Increases Waitlist Mortality among Different Grades of Acute on Chronic Liver Failure
A. Ashhab¹, R. Wong², V. Sundaram¹
¹Cedars Sinai Medical Center, Los Angeles, CA, ²Alameida Health System, Oakland, CA
*Purpose: Acute on chronic liver failure (ACLF) is a condition associated with high waitlist mortality and graded according to the number of organ system failures…
2020 American Transplant Congress
Improved Survival of Acute Liver Failure by “Off-the-Shelf” Bioartificial Liver Support System Using Immobilized Cryopreserved Hepatocyte Spheroids in Porcine Model
S. Lee¹, J. Lee², H. Park², Y. Kim², J. Noh³, J. Jung³, S. Lee³, H. Shin³, H. Yoon⁴, D. Lee³, S. Lee¹
¹Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of, ²Stem Cell and Regenerative Medicine Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea, Republic of, ³Biomedical Research Center, Lifeliver, Co. Ltd., Yongin, Korea, Republic of, ⁴Biomedical Research Center, Lifeliver, Co. Ltd., Seoul, Korea, Republic of
*Purpose: Acute liver failure (ALF) has a rapid and unpredictable onset with high mortality. The only current treatment is to transplant a donor organ but…
2020 American Transplant Congress
Comparison of Clinical Outcomes of Induction Regimens in Patients Undergoing Liver Transplantation for Acute Liver Failure
C. M. Anugwom¹, J. Parekh², C. Hwang³, M. MacConmara³, W. M. Lee⁴, T. M. Leventhal¹
¹Gastroenterology, Hepatology and Nutrition, University of Minnesota Medical Center, Minneapolis, MN, ²Department of Surgery, University of California, San Diego, San Diego, CA, ³Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, ⁴Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX
*Purpose: Spontaneous survival rates in acute liver failure (ALF) are vastly improved by liver transplantation (LT). However, the value of induction agents beyond steroids continues…
2020 American Transplant Congress
Rare Case of Donor Transmission of Hepatitis a Virus in Two Kidney Transplant Recipients
A. Kumar, S. Rao, A. Nishio Lucar, C. Argo, M. Poulter, A. Doyle
University of Virginia, Charlottesville, VA
*Purpose: Infectious transmission via solid organ transplant (SOT) remains an inherent risk of transplantation despite measures to mitigate the risk. We report a rare case…
2020 American Transplant Congress
Acute Liver Failure Requiring Liver Transplantation Due to Acute Hepatitis A Infection: A Case Series
C. Xie¹, J. M. Fenkel¹, D. L. Halegoua-DeMarzio¹, J. M. Civan¹, D. M. Tholey¹, S. K. Herrine¹, M. Thapar¹, S. Arastu¹, A. M. Frank², A. P. Shah², J. M. Glorioso², C. G. Ramirez², A. S. Bodzin², W. R. Maley², D. A. Sass¹
¹Gastroenterology and Hepatology, Thomas Jefferson University, Philadelphia, PA, ²Transplant Surgery, Thomas Jefferson University, Philadelphia, PA
*Purpose: On August 1, Philadelphia declared a public health emergency regarding rapid increases in new acute hepatitis A virus (HAV) cases, with 355 locally-acquired cases…