Articles tagged "Kidney transplantation"

2021 American Transplant Congress
Caspase-3 is a Predominant Regulator of Microvascular Dysfunction and Aki-ckd Transition Post Renal Ischemia-reperfusion Injury
S. Lan, F. Migneault, J. Turgeon, M. Bourgault, M. Dieudé, N. Patey, H. Cardinal, M. Hébert
CRCHUM, University of Montreal, Montreal, QC, Canada
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for chronic renal failure. Caspase-3, an effector responsible for apoptosis execution, is activated within tubular epithelial…
2021 American Transplant Congress
Immunosuppression Impacts Panel Reactive Antibody Status in Second Solid Organ Transplant Recipients – A Single Center Experience
J. Patel¹, S. Ali², M. L. Sanders¹, C. P. Thomas¹, D. Axelrod¹, M. Bilal³, E. H. Field³, S. Kuppachi¹
¹University of Iowa Hospitals & Clinics, Iowa city, IA, ²Louis A. Johnson VA Medical Center, Clarksburg, WV, ³Iowa City VA Health Care System, Iowa city, IA
*Purpose: Patients who require a second solid organ transplantation are significantly disadvantaged due to the event of sensitization due to the first transplant. We hypothesized…
2021 American Transplant Congress
Estimated GFR by Serum Myo-inositol, Valine, Creatinine, and Cystatin-c Outperforms Current CKD-epi Equations in Renal Transplant Recipients
J. W. Meeusen¹, F. Stammler², J. Lieske³, M. Grassi², M. Shah⁴, E. Schiffer²
¹Cardiovascular Laboratory Medicine, Mayo Clinic, Rochester, MA, ²Research and Development, Numares, Boston, MA, ³Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, ⁴Clinical Research, Numares, Boston, MA
*Purpose: Current estimated GFR (eGFR) equations using creatinine and/or cystatin C do no perform well in kidney transplant (KTx) recipients. Therefore, some large transplant programs…
2021 American Transplant Congress
Immune Response to Covid-19 in Kidney Transplant Waitlist Patients
P. T. Jindra¹, C. M. Foye¹, I. Sharf², A. Rana¹, T. N. Galvan¹, A. Awan¹, C. A. O'Mahony¹, B. V. Murthy¹
¹Baylor College of Medicine, Houston, TX, ²Baylor St. Luke's Medical Center, Houston, TX
*Purpose: The purpose of this study was to determine the effect of SARS-CoV-2 infection on the immune response in Kidney Transplant Waitlist Candidates (KTWC) and…
2021 American Transplant Congress
Survival Outcomes in Kidney Transplant Recipients Aged 18-60 Years by CMV Discordance Status: A Multivariable Analysis
A. Dinesh¹, T. Shaker¹, S. Jackson², S. Riad³, T. L. Pruett¹
¹Division of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, MN, ²Biostatistics, Analytics Consulting Services- Solid Organ Transplant, M Health Fairview, Minneapolis, MN, ³Department of Medicine, University of Minnesota, Minneapolis, MN
*Purpose: Despite advances in CMV therapeutics, CMV infection can pose significant comorbidity after transplantation. We sought to examine the impact of high-risk CMV discordance in…
2021 American Transplant Congress
Belatacept Pharmacokinetics in Patients with and without Infection
A. Bickenbach¹, M. McGowan¹, B. Miyagawa², T. Mizuno², A. Shields³, A. Christianson¹, P. West-Thielke⁴, J. Leone⁵, E. Woodle¹, D. Kaufman⁶, A. Wiseman⁷, A. Vinks², R. Alloway¹
¹U Cincinnati, Cincinnati, OH, ²Cincinnati Children's Med Center, Cincinnati, OH, ³Christ Hospital, Cincinnati, OH, ⁴UIC, Chicago, IL, ⁵Tampa Gen, Tampa, FL, ⁶U Wisconsin, Madison, WI, ⁷Centura Transplant, Denver, CO
*Purpose: Two belatacept(BELA) fixed mg/kg dosing regimens, less intense(LI) and more intense(MI) were compared. The LI regimen was approved due to the higher risk profile…
2021 American Transplant Congress
Changes to Allocation of En Bloc Deceased Donor Kidneys to Low Epts Patients
A. Robinson¹, M. Pavlakis², V. Casingal³
¹United Network for Organ Sharing, Richmond, VA, ²Beth Israel Deaconess Medical Center, Boston, MA, ³Carolinas Medical Center, Charlotte, NC
*Purpose: The OPTN implemented a policy on September 5, 2019 standardizing en bloc deceased donor kidney allocation in order to efficiently place and utilize kidneys…
2021 American Transplant Congress
Optimizing Usage of High KDPI Kidneys
Y. Ng¹, C. Kling², L. Sibulesky², J. Perkins²
¹Medicine/Nephrology, University of Washington, Seattle, WA, ²Surgery/Transplant, University of Washington, Seattle, WA
*Purpose: Among recipients of high kidney donor profile index (KDPI) kidneys, it is unclear if certain recipients fair better than others. Using data from the…
2021 American Transplant Congress
Current Opioid Utilization Practices of Kidney Transplant Centers in the United States: A National Survey of Institutional Practices
A. Lichvar¹, H. Kim¹, A. Ingemi², J. Jarrett¹
¹University of Illinois at Chicago, Chicago, IL, ²Sentara Healthcare, Norfolk, VA
*Purpose: The opioid epidemic in the United States (US) and the known risks of opioid utilization highlight the need for better understanding of pain management…
2021 American Transplant Congress
Early Hypertransaminasemia in Kidney Transplant Recipient: Influence of Donor Type and Clinical Significance
E. Solà-Porta, M. Redondo-Pachón, S. Núñez-Delgado, C. Arias-Cabrales, M. Mir, A. Buxeda, C. Burballa, M. Crespo, J. Pascual, M. Pérez-Sáez
Nephrology, Hospital del Mar, Barcelona, Spain
*Purpose: The increase in transaminases after kidney transplant (KT) is frequent. Although the cause is unknown, it has been associated with factors such as immunosuppression,…