Articles tagged "knockout"

2015 American Transplant Congress
Inflammasome Activation in Hepatocytes and Kupffer Cells Orchestrates the Hepatotoxic Effect of Bile Acids and Can Be Potential Target in the Management of Cholestatic Liver Injury
X. Liu,¹ T. Ma,¹ T. Billiar,² R. Tao.¹
¹Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial Peoples' Hospital, Hangzhou, Zhejiang Province, China; ²Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
Purpose: Cholestatic liver injury (CLI) is commonly associated with many hepatobiliary diseases and substantially increases the peri-operative morbidity and mortality in liver surgery and transplantation.…
2015 American Transplant Congress
Macrophage-Specific SIRT1 Regulates HO-1 Mediated Anti-Inflammatory and Cytoprotective Pathways
K. Nakamura,¹ M. Zhang,² B. Ke,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, University of California, Los Angeles, Los Angeles, CA; ²Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA.
Background/Aim: Sirtuin1 (SIRT1), a NAD+-dependent type III histone/protein deacetylase, is essential for resistance against liver ischemia-reperfusion injury (IRI). We asked whether SIRT1 may affect cytoprotective…
2015 American Transplant Congress
miR-155 Different Roles in UCB iTreg and nTreg
Y. Lu, L. Lu.
Liver Transplantation Center of First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
OBJECTIVES:miR-155 has been associated with both innate and adaptive immune responses. SOCS1, which is involved in Treg survival and function, is a direct target of…
2015 American Transplant Congress
Macrophage Specific β-Catenin Controls ROCK/PTEN Function and Regulates Innate Immunity in Liver Inflammation
S. Yue,¹ X. Zhou,² M. Zhou,¹ Y. Zhai,¹ R. Busuttil,¹ Q. Ying,² J. Kupiec-Weglinski,¹ B. Ke.¹
¹Dumont-UCLA Transplant Center, Dept. of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA; ²Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Dept. of Stem Cell Biology & Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Background: It has been shown that β-catenin is an important regulator of cell development, regeneration, and carcinogenesis. Our previous studies demonstrated the key role of…