2017 American Transplant Congress
TIMP-3 Plays a Key Regulatory Role in the Cleavage of E-Cadherin and Has an Essential Protective Function in Hepatic IRI.
Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA
Liver ischemia-reperfusion injury (IRI) remains a challenging problem in clinical orthotopic liver transplantation. Tissue inhibitor of metalloproteinases-3 (TIMP-3), an extracellular matrix-associated protein, has been linked…2017 American Transplant Congress
Dendritic Cell Expression of Rictor (mTORC2), but Not Raptor (mTORC1), Protects Against Renal Ischemia-Reperfusion Injury.
Background: Dendritic cells (DC) are critical initiators of innate immunity in the kidney and orchestrate inflammation subsequent to ischemia-reperfusion injury (IRI). The mechanistic target of…2017 American Transplant Congress
Macrophage Specific Deletion of RhoA Inhibits Fractalkine Signaling and Abrogates Chronic Rejection of Cardiac Allograft.
Surgery, Houston Methodist Hospital and Research Institute, Houston
Objective. Chronic rejection of transplanted organs remains unresolved issue in organ transplantation. The chronic rejection is the most common cause of graft loss within 10…2017 American Transplant Congress
Abrogating MyD88 Signaling in Donor Lung Resident Hematopoietic Cells Promotes Cell Based Tolerance Induction in Lung Allografts in Mice.
Objectives: MyD88 signaling plays an important role in allograft rejection and tolerance induction. This study is designed to determine the cellular base of MyD88 expression…2017 American Transplant Congress
Deleting LAG-3 Accelerates Cardiac Allograft Rejection and Augments T Cell Memory in Mice.
Purpose: Lymphocyte Activation Gene-3 (LAG-3) expresses a transmembrane receptor on activated immune cells such as T cells, NK cells, and plasmacytoid dendritic cells. It is…2017 American Transplant Congress
Recipient iNOS Deficiency Reduces Spontaneous Kidney Allograft Acceptance by Accelerating Allograft Loss.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
Nitric oxide (NO) production by inducible nitric oxide synthase (iNOS), encoded by NOS2, is a hallmark of the innate immune axis, and is typically associated…2017 American Transplant Congress
mTORC1 and 2 Regulate Dendritic Cell (DC) Metabolism and Allostimulatory Function of Donor DCs in Skin Transplantation.
Background/Hypothesis: The mechanistic target of rapamycin (mTOR) is a kinase that functions in two complexes: rapamycin (RAPA)-sensitive mTORC1 and RAPA-insensitive mTORC2. These complexes play critical…2016 American Transplant Congress
mTORC2 Negatively Regulates Dendritic Cell (DC) Metabolism and the Allostimulatory Function of Donor DCs in Organ Transplantation.
The mechanistic target of rapamycin (mTOR) is a kinase that functions in at least two complexes: rapamycin (RAPA)-sensitive mTORC1 and RAPA-insensitive mTORC2. These complexes play…2016 American Transplant Congress
TGFb in Regulatory B Cells-Dependent Tolerance.
Surgery, Massachusetts General Hospital, Boston, MA.
In transplantation, increasing evidence support that B cells can play a major regulatory role in addition to their critical functions in allo-immunity and graft rejection.…2016 American Transplant Congress
Abrogating Donor-Derived Myd88 Signaling Impairs the Recruitment of Recipient Neutrophils and CD8 T Cells into Lung Allografts in Mice.
Objectives: Transplant ischemia reperfusion injury (IRI) mediated primary graft dysfunction (PGD) remains the predominant cause of short- and long-term graft loss in lung transplantation. This…
American Transplant Congress abstracts