ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "knockout"

  • 2018 American Transplant Congress

    Glycolytic Bias in mTORC2-Deficient Dendritic Cells Potentiates Antigen-Specific Immunity and Accelerates Graft Rejection

    A. Watson,1 H. Dai,1 J. Diaz-Perez,2 A. Menk,3 M. Killeen,2 G. Delgoffe,3 A. Mathers,2 A. Thomson.1

    1Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; 2Dermatology, University of Pittsburgh, Pittsburgh, PA; 3Cancer Institute, University of Pittsburgh, Pittsburgh, PA.

    The mechanistic target of rapamycin (mTOR) is known to function in two complexes: mTOR complex 1 (mTORC1) and mTORC2. While the function of mTORC1 in…
  • 2018 American Transplant Congress

    Lymph Node Stromal Laminins Modulate the Dynamic Balance of the Treg/Th17 Axis

    L. Li, T. Simon, W. Piao, Y. Xiong, V. Saxena, T. Zhang, C. Wagner, J. Bromberg.

    University of Maryland, Baltimore, MD.

    Background: Tolerance and immunity are associated with differential expression of lymph node (LN) stromal laminins α4β1γ1 (411) and α5β1γ1 (511), respectively, which determine how alloreactive…
  • 2018 American Transplant Congress

    Genetically Modified Porcine Erythrocytes: A Cell Model for Studying Human Preformed Antibody-Dependent Xenoimmune Responses In Vitro

    Z. Wang, G. Martens, J. Ladowski, M. Tector, A. Tector.

    Surgery, University of Alabama at Birmingham, Birmingham, AL.

    Background: Powerful gene editing technology is a promising approach to provide genetically-modified pigs as donors for clinical cell, tissue and organ xenotransplantation. Prior to starting…
  • 2018 American Transplant Congress

    Mitochondrial Quality Control through PGC-1α in Syngenic Mouse Heart Transplant

    A. Cherry,1 K. Porter,1 H. Suliman,1 J. Wang,2 M. Mulvihill,2 A. Kirk.2

    1Anesthesiology, Duke University, Durham, NC; 2Surgery, Duke University, Durham, NC.

    Intro: Impaired mitochondrial function plays a role in graft dysfunction after transplant, and recovery is facilitated by mitochondrial quality control (MQC). Two key elements of…
  • 2018 American Transplant Congress

    Mitochondrial Autophagy Proteins Bnip3 and Nix Maintain Memory B Cell Survival

    S. Kodali,1 H. Sandoval,1 M. Chen,2 J. Wang.1

    1Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston, TX; 2Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX.

    Despite the use of immunosuppressive drugs, allograft rejection remains a major hurdle for the long-term success of organ transplants. Burgeoning evidence implicates memory B cells…
  • 2018 American Transplant Congress

    T-bet and STAT6 Double Deficiency Favors IL-17 Immunity after Lung Transplantation

    F. Liang,1 R. Chen,1 Q. Chen,2 J. Ochando,3 Y. Ding,1 J. Xu.1

    1Department of Immunology, Capital Medical University, Beijing, China; 2Department of Thoracic Surgery, Chaoyang Hospital, Beijing, China; 3Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

    Background: The long-term success of lung transplantation is mainly limited by the development of obliterative bronchiolitis (OB) in which IL-17 plays a critical role. Direct…
  • 2017 American Transplant Congress

    Dendritic Cell Expression of Rictor (mTORC2), but Not Raptor (mTORC1), Protects Against Renal Ischemia-Reperfusion Injury.

    H. Dai,1,3 N. Rogers,1,2 A. Watson,1 D. Fantus,1 A. Thomson.1

    1Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; 2Westmead Institute for Medical Research, Sydney, Australia; 3Urologic Organ Transplantation Department, the Second Xiangya Hospital, Central South University, Changsha, China

    Background: Dendritic cells (DC) are critical initiators of innate immunity in the kidney and orchestrate inflammation subsequent to ischemia-reperfusion injury (IRI). The mechanistic target of…
  • 2017 American Transplant Congress

    Macrophage Specific Deletion of RhoA Inhibits Fractalkine Signaling and Abrogates Chronic Rejection of Cardiac Allograft.

    M. Kloc, Y. Liu, W. Chen, X. Li, R. Ghobrial.

    Surgery, Houston Methodist Hospital and Research Institute, Houston

    Objective. Chronic rejection of transplanted organs remains unresolved issue in organ transplantation. The chronic rejection is the most common cause of graft loss within 10…
  • 2017 American Transplant Congress

    Abrogating MyD88 Signaling in Donor Lung Resident Hematopoietic Cells Promotes Cell Based Tolerance Induction in Lung Allografts in Mice.

    Z. Zheng,1 J. Wang,1 X. Yeap,1 L. Li,3 L. Zhang,2 M. He,1 X. Luo,2 Z. Zhang.1

    1Comprehensive Transplant Center and Department of Surgery, Chicago, IL; 2Division of Nephrology and Hypertension, Chicago, IL; 3Department of Pathology, Chicago, IL

    Objectives: MyD88 signaling plays an important role in allograft rejection and tolerance induction. This study is designed to determine the cellular base of MyD88 expression…
  • 2017 American Transplant Congress

    Deleting LAG-3 Accelerates Cardiac Allograft Rejection and Augments T Cell Memory in Mice.

    J. Erfe,1,2 C. Yang,1 D. Ndishabandi,1 I. Rosales,1 R. White,1 P. Russell,1 R. Colvin,1 J. Madsen,1 A. Alessandrini.1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; 2Yale School of Medicine, New Haven, CT

    Purpose: Lymphocyte Activation Gene-3 (LAG-3) expresses a transmembrane receptor on activated immune cells such as T cells, NK cells, and plasmacytoid dendritic cells. It is…
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