Articles tagged "Kidney transplantation"

2021 American Transplant Congress
Selective Bcl-2 Inhibition to Deplete Hematopoietic Stem Cells in Bone Marrow Niche: A Novel Approach to Promote Mixed Chimerism
T. Hirose¹, H. Sasaki¹, G. Lassiter¹, D. Ma¹, T. Oura¹, A. Dehnadi¹, A. Cosimi¹, P. Cippa², T. Fehr², T. Kawai¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Institute of Physiology, University of Zurich, Zurich, Switzerland
*Purpose: A recent murine study has shown that successful mixed chimerism is achievable without myelosuppressive treatments by Bcl-2 inhibition. However, the mechanism by which selective…
2021 American Transplant Congress
The Assesment of Pre-transplant Donor-reactive IL-21 Producing T Cells as a Tool to Identify Patients at Risk for Acute Rejection
A. Mendoza Rojas¹, T. van Gelder², R. de Kuiper¹, D. Reijerkerk¹, M. C. Clahsen-van Groningen³, D. A. Hesselink¹, C. C. Baan¹, N. M. van Besouw¹
¹Internal Medicine, Neprology & Transplantation, Erasmus Medical Center, Rotterdam, Netherlands, ²Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, Netherlands, ³Internal Medicine, Pathology, Erasmus Medical Center, Rotterdam, Netherlands
*Purpose: The measurement of panel-reactive antibodies (PRA) has proven valuable in the transplant setting but it does not account for the presence of donor-reactive memory…
2021 American Transplant Congress
Evaluation of Serum Klotho Levels at Early Kidney Post-Transplant
T. Vazquez-Sanchez¹, J. Alonso-Titos¹, M. Sánchez-Niño², E. Sola¹, M. Leon³, V. Lopez¹, P. Ruiz-Esteban¹, E. Porrini⁴, A. Ortiz⁵, D. Hernández¹
¹Nephrology, Instituto de Investigación Biomédica de Málaga (IBIMA). Hospital Universitario Regional de Málaga and University of Málaga. REDinREN (RD16/0009/0006). Málaga. (Spain), Malaga, Spain, ²Nephrology, Instituto de InvestigaciónSanitaria de la FundaciónJiménez Díaz,UniversidadAutónoma de Madrid. REDINREN, Madrid, Spain, ³Pathology, Instituto de Investigación Biomédica de Málaga (IBIMA). Hospital Universitario Regional de Málaga and University of Málaga. REDinREN (RD16/0009/0006). Málaga. (Spain), Malaga, Spain, ⁴Nephrology, Hospital Universitario de Canarias, CIBICAN, Universidadde laLaguna, REDinREN (RD16/0009/0031) Tenerife e Instituto Reina Sofía de Investigación Renal (IRSIN), Malaga, Spain, ⁵Nephrology, Instituto de InvestigaciónSanitaria de la FundaciónJiménez Díaz,UniversidadAutónoma de Madrid. REDINREN, Malaga, Spain
*Purpose: Klotho expression is lowered in patients with chronic kidney disease (CKD). After kidney transplant (KT), serum Klotho levels could be significantly increased compared to…
2021 American Transplant Congress
Observational Study of the Clinical Characteristics and Short-term Outcomes of Kidney Transplant Recipients Diagnosed with Coronavirus-19 Infection (sars-cov2) Requiring Hospitalization in New Orleans
S. Giusti¹, S. Chazin², P. Vaitla³, K. Atiemo⁴, M. Atari¹, A. Paramesh⁴, H. Jeon⁴, A. Vijay⁴, A. Torres⁵, M. Killackey⁴, R. Thimmisetty⁶, J. Garces⁶
¹Tulane University Section of Nephrology & Hypertension, New Orleans, LA, ²Tulane University School of Medicine, New Orleans, LA, ³University of Mississippi Medical Center, Jackson, MS, ⁴Tulane Transplant Institute, New Orleans, LA, ⁵Ochsner Medical Center, New Orleans, LA, ⁶Ochsner Multi-Organ Transplant Institute, New Orleans, LA
*Purpose: Kidney transplant recipients are at increased risk of severe disease and death caused by Coronavirus-19 infection. The role of immunosuppressive medications in the clinical…
