ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "knockout"

  • 2016 American Transplant Congress

    Absence of Receptors for C3a or C5a Prevent Alloreactive CD8 T Effector Cell (Teff) Expansion but Differentially Impact Memory (Tmem) Persistence Posttransplantation.

    D. Mathern, P. Heeger.

    Translational Transplant Research Center, Dept of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

    As Tmem are known barriers to transplant survival and tolerance in animals and human transplant recipients, understanding factors that drive the formation and survival of…
  • 2016 American Transplant Congress

    Abrogating Donor-Derived Myd88 Signaling Impairs the Recruitment of Recipient Neutrophils and CD8 T Cells into Lung Allografts in Mice.

    Z. Zheng,1 J.-J. Wang,1 X. Yeap,1 X. Kang,1 Y. Xie,1 X. Luo,2 Z. Zhang.1

    1Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL; 2Division of Nephrology and Hypertension, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.

    Objectives: Transplant ischemia reperfusion injury (IRI) mediated primary graft dysfunction (PGD) remains the predominant cause of short- and long-term graft loss in lung transplantation. This…
  • 2016 American Transplant Congress

    TGFb in Regulatory B Cells-Dependent Tolerance.

    H. Deirawan, L. Kojima, L. Washburn, J. Markmann, J. Kim.

    Surgery, Massachusetts General Hospital, Boston, MA.

    In transplantation, increasing evidence support that B cells can play a major regulatory role in addition to their critical functions in allo-immunity and graft rejection.…
  • 2016 American Transplant Congress

    mTORC2 Negatively Regulates Dendritic Cell (DC) Metabolism and the Allostimulatory Function of Donor DCs in Organ Transplantation.

    A. Watson,1,2 D. Raïche-Regué,1 H. Dai,1 K. Fabian,3,4 G. Delgoffe,4,5 W. Storkus,3,4 A. Thomson.1,2

    1Starzl Transplantation Institute, Univ. of Pittsburgh, Pittsburgh, PA; 2Pathology, Univ. of Pittsburgh, Pittsburgh, PA; 3Dermatology, Univ. of Pittsburgh, Pittsburgh, PA; 4Immunology, Univ. of Pittsburgh, Pittsburgh, PA; 5Cancer Institute, Univ. of Pittsburgh, Pittsburgh, PA.

    The mechanistic target of rapamycin (mTOR) is a kinase that functions in at least two complexes: rapamycin (RAPA)-sensitive mTORC1 and RAPA-insensitive mTORC2. These complexes play…
  • 2016 American Transplant Congress

    Role of NRP1 in CD4+ T Cell Allo-Activation.

    E. Lee, H. Kim, G. Demirci.

    Department of Surgery, Boston Children's Hospital, Boston, MA.

    Introduction: Neuropilin-1 (NRP1) is a transmembrane glycoprotein that functions as a co-receptor for class III/IV semaphorins, VEGF, and several other growth factors. NRP1 has been…
  • 2016 American Transplant Congress

    Gsk3β Regulates Macrophage Pro-Inflammatory Immune Activation via AMPK-Mediated Induction of Small Heterodimer Partner (SHP).

    H. Zhou,1,2 J. Zhu,1,3 S. Yue,1 R. Busuttil,1 J. Kupiec-Weglinski,1 X. Wang,2 Y. Zhai.1

    1Surgery, David Geffen School of Medicine-University of California-Los Angeles, LA, CA; 2Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China; 3Liver Surgery, Renji Hospital, Shanghai, China.

    Background & AimsAlthough glycogen synthase kinase 3 β (Gsk3β) has been found to play key roles in ischemia and reperfusion injuries (IRI) of different organs,…
  • 2016 American Transplant Congress

    Macrophage Specific Deletion of RhoA Impedes Macrophage Functions and Abrogates Chronic Rejection of Cardiac Allograft.

    Y. Liu, W. Chen, X. Li, R. Ghobrial, M. Kloc.

    Surgery, The Houston Methodist, Houston, TX.

    Objective. Chronic rejection of transplanted organs remains the main obstacle in the long-term success of organ transplantation. Chronic rejection occurs in 40-45% of recipients at…
  • 2016 American Transplant Congress

    HO-1/SIRT1/p53 Axis Regulates Macrophage Activation and Attenuates Liver Ischemia-Reperfusion Injury in Mice.

    K. Nakamura,1 M. Zhang,2 B. Ke,1 S. Kageyama,1 R. Busuttil,1 J. Araujo,2 J. Kupiec-Weglinski.1

    1Surgery, Liver Transplant, University of California-Los Angeles, Los Angeles, CA; 2Medicine, Division of Cardiology, University of California-Los Angeles, Los Angeles, CA.

    Background/Aim: The mechanism by which macrophage heme oxygenase-1 (HO-1)-Sirtuin1 (SIRT1) signaling promotes resistance against inflammation response in liver ischemia-reperfusion injury (IRI) remains elusive. As tumor…
  • 2015 American Transplant Congress

    Leukocyte Associated Immunoglobulin-Like Receptor 1 inhibits Th1 But Enhances Th17 Responses

    V. Agashe,1 M. Keller,2 L. Haynes,1 E. Jankowska-Gan,1 J. Sullivan,1 J. Kernien,1 H. Suzuki,3 D. Wilkes,4 W. Burlingham.1

    1Surgery, UW Madison, Madison, WI; 2Tulane University, New Orleans, LA; 3Chiba Graduate School of Medicine, Chiba, Japan; 4Indiana University School of Medicine, Indianapolis, IN.

    Background: Leukocyte Associated Immunoglobulin-like Receptor 1 (LAIR1), is a transmembrane receptor expressed by immune cells. It recognizes collagen repeats via its extracellular domain and has…
  • 2015 American Transplant Congress

    Eomes-Expressing CD8+ T Cells and Th17 Cells Mediate Costimulatory Blockade-Resistant Allograft Rejection in Mice

    M. Sabet-Baktach,1 E. Eggenhofer,1 P. Renner,1 M. Lantow,1 H. Schlitt,1 E. Geissler,1 A. Kroemer.1,2

    1Department of Surgery, University Hospital Regensburg, Regensburg, Germany; 2Georgetown Transplant Institute, Georgetown Transplant Institute, Washington, DC.

    The etiology of costimulatory blockade-resistant allograft rejection remains unclear. Therefore, the purpose of this study was to evaluate the responsiveness of distinct CD4+ and CD8+…
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