ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Leukocytes"

  • 2020 American Transplant Congress

    Early Impact of Interleukin-6 Blockade on the Distribution of Peripheral Blood Immune Cell Subpopulations – 3-Month Results of a Phase 2 Trial Evaluating Clazakizumab in Late Antibody-Mediated Rejection

    K. A. Doberer1, G. A. Boehmig1, M. Streitz2, S. Schlickeiser2, F. Bauernfeind1, A. Spittler3, B. Jilma4, F. Eskandary1, E. Chong5, S. Schranz4, K. Budde6, M. Dürr6

    1Department of Medicine III, Medical University of Vienna, Vienna, Austria, 2Charité Universitätsmedizin Berlin, Institute of Medical Immunology, Berlin, Germany, 3Center of Translational Research, Medical University of Vienna, Vienna, Austria, 4Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria, 5Vitaeris Inc., Vancouver, BC, Canada, 6Division of Nephrology and Intensive Care, Charité Universitätsmedizin Berlin, Berlin, Germany

    *Purpose: Interleukin-6 (IL-6) is considered to play a critical role within the multifacted pathophysiological process of antibody-mediated rejection (ABMR), including modulation of regulatory T cells…
  • 2020 American Transplant Congress

    Immune Cell Subset Profiles in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts) Desensitized with Clazakizumab (CLZ, Humanized Anti-IL-6 Monoclonal Antibody) Followed by Transplantation (Tx)

    S. Ge1, M. Chu1, A. D. Guzman1, E. D. Ortiz1, A. Vo2, N. Ammerman2, S. C. Jordan2, M. Toyoda1

    1Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, 2Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: IL-6, B cell growth factor, increases follicular T helper cell (Tfh) activity, promoting plasmablast (PB) and plasma cell (PC) differentiation, and antibody production. A…
  • 2020 American Transplant Congress

    Pre- And Post-Transplant (Tx) Clazakizumab (CLZ, Humanized Anti-IL-6 Monoclonal Antibody) Treatment Increased Regulatory T Cell (Treg) Percentage in CD4+ T Cells in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts)

    S. Ge1, M. Chu1, E. D. Ortiz1, A. D. Guzman1, A. Vo2, N. Ammerman2, S. C. Jordan2, M. Toyoda1

    1Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, 2Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: IL-6 is a B cell growth factor and pro-inflammatory cytokine. Inhibition of IL-6 signaling modulates B cell activation and inflammatory process possibly through Treg…
  • 2020 American Transplant Congress

    Mechanisms by Which Donor Bone-Marrow CXCR4+ Foxp3+ Tregs Promote Long-Term Survival of Murine Limb Allografts

    L. Wang1, Z. Wang2, R. Han1, A. Samanta1, G. Ge1, L. S. Levin1, M. H. Levine1, W. W. Hancock3

    1Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA, 3Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA

    *Purpose: Vascularized composite allotransplantation (VCA) allows tissue replacement after devastating loss but is currently limited in application and may be more widely performed if maintenance…
  • 2020 American Transplant Congress

    Filgrastim Utilization Evaluation in Solid Organ Transplant Recipients

    O. Witkowsky, L. Stanz, K. Schnelle

    The Ohio State University Wexner Medical Center, Columbus, OH

    *Purpose: Neutropenia occurs in up to 40% of kidney and liver transplant (txp) recipients and has been associated with higher mortality rates in liver txp.…
  • 2020 American Transplant Congress

    Recipient Myeloid Cell Myeloperoxidase is Required for Nk Cell Activation During Antibody-Mediated Allograft Rejection

    S. Miyairi, N. Dvorina, K. S. Keslar, A. Valujskikh, W. M. Baldwin, R. L. Fairchild

    Immunology, Cleveland Clinic Lerner Research Institute, Cleveland, OH

    *Purpose: Dysregulated donor-specific antibody (DSA) responses are induced in B6.CCR5-/- mice transplanted with complete MHC mismatched A/J kidney allografts and are required for rejection of…
  • 2020 American Transplant Congress

    Neuropilin 2 is a Novel Coinhibitory Molecule That Suppresses Alloimmune Responses Following Transplantation

    J. Wedel, J. Lee, N. Kochupurakkal, E. Chernov, M. Poreddy, K. Liu, S. Kong, D. Bielenberg, H. Nakayama, D. M. Briscoe

    Boston Children's Hospital, Boston, MA

    *Purpose: We have previously reported that signaling via the transmembrane receptor neuropilin 2 (NRP2) regulates PI3K/mTOR/Akt activity in several human cell lines. Furthermore, it is…
  • 2020 American Transplant Congress

    Outcomes in Liver Transplantation with Use of Granulocyte-Colony Stimulating Factor

    K. Schnelle, A. Leino, M. Chunduru, L. Von Stein, O. Witkowsky

    The Ohio State Wexner Medical Center, Columbus, OH

    *Purpose: Questions remain if treatment with a granulocyte-colony stimulating factor (G-CSF) impacts clinical outcomes after liver transplant. The purpose of this study was to compare…
  • 2020 American Transplant Congress

    IL-33 is a Potent Injury Signal That Programs Graft Macrophage Metabolism Toward That Required for Reparative and Regulatory Functions

    T. Li1, Z. Zhang1, Q. Liu1, J. Bartolacci2, M. Velayutham1, G. Hussey2, J. Dziki2, L. Mathews1, Y. Lee3, G. Dwyer1, H. Dai1, A. Roessing1, S. Shiva4, M. Oberbarnscheidt1, S. Badylak2, H. Turnquist1

    1Starzl Transplant Inst. and Dept. Surgery, University of Pittsburgh, Pittsburgh, PA, 2McGowan Inst. and Dept. of Surgery, University of Pittsburgh, Pittsburgh, PA, 3Bioengineering, University of Pittsburgh, Pittsburgh, PA, 4Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA

    *Purpose: Sequestered self-molecules, such as HMGB1 or haptoglobin, are appreciated to stimulate the pro-inflammatory response of infiltrating innate immune cells by targeting TLR4 after their…
  • 2020 American Transplant Congress

    Sialoadhesin Mediates the Adhesion of Human RBC to Porcine Macrophages from Genetically Engineered Pigs

    K. Petitpas1, B. Cerel1, Z. Abady1, L. Burdorf1, D. L. Ayares2, D. M. Magnani3, R. N. Pierson III1, A. M. Azimzadeh1

    1Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, 2Revivicor, Blacksburg, VA, 3MassBiologics of UMMS, Boston, MA

    *Purpose: The sequestration of human RBC is prominent after liver and lung xenotransplantation. Rees et al previously implicated porcine sialoadhesin in adhesion of human RBC…
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