Articles tagged "Liver cirrhosis"

2021 American Transplant Congress
Transplant-free Survival in Alcohol-related Liver Disease (ALD) Patients Presenting with First Evidence of Ascites
K. Fahoum¹, N. T. Shen², E. Basu¹, J. Lee³, A. Kaplan², A. Salajegheh⁴, R. Rosenblatt², A. Jesudian², C. Lucero², B. Fortune², M. M. Safford⁵, R. S. Brown²
¹Medical College, Weill Cornell Medicine, New York, NY, ²Gastroenterology and Hepatology, Weill Cornell Medicine, New York, NY, ³Population Health Sciences, Weill Cornell Medicine, New York, NY, ⁴Psychiatry, Weill Cornell Medicine, New York, NY, ⁵General Internal Medicine, Weill Cornell Medicine, New York, NY
*Purpose: The development of ascites is a poor prognostic sign for patients with cirrhosis. The factors associated with transplant-free survival at initial presentation with ascites…
2021 American Transplant Congress
Identification of Molecular Markers for Liver Cirrhosis by Single-nucleus Rna Sequencing
C. Kuscu¹, C. Kuscu¹, M. Akram², A. Shetty³, D. G. Maluf⁴, J. Eason¹, V. Mas⁵
¹Surgery, James D Eason Transplat Institute, Memphis, TN, ²Surgery, Center for Biomedical Informatics, Memphis, TN, ³Surgery, Institute for Genome Sciences, School of Medicine, Baltimore, MD, ⁴Surgery, Program in Transplantation University of Maryland, Baltimore, MD, ⁵Surgery, Division of Surgical Science University of Maryland, Baltimore, MD
*Purpose: Non-alcoholic fatty liver disease (NAFLD) is characterized by metabolic syndrome and the accumulation of fat in the liver cells (hepatocytes) leading to inflammation and…
2021 American Transplant Congress
Algorithms to Identify Alcoholic Hepatitis Hospitalizations in Patients with Cirrhosis
S. Panchal¹, D. Kaplan², D. Goldberg³, N. Mahmud²
¹Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, ²Gastroenterology, Hospital of the University of Pennsylvania, Philadelphia, PA, ³Gastroenterology, University of Miami Miller School of Medicine, Miami, FL
*Purpose: With the rising proportion of patients receiving liver transplantation for alcoholic hepatitis, it is important to identify methods of ascertaining hospitalizations with alcoholic hepatitis…
2021 American Transplant Congress
Longitudinal Quality of Life Assessment in Liver Transplant – Feasibility Study and Early Results
O. M. Siddiqui, P. Polineni, A. J. Thuluvath, C. Loftus
Northwestern University, Chicago, IL
*Purpose: In addition to survival, quality of life (QoL) is critical to optimizing care in liver transplantation (LT). Although QoL is associated with clinical outcomes…
2021 American Transplant Congress
A Shift in Paradigm: Phosphatidylethanol Testing to Monitor for and Address Alcohol Recidivism Following Liver Transplantation
F. M. Nimri¹, S. Naffouj¹, F. Askar¹, A. Singh², H. Gonzalez², S. Jafri²
¹Internal Medicine, Henry Ford Hospital, Detroit, MI, ²Gastroenterology, Henry Ford Hospital, Detroit, MI
*Purpose: Phosphatidylethanol (PEth) is a phospholipid that forms in the presence of ethanol with a long half-life compared to other alcohol detection tests. PEth testing…
2021 American Transplant Congress
The Rate of Hospitalization Among Patients with Cirrhosis is More Than Twice as High as Patients Over 85 Years
N. R. Mazumder¹, K. Guo², L. Zhao³, A. Kho¹, K. Walters⁴, T. S. Carey⁴, C. Loftus¹, D. P. Ladner¹
