Articles tagged "Leukocytes"

2022 American Transplant Congress
Utility of Cytomegalovirus T-Cell Immunity Panel to Predict CMV Infections in Lung Transplant Recipients
R. W. Lincoln¹, B. J. Pierce¹, C. Pham¹, S. W. Yau², A. Goodarzi², J. G. Youssef², H. J. Huang²
¹Pharmacy, Houston Methodist Hospital, Houston, TX, ²Pulmonology, Houston Methodist Hospital, Houston, TX
*Purpose: Given the limited data of cytomegalovirus T-cell immunity panels (CMV TCIP) in lung transplant recipients (LTR), we sought to describe our center’s experience with…
2022 American Transplant Congress
P2X7R Inhibition Impairs In Vitro Training of Macrophages
H. H. Lancia¹, R. Sanchez², A. G. Lellouch¹, C. L. Cetrulo¹, J. Ochando³, G. Benichou⁴
¹Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ²Icahn School of Medicine at Mount Sinai, New York, NY, ³Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, ⁴Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA
*Purpose: Macrophage training and ATP-mediated P2X7R signaling are unrelated key elements of the innate immune response associated with allotransplant rejection. In the present study, we…
2022 American Transplant Congress
Single Cell RNAseq Analysis of Human Renal Allograft Rejection Demonstrates Distinct Transcriptomic Profiles That Vary Based on the Type of Maintenance Immunosuppression
T. Shi¹, A. Burg¹, K. Roskin², J. Rush³, B. Haraldsson³, A. Shields⁴, R. Alloway⁴, E. Woodle⁵, D. Hildeman¹
¹Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Novartis Pharmaceuticals AG, Basel, Switzerland, ⁴Internal Medicine, University of Cincinnati, Cincinnati, OH, ⁵Surgery, University of Cincinnati, Cincinnati, OH
*Purpose: Rejection therapy has remained unchanged for 60 years and is associated with significant failure and infection rates. Development of new anti-rejection therapies requires mechanistic…
2022 American Transplant Congress
Apheresis of Deceased Donors: A New Source of Mobilized Peripheral Blood Hematopoietic Stem Cells for Transplant Tolerance
R. A. Sosa¹, T. Mone², B. V. Naini¹, D. B. Kohn³, E. F. Reed¹, K. Wheeler², B. Campo-Fernandez³, A. Davila³, D. J. Chaffin⁴, J. DiNorcia⁵, F. M. Kaldas⁵, A. Cohen², E. Lum⁶, J. L. Veale⁷, N. M. Kogut⁷
¹Pathology and Lab Medicine, UCLA, Los Angeles, CA, ²One Legacy, Los Angeles, CA, ³Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, ⁴LifeStream Blood Bank, San Bernadino, CA, ⁵Surgery, UCLA, Los Angeles, CA, ⁶Medicine, UCLA, Los Angeles, CA, ⁷Urology, UCLA, Los Angeles, CA
*Purpose: Solid organ transplantation is the therapy of choice for many patients with end-stage organ failure, but recipients must remain on lifelong immune suppression, leaving…
2022 American Transplant Congress
P2X7R Signaling Controls Exosome Release by Macrophages and Donor MHC Cross-Dressing After Skin Transplantation
H. H. Lancia¹, N. Carnel², A. G. Lellouch¹, C. Cetrulo¹, G. Benichou²
¹Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ²Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA
*Purpose: Exosomes released by transplanted organs play an important role in the host's immune response leading to their rejection. Donor exosomes contribute to alloimmunity by…
2021 American Transplant Congress
Leukopenia in the Renal Transplant Population
A. Johnson¹, G. Karadkhele², C. Larsen¹
¹Emory University, Atlanta, GA, ²Surgery, Emory University, Atlanta, GA
*Purpose: Leukopenia is a common complication for transplant patients on immunosuppression, but etiologies, timing, and outcomes are only superficially understood.*Methods: All patients undergoing kidney transplant…
2020 American Transplant Congress
Early Impact of Interleukin-6 Blockade on the Distribution of Peripheral Blood Immune Cell Subpopulations – 3-Month Results of a Phase 2 Trial Evaluating Clazakizumab in Late Antibody-Mediated Rejection
K. A. Doberer¹, G. A. Boehmig¹, M. Streitz², S. Schlickeiser², F. Bauernfeind¹, A. Spittler³, B. Jilma⁴, F. Eskandary¹, E. Chong⁵, S. Schranz⁴, K. Budde⁶, M. Dürr⁶
¹Department of Medicine III, Medical University of Vienna, Vienna, Austria, ²Charité Universitätsmedizin Berlin, Institute of Medical Immunology, Berlin, Germany, ³Center of Translational Research, Medical University of Vienna, Vienna, Austria, ⁴Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria, ⁵Vitaeris Inc., Vancouver, BC, Canada, ⁶Division of Nephrology and Intensive Care, Charité Universitätsmedizin Berlin, Berlin, Germany
*Purpose: Interleukin-6 (IL-6) is considered to play a critical role within the multifacted pathophysiological process of antibody-mediated rejection (ABMR), including modulation of regulatory T cells…
2020 American Transplant Congress
Immune Cell Subset Profiles in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts) Desensitized with Clazakizumab (CLZ, Humanized Anti-IL-6 Monoclonal Antibody) Followed by Transplantation (Tx)
S. Ge¹, M. Chu¹, A. D. Guzman¹, E. D. Ortiz¹, A. Vo², N. Ammerman², S. C. Jordan², M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: IL-6, B cell growth factor, increases follicular T helper cell (Tfh) activity, promoting plasmablast (PB) and plasma cell (PC) differentiation, and antibody production. A…
2020 American Transplant Congress
Pre- And Post-Transplant (Tx) Clazakizumab (CLZ, Humanized Anti-IL-6 Monoclonal Antibody) Treatment Increased Regulatory T Cell (Treg) Percentage in CD4+ T Cells in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts)
S. Ge¹, M. Chu¹, E. D. Ortiz¹, A. D. Guzman¹, A. Vo², N. Ammerman², S. C. Jordan², M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: IL-6 is a B cell growth factor and pro-inflammatory cytokine. Inhibition of IL-6 signaling modulates B cell activation and inflammatory process possibly through Treg…
2020 American Transplant Congress
Mechanisms by Which Donor Bone-Marrow CXCR4+ Foxp3+ Tregs Promote Long-Term Survival of Murine Limb Allografts
L. Wang¹, Z. Wang², R. Han¹, A. Samanta¹, G. Ge¹, L. S. Levin¹, M. H. Levine¹, W. W. Hancock³
¹Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA
*Purpose: Vascularized composite allotransplantation (VCA) allows tissue replacement after devastating loss but is currently limited in application and may be more widely performed if maintenance…

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