ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "knockout"

  • 2018 American Transplant Congress

    Upregulated IL-33 in Heart Transplants Modulates Local Myeloid Populations to Protect against Chronic Allograft Rejection

    Z. Zhang,1 Q. Liu,1 G. Hussey,2 J. Dziki,2 L. Mathews,1 H. Dai,1 G. Dwyer,1,3 A. Lucas,1 M. Oberbarnscheidt,1 S. Badylak,2 H. Turnquist.1,3

    1University of Pittsburgh, Starzl Transplant Institute, Pittsburgh, PA; 2University of Pittsburgh, McGowan Institute for Regenerative Medicine, Pittsburgh, PA; 3Immunology, University of Pittsburgh, Pittsburgh, PA.

    Purpose: Interleukin-33 (IL-33) is an “alarmin”, or a self-derived molecule that triggers pleotropic immune responses after release from damaged tissue. Yet, how IL-33 shapes alloresponses…
  • 2018 American Transplant Congress

    Ablation of Both mTOR and STAT3 in T Cells Induces Heart Transplant Acceptance in Donor Skin-Sensitized Mice

    A. Xie,1,2 W. Chen.2,3

    1Division of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; 2Center for Immunobiology and Transplantation Research, Houston Methodist Research Institute, Houston, TX; 3Department of Surgery, Weill Cornell Medical College of Cornell University, New York, NY.

    Allogeneic memory T cell response precludes the induction of transplant acceptance; how this process is regulated at the molecular level remains unclear. Both mTOR and…
  • 2018 American Transplant Congress

    Lymph Node Stromal Laminins Affect Graft Survival through Regulation of CD4 T Cell Proliferation and Migration

    L. Li, T. Simon, W. Piao, Y. Xiong, V. Saxena, T. Zhang, C. Wagner, J. Bromberg.

    University of Maryland, Baltimore, MD.

    Background: Our prior studies demonstrated that tolerance and immunity are associated with differential expression of lymph node (LN) stromal laminins α4β1γ1 (411) and α5β1γ1 (511),…
  • 2018 American Transplant Congress

    Lymphotoxin Beta Receptor Modulation in Lymphatic Endothelial Cells Alters Regulatory T Cell Dynamics

    V. Saxena, W. Piao, Y. Xiong, L. Li, C. Wagner, J. Bromberg.

    U Maryland, Baltimore, MD.

    Background:Lymphotoxin beta receptor (LTβR) mediated signaling in lymphatic endothelium cells (LEC) is important for migration of regulatory T cells (Treg) to afferent lymphatic vessels (LV)…
  • 2018 American Transplant Congress

    Role of B Cell Intrinsic NLRP3 in the Development of Chronic Rejection

    J. Nie,1 B. Ramaswami,2 X. Guo,3 R. Hoffman,2 G. Chalasani.3

    1Thoracic Surgery, Huazhong University of Science and Technology, Wuhan, Hubei, China; 2Surgery, Starzl Transplantation Institute, Pittsburgh, PA; 3Medicine, University of Pittsburgh, Pittsburgh, PA.

    Endogenous DAMPs elicited during transplantation are recognized via TLR-MyD88 and NLRP3-inflammosome pathways that are expressed in APCs including B cells. Here, we asked whether B…
  • 2018 American Transplant Congress

    Recipient Conditioning Results in IL-33 Support of Potent Th1 Alloimmune Responses after CD4+ T Cells Upregulate ST2 during Lymphopenia Induced Proliferation

    G. Dwyer,1 L. Mathews,1 A. Lucas,1 B. Blazar,2 H. Turnquist.1

    1Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2Department of Pediatrics, University of Minnesota, Minneapolis, MN.

    Purpose: IL-33 is typically associated with support of Th2 and Treg responses. Yet, recipient conditioning before allogeneic hematopoietic cell transplantation (alloHCT) releases IL-33 to promote…
  • 2017 American Transplant Congress

    Abrogating MyD88 Signaling in Donor Lung Resident Hematopoietic Cells Promotes Cell Based Tolerance Induction in Lung Allografts in Mice.

    Z. Zheng,1 J. Wang,1 X. Yeap,1 L. Li,3 L. Zhang,2 M. He,1 X. Luo,2 Z. Zhang.1

    1Comprehensive Transplant Center and Department of Surgery, Chicago, IL; 2Division of Nephrology and Hypertension, Chicago, IL; 3Department of Pathology, Chicago, IL

    Objectives: MyD88 signaling plays an important role in allograft rejection and tolerance induction. This study is designed to determine the cellular base of MyD88 expression…
  • 2017 American Transplant Congress

    Deleting LAG-3 Accelerates Cardiac Allograft Rejection and Augments T Cell Memory in Mice.

    J. Erfe,1,2 C. Yang,1 D. Ndishabandi,1 I. Rosales,1 R. White,1 P. Russell,1 R. Colvin,1 J. Madsen,1 A. Alessandrini.1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; 2Yale School of Medicine, New Haven, CT

    Purpose: Lymphocyte Activation Gene-3 (LAG-3) expresses a transmembrane receptor on activated immune cells such as T cells, NK cells, and plasmacytoid dendritic cells. It is…
  • 2017 American Transplant Congress

    Recipient iNOS Deficiency Reduces Spontaneous Kidney Allograft Acceptance by Accelerating Allograft Loss.

    I. Aljabban, B. Jiang, C. Yang, D. Ndishabandi, R. White, P. Russell, J. Madsen, R. Colvin, A. Alessandrini.

    Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA

    Nitric oxide (NO) production by inducible nitric oxide synthase (iNOS), encoded by NOS2, is a hallmark of the innate immune axis, and is typically associated…
  • 2017 American Transplant Congress

    mTORC1 and 2 Regulate Dendritic Cell (DC) Metabolism and Allostimulatory Function of Donor DCs in Skin Transplantation.

    A. Watson,1,2 H. Dai,1,3 A. Menk,4,5 G. Delgoffe,4,5 A. Thomson.1,2,3

    1Starzl Transplantation Institute, Univ. of Pittsburgh, Pittsburgh; 2Pathology, Univ. of Pittsburgh, Pittsburgh; 3Surgery, Univ. of Pittsburgh, Pittsburgh; 4Immunology, Univ. of Pittsburgh, Pittsburgh; 5Cancer Institute, Univ. of Pittsburgh, Pittsburgh

    Background/Hypothesis: The mechanistic target of rapamycin (mTOR) is a kinase that functions in two complexes: rapamycin (RAPA)-sensitive mTORC1 and RAPA-insensitive mTORC2. These complexes play critical…
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