ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "knockout"

  • 2015 American Transplant Congress

    Leukocyte Associated Immunoglobulin-Like Receptor 1 inhibits Th1 But Enhances Th17 Responses

    V. Agashe,1 M. Keller,2 L. Haynes,1 E. Jankowska-Gan,1 J. Sullivan,1 J. Kernien,1 H. Suzuki,3 D. Wilkes,4 W. Burlingham.1

    1Surgery, UW Madison, Madison, WI; 2Tulane University, New Orleans, LA; 3Chiba Graduate School of Medicine, Chiba, Japan; 4Indiana University School of Medicine, Indianapolis, IN.

    Background: Leukocyte Associated Immunoglobulin-like Receptor 1 (LAIR1), is a transmembrane receptor expressed by immune cells. It recognizes collagen repeats via its extracellular domain and has…
  • 2015 American Transplant Congress

    Eomes-Expressing CD8+ T Cells and Th17 Cells Mediate Costimulatory Blockade-Resistant Allograft Rejection in Mice

    M. Sabet-Baktach,1 E. Eggenhofer,1 P. Renner,1 M. Lantow,1 H. Schlitt,1 E. Geissler,1 A. Kroemer.1,2

    1Department of Surgery, University Hospital Regensburg, Regensburg, Germany; 2Georgetown Transplant Institute, Georgetown Transplant Institute, Washington, DC.

    The etiology of costimulatory blockade-resistant allograft rejection remains unclear. Therefore, the purpose of this study was to evaluate the responsiveness of distinct CD4+ and CD8+…
  • 2015 American Transplant Congress

    miRNA-181 Promotes Graft Prolongation by Plasmacytoid Dendritic Cells By Increasing T Regulatory Cells and Decreasing B Cells as Revealed By Cytometry By Time-Of-Flight

    A. Lau,1,2 M. Vitalone,1 X. Qu,1 T. Shawler,1 O. Martinez,1 C. Esquivel,1 S. Krams.1

    1Surgery, Stanford University, Stanford, CA; 2Pediatrics, UCSF, San Francisco, CA.

    Liver allografts are well tolerated and other solid organ allografts, when transplanted concurrently with livers, show improved outcomes. However, the mechanisms underlying “hepatic tolerance” have…
  • 2015 American Transplant Congress

    Blocking CD40/CD154 Co-Stimulation Prevents Acute Antibody-Mediated Renal Allograft Rejection Induced by Memory CD4 T Cells

    V. Gorbacheva, R. Fan, A. Valujskikh.

    Immunology, The Cleveland Clinic, Cleveland, OH.

    Immunosuppression-resistant alloreactive memory CD4 T cells induce robust responses against organ transplants. In murine heart allograft recipients donor-reactive memory CD4 T cells provide help for…
  • 2015 American Transplant Congress

    Donor CD47 Plays a Critical Role in the Control of Alloreactive T Cell Activation Following Hepatocyte Transplantation

    M. Zhang,1,2 H. Wang,1 N. Navarro-Alvarez,1 Y. Zheng,2 Y.-G. Yang.1

    1Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY; 2First Hospital, Jilin University, Changchun, Jilin, China.

    Background: The interspecies incompatibility of CD47 is an important mechanism triggering rejection of cellular xenografts, including both hematopoietic and non-hematopoietic cells, by recipient macrophages. Our…
  • 2015 American Transplant Congress

    Myeloid Cell-Specific Heme Oxygenase-1 Is Crucial for Hepatoprotection in Liver Ischemia-Reperfusion Injury

    K. Nakamura,1 M. Zhang,2 B. Ke,1 R. Busuttil,1 J. Araujo,2 J. Kupiec-Weglinski.1

    1Surgery, Liver Transplant, University of California, Los Angeles, Los Angeles, CA; 2Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA.

    Background and Aim: Heme oxygenase-1 (HO-1), an anti-oxidant enzyme, is essential in tissue resistance against innate immunity driven ischemia-reperfusion injury (IRI). Our group was the…
  • 2015 American Transplant Congress

    Damage Associated Molecular Patterns (DAMPs)-Activated Neutrophil Extracellular Trap Formation Exacerbates Liver Ischemia/Reperfusion Injury

    H. Huang, S. Tohme, A. Al-Khafaji, A. Tsung.

    Department of Surgery, University of Pittsburgh, Pittsburgh, PA.

    Liver ischemia/reperfusion (I/R) injury is a clinically important phenomenon encountered during transplantation that contributes to initial graft function and subsequent allograft rejection. Formation of neutrophil…
  • 2015 American Transplant Congress

    Interleukin-17 Deficiency Attenuates Renal Allograft Injury and Prolongs Survival in a Murine Transplantation Model

    T. Kwan,1,2 S. Chadban,1,2 J. Ma,1,2 S. Bao,2,3 S. Alexander,2,4 H. Wu.1,2

    1Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia; 2Renal Medicine, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia; 3Discipline of Pathology, School of Medical Sciences, Sydney, New South Wales, Australia; 4Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.

    Aim:To investigate the role of IL-17 in allograft rejection using a murine model of fully MHC-mismatched renal transplantation.Methods:Life-sustaining kidney transplants were performed in nephrectomized mice:…
  • 2015 American Transplant Congress

    Inflammasome Activation in Hepatocytes and Kupffer Cells Orchestrates the Hepatotoxic Effect of Bile Acids and Can Be Potential Target in the Management of Cholestatic Liver Injury

    X. Liu,1 T. Ma,1 T. Billiar,2 R. Tao.1

    1Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial Peoples' Hospital, Hangzhou, Zhejiang Province, China; 2Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.

    Purpose: Cholestatic liver injury (CLI) is commonly associated with many hepatobiliary diseases and substantially increases the peri-operative morbidity and mortality in liver surgery and transplantation.…
  • 2015 American Transplant Congress

    Macrophage-Specific SIRT1 Regulates HO-1 Mediated Anti-Inflammatory and Cytoprotective Pathways

    K. Nakamura,1 M. Zhang,2 B. Ke,1 R. Busuttil,1 J. Araujo,2 J. Kupiec-Weglinski.1

    1Surgery, Liver Transplant, University of California, Los Angeles, Los Angeles, CA; 2Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA.

    Background/Aim: Sirtuin1 (SIRT1), a NAD+-dependent type III histone/protein deacetylase, is essential for resistance against liver ischemia-reperfusion injury (IRI). We asked whether SIRT1 may affect cytoprotective…
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