ATC Abstracts

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Articles tagged "Lipids"

  • 2016 American Transplant Congress

    Ex-Vivo Normothermic Perfusion (EVNP) Attenuation of Kidney Ischemia-Reperfusion Injury (IRI): A Proposed Mechanism.

    I. Palma,1 S. Kabagambe,1 Y. Smolin,1 T. Boyer,1 I. Palma,1 O. Fiehn,2 Y.-J. Chen,1 J. Sageshima,1 C. Santhanakrishnan,1 C. Troppmann,1 R. Perez.1

    1Department of Surgery, University of California, Davis Medical Center, Sacramento, CA; 2Department of Molecular and Cellular Biology & Genome Center, University of California-Davis, Davis, CA.

    Introduction: EVNP has the potential to repair deceased donor renal IRI. We hypothesize that EVNP may attenuate renal IRI via alteration of lipid metabolism.Methods: Eight…
  • 2016 American Transplant Congress

    Influence of Lipid Levels on Cardiovascular Events After Early Conversion from Calcineurin Inhibitor to Everolimus: 24 M Analysis of the ELEVATE Study.

    M. van der Giet,1 J. de Fijter,1 F. Oppenheimer,1 L. Toselli,1 G. Russ,1 P. Lopez,2 J. Aguilar,2 P. Bernhardt,2 Z. Wang,3 J. Cruzado,1 H. Holdaas.1

    1ELEVATE study group, Berlin, Germany; 2Novartis pharma AG, Basel, Switzerland; 3Novartis Pharmaceutical Corporation, East Hanover, NJ.

    Background: Immunosuppressive therapies are probably the most important cause of hyperlipidemia post-renal transplantation (RTx). Lipid abnormalities represent important biomarkers for cardiovascular (CV) risk. Here, we…
  • 2016 American Transplant Congress

    Sphingosine 1-Phosphate (S1P) Receptors Differentially Regulate Murine and Human CD4 T Cell Migration Across Lymphatic Endothelium.

    Y. Xiong,1 C. Brinkman,1 K. Hippen,2 B. Blazar,2 J. Bromberg.1

    1University of Maryland, Baltimore; 2University of Minnesota, Minneapolis.

    S1P and S1PR1 are used by T cells to migrate from thymus across microvascular endothelium to the blood circulation, and across medullary lymphatic endothelium of…
  • 2015 American Transplant Congress

    ABCB1 Haplotypes, Sex, Calcineurin Inhibitors and Lipid Profiles Post-Renal Transplant

    C. Meaney,1,2 R. Venuto,3 D. Brazeau,4 J. Consiglio,5 L. Cooper,1 G. Wilding,5 K. Tornatore.1,2,3

    1NYS Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY; 2School of Pharmacy, Buffalo, NY; 3Medicine, School of Medicine, Buffalo, NY; 4University of New England College of Pharmacy, Portland, ME; 5Biostatistics, School of Public Health, University at Buffalo, Buffalo, NY.

    Purpose: Hyperlipidemia is common in renal transplant recipients (RTR) during calcineurin inhibitor (CNI) immunosuppression. P-glycoprotein (P-gp) is an efflux transporter encoded by ABCB1 that modulates…
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