Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Halls C&D
Recently some studies have reported less favorable results after live kidney donation. We investigated therefore which donors will possibly be at risk for chronic kidney disease.
A 5-year follow-up on renal function, hypertension, and survival was performed of a prospective cohort of 190 donors after live kidney donation. A creatinine based estimated glomerular filtration rate (eGFR) was measured with the CKD-EPI formula.
Clinical data was available for 176 donors. Nine donors died during follow-up due to causes unrelated to donation, and five donors were lost to follow-up.
There was a mean decrease of 31.6% in kidney function as compared with predonation levels from a mean of 91.1 to 62.4 ml/min (p<0.001) after 5-years of follow-up; at least 79 donors (48.8%) had an eGFR of <60 ml/min. Donors with a current eGFR of <60 ml/min were older at the time of donation (58.5 versus 48.5 years, p<0.001) and had a lower eGFR (81.4 versus 100.2 ml/min, p<0.001) compared with donors with a current eGFR of ≥60 ml/min. However, there was no difference in gender (p=0.546). In addition, these donors had a higher incidence of new-onset hypertension (48.1 versus 21.6%, p=0.001).
New-onset hypertensive donors were older at the time of donation (58.7 versus 50.4 years, p<0.001) with a higher BMI (27.0 versus 25.8, p=0.036), and had a higher systolic (143.3 versus 130.6 mmHg, p<0.001) and diastolic (84.9 versus 79.2 mmHg, p<0.001) blood pressure at follow-up compared to non-hypertensive donors.
There was no significant difference in protein to creatinine ratio in urine samples between donors with different eGFR classifications (p=0.406) or between new-onset hypertensive and non-hypertensive donors (p=0.968). No donors were found at risk for end-stage renal disease or renal replacement therapy.
These results indicate a plea for surveillance of new-onset high blood pressure after kidney donation and yearly monitoring of renal function. Future studies are indicated to identify those individuals at risk for a progressive loss of renal function after kidney donation.
CITATION INFORMATION: Janki S, Mulder E, Dols L, Betjes M, Dooper I, IJzermans J. 5-Year Follow-Up After Live Donor Nephrectomy – A Prospective Cohort Study. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:Janki S, Mulder E, Dols L, Betjes M, Dooper I, IJzermans J. 5-Year Follow-Up After Live Donor Nephrectomy – A Prospective Cohort Study. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/5-year-follow-up-after-live-donor-nephrectomy-a-prospective-cohort-study/. Accessed May 21, 2019.
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