ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "knockout"

  • 2018 American Transplant Congress

    NOS2 Deficiency Limits Long Term Survival of Murine Kidney Allografts

    I. Aljabban,1,2 B. Jiang,1 C. Yang,1 T. O'Shea,1 D. Ndishabandi,1 R. White,1 P. Russell,1 R. Colvin,1 J. Madsen,1 A. Alessandrini.1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; 2Pennsylvania State University College of Medicine, Hershey, PA.

    Nitric oxide (NO) is a small molecule derived from L-arginine that governs a myriad of physiologic processes including the antimicrobial and tumoricidal responses. Although NO…
  • 2018 American Transplant Congress

    Loss of HIF-1α in CD4 T Cell Improve Outcome of Mouse Vascularized Osteomyocutaneous Allotransplantation under Costimulation Blockade

    C-.H. Lin,1,2 M. Anggelia,1,2 H. Yang,3 W. Chuang,4 H. Cheng,1 F-.C. Wei,1,2 G. Brandacher.5

    1PRS, Center for VCA, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 2Chang Gung Medical College and Chang Gung University, Taoyuan, Taiwan; 3Nephrology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 4Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 5PRS, Johns Hopkins University School of Medicine, Baltimore, MD.

    Background: Allograft survival depends on the balance of effector T cells (Teff) and regulatory T cells (Tregs). Previous study suggested that the balance is controlled…
  • 2018 American Transplant Congress

    Glycolytic Bias in mTORC2-Deficient Dendritic Cells Potentiates Antigen-Specific Immunity and Accelerates Graft Rejection

    A. Watson,1 H. Dai,1 J. Diaz-Perez,2 A. Menk,3 M. Killeen,2 G. Delgoffe,3 A. Mathers,2 A. Thomson.1

    1Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; 2Dermatology, University of Pittsburgh, Pittsburgh, PA; 3Cancer Institute, University of Pittsburgh, Pittsburgh, PA.

    The mechanistic target of rapamycin (mTOR) is known to function in two complexes: mTOR complex 1 (mTORC1) and mTORC2. While the function of mTORC1 in…
  • 2018 American Transplant Congress

    Lymph Node Stromal Laminins Modulate the Dynamic Balance of the Treg/Th17 Axis

    L. Li, T. Simon, W. Piao, Y. Xiong, V. Saxena, T. Zhang, C. Wagner, J. Bromberg.

    University of Maryland, Baltimore, MD.

    Background: Tolerance and immunity are associated with differential expression of lymph node (LN) stromal laminins α4β1γ1 (411) and α5β1γ1 (511), respectively, which determine how alloreactive…
  • 2018 American Transplant Congress

    Genetically Modified Porcine Erythrocytes: A Cell Model for Studying Human Preformed Antibody-Dependent Xenoimmune Responses In Vitro

    Z. Wang, G. Martens, J. Ladowski, M. Tector, A. Tector.

    Surgery, University of Alabama at Birmingham, Birmingham, AL.

    Background: Powerful gene editing technology is a promising approach to provide genetically-modified pigs as donors for clinical cell, tissue and organ xenotransplantation. Prior to starting…
  • 2018 American Transplant Congress

    Mitochondrial Quality Control through PGC-1α in Syngenic Mouse Heart Transplant

    A. Cherry,1 K. Porter,1 H. Suliman,1 J. Wang,2 M. Mulvihill,2 A. Kirk.2

    1Anesthesiology, Duke University, Durham, NC; 2Surgery, Duke University, Durham, NC.

    Intro: Impaired mitochondrial function plays a role in graft dysfunction after transplant, and recovery is facilitated by mitochondrial quality control (MQC). Two key elements of…
  • 2017 American Transplant Congress

    Dendritic Cell Expression of Rictor (mTORC2), but Not Raptor (mTORC1), Protects Against Renal Ischemia-Reperfusion Injury.

    H. Dai,1,3 N. Rogers,1,2 A. Watson,1 D. Fantus,1 A. Thomson.1

    1Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; 2Westmead Institute for Medical Research, Sydney, Australia; 3Urologic Organ Transplantation Department, the Second Xiangya Hospital, Central South University, Changsha, China

    Background: Dendritic cells (DC) are critical initiators of innate immunity in the kidney and orchestrate inflammation subsequent to ischemia-reperfusion injury (IRI). The mechanistic target of…
  • 2017 American Transplant Congress

    Macrophage Specific Deletion of RhoA Inhibits Fractalkine Signaling and Abrogates Chronic Rejection of Cardiac Allograft.

    M. Kloc, Y. Liu, W. Chen, X. Li, R. Ghobrial.

    Surgery, Houston Methodist Hospital and Research Institute, Houston

    Objective. Chronic rejection of transplanted organs remains unresolved issue in organ transplantation. The chronic rejection is the most common cause of graft loss within 10…
  • 2017 American Transplant Congress

    Abrogating MyD88 Signaling in Donor Lung Resident Hematopoietic Cells Promotes Cell Based Tolerance Induction in Lung Allografts in Mice.

    Z. Zheng,1 J. Wang,1 X. Yeap,1 L. Li,3 L. Zhang,2 M. He,1 X. Luo,2 Z. Zhang.1

    1Comprehensive Transplant Center and Department of Surgery, Chicago, IL; 2Division of Nephrology and Hypertension, Chicago, IL; 3Department of Pathology, Chicago, IL

    Objectives: MyD88 signaling plays an important role in allograft rejection and tolerance induction. This study is designed to determine the cellular base of MyD88 expression…
  • 2017 American Transplant Congress

    Deleting LAG-3 Accelerates Cardiac Allograft Rejection and Augments T Cell Memory in Mice.

    J. Erfe,1,2 C. Yang,1 D. Ndishabandi,1 I. Rosales,1 R. White,1 P. Russell,1 R. Colvin,1 J. Madsen,1 A. Alessandrini.1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; 2Yale School of Medicine, New Haven, CT

    Purpose: Lymphocyte Activation Gene-3 (LAG-3) expresses a transmembrane receptor on activated immune cells such as T cells, NK cells, and plasmacytoid dendritic cells. It is…
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