¹Northwestern Memorial Hospital, Chicago, IL, ²Biostatistics, Northwestern Memorial Hospital, Chicago, IL, ³Biostatistcs, Northwestern Memorial Hospital, Chicago, IL, ⁴University of North Carolina Chapel Hill, Chapel Hill, NC
*Purpose: Cirrhosis is a common disease however it is understudied because population data on patients with cirrhosis is lacking. While the risk of hospitalization in…
2021 American Transplant Congress
The Role of Histone Acetylation/methylation Mediated Epigenetic Modifications in the Pathogenesis of Non-alcoholic Steatohepatitis-associated Liver Carcinogenesis
P. K. Rajan¹, U. Utibe-Abasi¹, J. D. Sanabria¹, M. Banerjee², G. Smith¹, M. S. Schade¹, J. Sanabria¹, K. Sodhi¹, S. Pierre², Z. Xie², J. I. Shapiro², J. Sanabria¹
¹Department of Surgery, Marshall University, Huntington, WV, ²Marshall Institute for Interdisciplinary Research (MIIR), Marshall University, Huntington, WV
*Purpose: Hepatocellular carcinoma (HCC) is one of the most aggressive human cancers and is characterized by an acquisition of multiple abnormal phenotypes driven by epigenetic…
2021 American Transplant Congress
Outcomes of Transjugular Intrahepatic Portosystemic Shunts (TIPS) in Dialysis-Dependent ESLD Patients: The ALTA Study
J. Ge¹, J. Boike², M. German³, G. J. Morelli⁴, E. Spengler³, A. Said³, A. S. Lee³, A. Hristov³, A. Desai⁵, T. Couri⁶, S. Paul⁶, C. Frenette⁷, N. Christian-Miller⁷, M. Laurito⁸, E. Verna⁸, U. Rahim⁹, A. Goel⁹, D. Gregory², L. VanWagner², K. P. Kolli¹, J. Lai¹
¹University of California, San Francisco, San Francisco, CA, ²Northwestern Memorial Hospital, Chicago, IL, ³University of Wisconsin, Madison, WI, ⁴University of Florida Health, Gainsville, FL, ⁵Indiana University School of Medicine, Indianapolis, IN, ⁶University of Chicago, Chicago, IL, ⁷The Scripps Clinic, La Jolla, CA, ⁸Columbia University, New York, NY, ⁹Stanford University, Stanford, CA
*Purpose: Data on the outcomes of patients with cirrhosis who require renal replacement therapy (RRT) at the time of transjugular intrahepatic portosystemic shunts (TIPS) is…
2021 American Transplant Congress
Home-based Liver Frailty Intervention (lift) in Liver Transplant Candidates: A Pilot Study
A. J. Thuluvath¹, K. Belfanti¹, S. Morrissey¹, O. Siddiqui¹, J. Peipert¹, A. Daud¹, J. Levitsky¹, T. Bogg², A. Flores¹, D. P. Ladner¹
¹Northwestern University Transplant Research Collaborative, Chicago, IL, ²Department of Psychology, Wayne State University, Detroit, MI
*Purpose: Frailty is highly prevalent in patients awaiting LT and is associated with increased waitlist and post-transplant mortality, hospitalizations and LOS. While reduction of frailty…
2020 American Transplant Congress
Risk Prediction in the Meld-NA Era: The Tremendous Impact of Liver Related Complications
N. R. Mazumder¹, K. Atiemo², K. Jackson³, A. Daud⁴, A. Kho³, J. Levitsky¹, D. P. Ladner⁴
¹Gastroenterology and Hepatology, Northwestern University, Chicago, IL, ²Transplant Surgery, Tulane, New Orleans, LA, ³Center for Health Information Partnerships, Institute for Public Health and Medicine, Northwestern University, Chicago, IL, ⁴Transplant Surgery, Northwestern University, Chicago, IL
*Purpose: The MELD-Na score widely used for medical decision making but is not a good predictor of patient outcomes at low scores. Although portal hypertensive…