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Articles tagged "Liver cirrhosis"

  • 2016 American Transplant Congress

    Transcatheter Aortic Valve Replacement (TAVR) for Severe Aortic Stenosis as a Bridge to Liver Transplantation.

    R. Syed, P. Cox-Alomar, H. Bohorquez, G. Therapondos, N. Girgrah, S. Joshi, G. Tyson, T. Reichman, I. Carmody, G. Loss, A. Cohen, D. Bruce, E. Ahmed, J. Seal, P. Parrino, S. Ramee, N. Bzowej.

    Ochsner Medical Center, New Orleans, LA.

    Background: Historically, severe symptomatic aortic stenosis (AS) has been corrected surgically with aortic valve replacement. In patients with end stage liver disease (ESLD), cardiac surgery…
  • 2016 American Transplant Congress

    The Therapeutic Potential of Human Liver-Derived Stem Cell Transplantation in a Cirrhotic Liver Rat Model.

    S. Lee,1 J.-H. Lee,2 H.-J. Park,2 Y.-A. Kim,2 M.-N. Park,2 S.-K. Lee.1

    1Department of Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea; 2Stem Cell and Regenerative Medicine Center, Samsung Medical Center, Seoul, Republic of Korea.

    Cirrhosis is a long-term consequence of chronic hepatic injury and there are no effective treatment methods. Previous studies suggested that MSCs may ameliorate fibrogenesis through…
  • 2016 American Transplant Congress

    Is SVR Associated with Improved Hepatic Function in Hepatitis C Gen 1 Pts with Cirrhosis 1 Year After Completing Treatment with Sofosbuvir + Simeprevir +/- Ribavirin?

    A. Modi,1 J. Hermann,1 H. Nazario,2 S. Gonzalez,1 J. Gripshover,3 M. Gautam,1 J. Weinstein,2 D. Potosky,3 M. Barnes,2 A. Habib,2 P. Mantry,2 J. Trotter.1

    1Liver Consultants of Texas, Dallas-Fort Worth, TX; 2Liver Institute Methodist, Dallas, TX; 3University of Maryland, Baltimore, MD.

    Background: Combination antiviral therapy involving Sofosbuvir (SOF) & Simeprevir (SIM) +/- Ribavirin (RBV) is a relatively safe & effective Tx option in pts with gen…
  • 2015 American Transplant Congress

    Unrecognized Synchronous Hepatocellcular Carcinoma Lesions in Explanted Liver Transplant Specimens

    D. Aufhauser, Jr.,1 K. Eddinger,1 E. Furth,2 P. Abt,1 M. Levine.1

    1Department of Surgery, University of Pennsylvania, Philadelphia, PA; 2Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA.

    Introduction: Liver resection for early-stage hepatocellular carcinoma (HCC) is limited by high surgical risk in cirrhotics and high rates of intrahepatic recurrence. We postulated that…
  • 2015 American Transplant Congress

    Estimation of Glomerular Filtration Rate With Serum Cystatin C Accurately Discriminates Renal Dysfunction in Liver Transplant Candidates With End-Stage Liver Disease

    S. Gonzalez,1 J. Trotter,1 H. Szerlip,2 M. Levy,3 A. Chandrakantan,4 A. Yango,4 A. Rajagopal,4 Y. Barri,4 K. Rice,4 M. Saim,2 L. Melton,4 M. Emmett,2 G. Klintmalm,3 B. Fischbach.4

    1Hepatology, Baylor Simmons Transplant Institute, Fort Worth, TX; 2Nephrology, Baylor University Medical Center, Dallas, TX; 3Transplant Surgery, Baylor Simmons Transplant Institute, Fort Worth, TX; 4Nephrology, Baylor Simmons Transplant Institute, Fort Worth, TX.

    Background: Renal insufficiency is common in end-stage liver disease (ESLD) and is linked to survival in patients awaiting liver transplantation. Serum creatinine correlates poorly with…
  • 2015 American Transplant Congress

    MELD Velocity – An Early Predictor of Increased Mortality Risk

    D. Ladner,1 K. Skibba,2 J. Kang,1 B. Ho,1 A. Kho,1 L. Kulik,1 A. Daud,1 M. Abecassis,1 A. Skaro.1

    1Northwestern University, Chicago, IL; 2Rosalind Franklin University of Medicine and Science, Chicago, IL.

    INTRODUCTION: MELD is a satisfactory predictor of 3-month mortality in patients with cirrhosis. However, sub-populations of patients at increased hazard of mortality, but not well…
  • 2015 American Transplant Congress

    Functional Decline in Liver Transplant Candidates: Results from the Functional Assessment in Liver Transplantation (FrAILT) Study

    J. Lai, K. Covinsky, J. Dodge, S. Sen, S. Feng.

    UCSF, San Francisco, CA.

    Background: Cirrhosis is characterized by sarcopenia and malnutrition, leading to progressive functional decline. No studies have objectively measured physical functional decline in cirrhotics awaiting liver…
  • 2015 American Transplant Congress

    Pre-Transplant Portal Vein Recanalization-Transjugular Intrahepatic Portosystemic Shunt in Patients With Chronic Portal Vein Thrombosis

    B. Thornburg, K. Desai, T. Baker, J. Fryer, M. Abecassis, J. Caicedo, L. Kulik, R. Salem.

    Northwestern Memorial Hospital, Chicago, IL.

    Background: Chronic, occlusive portal vein thrombosis (PVT) associated with cirrhosis represents a relative contraindication to liver transplantation (LT) in some centers. From a surgical perspective,…
  • 2015 American Transplant Congress

    High Tolerability With Sofosbuvir-Based Direct-Acting Antiviral Therapy in Liver Transplant Recipients With Recurrent Hepatitis C

    B. Osborne,1 A. Modi,1 M. Gautam,1 N. Murray,1 I. Gonzalez,2 J. McAfee,2 S. Gonzalez.1

    1Hepatology, Baylor Simmons Transplant Institute, Fort Worth, TX; 2Hepatology, Liver Consultants of Texas, Fort Worth, TX.

    Background: Reports on efficacy, safety, and tolerability of sofobuvir-based antiviral regimens in liver transplant recipients with recurrent hepatitis C are limited. Methods: We performed a…
  • 2015 American Transplant Congress

    Hospital Characteristics Mediate Variation in Cirrhosis Mortality in Transplant and Non-Transplant Facilities

    A. Mathur,1 A. Chakrabarti,2 K. Sheetz,2 J. Mellinger,3 M. Volk,3 N. Katariya,1 A. Singer,1 W. Hewitt,1 K. Reddy,1 A. Moss.1

    1Surgery, Mayo Clinic Arizona, Phoenix, AZ; 2Surgery, University of Michigan, Ann Arbor, MI; 3Medicine, University of Michigan, Ann Arbor, MI.

    Hospitals vary significantly in cirrhosis mortality. We aimed to determine whether hospital structural characteristics mediate this effect.Methods: We used 2009 data from the HCUP Nationwide…
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