Articles tagged "Kidney"

2016 American Transplant Congress
A Quantitative CD45 Immunohistochemical Assay Allows Precise and Reproducible Measurement of Inflammation in Renal Transplant Biopsies.
V. Walavalkar,¹ S. Bowman,¹ L. Laszik,¹ D. Ikle,² S. Chandran,¹ F. Vincenti,¹ Z. Laszik.¹
¹UCSF, San Francisco, CA; ²Rho, Chapel Hill, NC.
Purpose: Total inflammation (TI) is an important variable for the pathologic work-up of transplant kidney biopsies (TxBx) in the Banff schema. However, current standard pathologic…
2016 American Transplant Congress
Muscle Density Is Associated with Mortality Among Kidney Waitlist Candidates.
R. Reed,¹ S. Nair,² G. Smith,¹ C. Lewis,¹ J. Terry,² J. Carr,² J. Locke.¹
¹School of Medicine, University of Alabama at Birmingham, Birmingham, AL; ²School of Medicine, Vanderbilt University, Nashville, TN.
Background: Morphometric assessments, such as muscle density and body fat distribution, have emerged as strong predictors of cardiovascular risk and post-operative morbidity and mortality. To…
2016 American Transplant Congress
Hydrogen Sulfide Treatment Mitigates Donor Tissue Necrosis During Prolonged Cold Storage and Improves Survival Following Allogeneic Renal Transplantation.
I. Lobb,^1,3 W. Liu,² J. Jiang,³ D. Lian,³ A. Sener.^1,3,4
¹Microbiology and Immunology, Western University Canada, London, ON, Canada; ²Pathology, Western University Canada, London, ON, Canada; ³Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ⁴Surgery, Western University Canada, London, ON, Canada.
Organ procurement is inherently associated with ischemia-reperfusion injury (IRI), resulting from loss and subsequent restoration of blood flow, which is detrimental to short- and long-term…
2016 American Transplant Congress
c-Kit⁺ Cells Are Kidney-Specific Progenitor/Stem Cells with Regenerative Potential.
S. Abreu Gomes,¹ G. Goss,² B. Goldstein,² B. Seidler,³ D. Saur,³ J. Hare,² E. Bevilaqua Rangel.¹
¹Albert Einstein Hospital, Sao Paulo, SP, Brazil; ²University of Miami, Miami; ³Medizinische Klinik, Technische Universität München, Munich, Germany.
Introduction: Identification of progenitor/stem cell populations in mammalian tissues is important for therapeutic applications and for understanding biological processes. We recently reported that c-Kit+ cells…
2016 American Transplant Congress
Would Transplanting Kidneys Currently Being Discarded in the US Place Programs at Risk for Regulatory Review?
J. Snyder, N. Salkowski, B. Thompson, A. Wey, A. Israni, B. Kasiske, S. Leppke.
Scientific Registry of Transplant Recipients, Minneapolis.
In the US in 2014, 17,188 potential kidneys were available from 8594 deceased donors (2014 SRTR/OPTN Annual Data Report). Of these, 25% were not recovered…
2016 American Transplant Congress
Arterial Hypertension After Renal Transplantation in Pediatric Patients: An Analysis of CERTAIN Registry.
R. Sugianto,¹ E. Wühl,² B. Schmidt,¹ K. Krupka,² B. Höcker,² B. Tönshoff,² A. Melk.¹
¹Children's Hospital, Hannover Medical School, Hanover, Germany; ²Division of Pediatric Nephrology, University of Heidelberg, Heidelberg, Germany.
BackgroundOur study aimed to describe the prevalence of hypertension & blood pressure (BP) control as well as influencing factors in pediatric renal transplant patients.MethodCasual BP…
2016 American Transplant Congress
A Novel Quantitative CD45 Immunofluorescence Assay Can Measure Inflammatory Load in Renal Transplant Biopsies with Excellent Reproducibility and Repeatability.
Z. Laszik,¹ D. Dobi,¹ L. Laszik,¹ D. Ikle,² S. Chandran,¹ F. Vincenti.¹
¹UCSF, San Francisco, CA; ²Rho, Chapel Hill, NC.
Purpose: The interobserver reproducibility of the current standard semiquantitative (Banff) grading of inflammation in renal transplant biopsies (TxBx) is suboptimal. We have recently developed a…
2016 American Transplant Congress
Positive Impact of a Pilot Pharmacist-Run Diabetes Pharmacotherapy Clinic in Solid Organ Transplant Recipients.
D. Newland, A. Edwards, R. Hall, P. Maxwell.
University Transplant Center, University Health System and The University of Texas Health Science Center at San Antonio, San Antonio, TX.
Background: Post-transplant diabetes mellitus (PTDM) can lead to significant morbidity and cardiovascular death with a functioning graft. A paucity of literature exists regarding glycemic control…
2016 American Transplant Congress
Signs of a Dying Organ: Beyond Resistance in Subnormothermic Kidney Perfusion.
M. Blum, D. Urcuyo, Q. Liu, B. Soliman, T. Okamoto, D. Goldfarb, C. Quintini.
Cleveland Clinic, Cleveland, OH.
Purpose: In hypothermic machine preservation of the kidney, resistance is often used to assess organ quality. Since no prognostic standard yet exists for subnormothermic ex-vivo…
2016 American Transplant Congress
Hydrogen Sulphide Is an Important Regulator of Erythropoietin Synthesis in Patients with Anemia of Chronic Kidney Disease.
J. Leigh,¹ P. Shao,¹ M. Saha,¹ I. Lobb,¹ A. Pasch,⁵ H. van Goor,⁴ M. Feelisch,² R. Wang,³ A. Sener.¹
¹Western University, London, Canada; ²University of Southhampton, Southhampton, United Kingdom; ³Lakehead University, Thunder Bay, Canada; ⁴University of Gronigen, Groningen, Netherlands; ⁵University Hospital Bern, Bern, Switzerland.
Anemia affects 90% of hemodialysis patients and is a tremendous concern for patients and health care providers. CKD leads to chronic interstitial fibrosis which leads…