ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

5-Year Follow-Up After Live Donor Nephrectomy – A Prospective Cohort Study.

S. Janki,1 E. Mulder,1 L. Dols,1 M. Betjes,2 I. Dooper,3 J. IJzermans.1

1Department of Surgery, Division of HPB and Transplant Surgery, Erasmus University Medical Center, Rotterdam, Netherlands
2Department of Nephrology, Erasmus University Medical Center, Rotterdam, Netherlands
3Department of Nephrology, Radboud University Medical Center, Nijmegen, Netherlands.

Meeting: 2016 American Transplant Congress

Abstract number: A122

Keywords: Donation, Glomerular filtration rate (GFR), Kidney, Outcome

Session Information

Date: Saturday, June 11, 2016

Session Name: Poster Session A: Kidney Donor Outcomes

Session Time: 5:30pm-7:30pm

 Presentation Time: 5:30pm-7:30pm

Location: Halls C&D

Related Abstracts
  • Ten-Year Follow-Up After Live Kidney Donation – A Prospective Cohort Study
  • Acute Operative Complications and 1,5,& 10 Year Outcomes in Living Donors by Type of Live Donor Nephrectomy – UK Cohort Study.

Background

Recently some studies have reported less favorable results after live kidney donation. We investigated therefore which donors will possibly be at risk for chronic kidney disease.

Methods

A 5-year follow-up on renal function, hypertension, and survival was performed of a prospective cohort of 190 donors after live kidney donation. A creatinine based estimated glomerular filtration rate (eGFR) was measured with the CKD-EPI formula.

Results

Clinical data was available for 176 donors. Nine donors died during follow-up due to causes unrelated to donation, and five donors were lost to follow-up.

There was a mean decrease of 31.6% in kidney function as compared with predonation levels from a mean of 91.1 to 62.4 ml/min (p<0.001) after 5-years of follow-up; at least 79 donors (48.8%) had an eGFR of <60 ml/min. Donors with a current eGFR of <60 ml/min were older at the time of donation (58.5 versus 48.5 years, p<0.001) and had a lower eGFR (81.4 versus 100.2 ml/min, p<0.001) compared with donors with a current eGFR of ≥60 ml/min. However, there was no difference in gender (p=0.546). In addition, these donors had a higher incidence of new-onset hypertension (48.1 versus 21.6%, p=0.001).

New-onset hypertensive donors were older at the time of donation (58.7 versus 50.4 years, p<0.001) with a higher BMI (27.0 versus 25.8, p=0.036), and had a higher systolic (143.3 versus 130.6 mmHg, p<0.001) and diastolic (84.9 versus 79.2 mmHg, p<0.001) blood pressure at follow-up compared to non-hypertensive donors.

There was no significant difference in protein to creatinine ratio in urine samples between donors with different eGFR classifications (p=0.406) or between new-onset hypertensive and non-hypertensive donors (p=0.968). No donors were found at risk for end-stage renal disease or renal replacement therapy.

Conclusion

These results indicate a plea for surveillance of new-onset high blood pressure after kidney donation and yearly monitoring of renal function. Future studies are indicated to identify those individuals at risk for a progressive loss of renal function after kidney donation.

CITATION INFORMATION: Janki S, Mulder E, Dols L, Betjes M, Dooper I, IJzermans J. 5-Year Follow-Up After Live Donor Nephrectomy – A Prospective Cohort Study. Am J Transplant. 2016;16 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Janki S, Mulder E, Dols L, Betjes M, Dooper I, IJzermans J. 5-Year Follow-Up After Live Donor Nephrectomy – A Prospective Cohort Study. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/5-year-follow-up-after-live-donor-nephrectomy-a-prospective-cohort-study/. Accessed March 3, 2021.

« Back to 2016 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Penis Transplantation: First U.S. Experience.
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.