2021 American Transplant Congress
Methenamine for the Prevention of Recurrent UTIs Post-Renal Transplant
A. Bigness¹, S. Mohamed², S. Mandala¹, N. Khodieva², K. Robichaux³, H. Mohammed¹, J. Buggs⁴, A. Kumar¹, A. Brueckner⁵, L. Bowman⁵
¹Morsani College of Medicine, University of South Florida, Tampa, FL, ²College of Public Health, University of South Florida, Tampa, FL, ³Honors College, University of South Florida, Tampa, FL, ⁴Transplant Surgery, Tampa General Hospital, Tampa, FL, ⁵Department of Pharmacology, Tampa General Hospital, Tampa, FL
*Purpose: Urinary tract infections (UTIs) are a highly prevalent postoperative complication in kidney transplant recipients (KTRs), occurring in approximately 34% of patients. The common method…
2021 American Transplant Congress
Predictive Factors and Management of Urinary Tract Infections After Kidney Transplantation: A Retrospective Cohort Study
T. Shimizu, Y. Kinoshita, T. Shinzato, D. Iwami
Jichi Medical University, Shimotsuke City, Japan
*Purpose: Urinary tract infection (UTI) is one of the most common infectious complications in kidney transplant recipients. The predictive factors for UTI are controversial because…
2021 American Transplant Congress
The Incremental Cost of Transplanting Patients with 100% cPRA Under the Kidney Allocation System: A Single Center Analysis
R. Gumber, E. Kraus, K. Jackson, N. Alachkar
Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Our group has described excellent three year patient and graft survival in patients with 100% cPRA undergoing kidney transplantation under the Kidney Allocation System…
2021 American Transplant Congress
Trends in the Recovery and Discard of Kidneys from Deceased Donors with Acute Kidney Injury from 2010-2018
C. Liu¹, S. Alasfar², P. P. Reese³, S. Mohan⁴, M. D. Doshi⁵, I. E. Hall⁶, H. R. Thiessen-Philbrook², Y. Jia², D. E. Stewart⁷, C. Parikh²
¹Icahn School of Medicine at Mount Sinai, New York, NY, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³Perelman School of Medicine, Philadelphia, PA, ⁴New York-Presbyterian/Columbia University Irving Medical Center, New York, NY, ⁵University of Michigan, Ann Arbor, MI, ⁶University of Utah School of Medicine, Salt Lake City, UT, ⁷United Network for Organ Sharing, Richmond, VA
*Purpose: Since the donor KDPI score used in KAS is restricted to a single terminal serum creatinine (SCr) measurement, kidneys from donors with transient acute…
2021 American Transplant Congress
Ambient Air Pollution and Changes in Cognitive Function Among Kidney Transplant Recipients
Y. Feng¹, M. Jones², N. Chu², D. Segev¹, M. McAdams Demarco¹
¹Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, ²Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
*Purpose: Although cognitive function among kidney failure patients improves after kidney transplant (KT), cognitive impairment is common and associated with worse post-KT outcomes. Particulate matter…
2021 American Transplant Congress
Changes in Body Mass Index Before and After Kidney Transplant
M. Laub¹, S. Finder², P. Harikrishnan¹, M. Simon³, I. Gani¹, M. Saeed¹, R. Kapoor¹
¹Augusta University Medical Center, Augusta, GA, ²Vanderbilt University Medical Center, Nashville, TN, ³Brandon Wilde, Augusta, GA
*Purpose: Describe changes in body mass index (BMI) before and after kidney transplant and determine the association between BMI and graft loss or mortality.*Methods: Single…