Articles tagged "Kidney transplantation"

2021 American Transplant Congress
CD56^dimCD16^bright NK Cells from Kidney Transplant Recipients with Antibody-mediated Rejection Display Increased Proliferation, Type-1 Activation and Cytotoxic Profile
E. Bailly¹, C. Macedo¹, K. Louis¹, B. Ramaswami¹, M. Lucas¹, C. Bentlejewski¹, P. Randhawa¹, A. Zeevi¹, C. Lefaucheur², D. Metes¹
¹Department of Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, ²INSERM UMR-S976. Endothelium, Inflammation & Alloreactivity, Université de Paris, Paris, France
*Purpose: CD56dimCD16bright NK cells are highly potent for cytotoxicity through cell-mediated cytotoxicity (CMC), antibody-dependent cell-mediated cytotoxicity (ADCC) and INF-γ production. The contribution of NK cells…
2021 American Transplant Congress
Living Donor Kidney Transplantation Racial Disparities Persist Independent of Social Vulnerability
A. C. Killian¹, M. C. McLeod¹, B. Shelton¹, R. D. Reed¹, P. MacLennan¹, H. Qu¹, B. J. Orandi¹, V. Kumar¹, D. Sawinski², R. M. Cannon¹, D. J. Anderson¹, M. J. Hanaway¹, J. E. Locke¹
¹University of Alabama at Birmingham Hospital, Birmingham, AL, ²Hospital of the University of Pennsylvania, Philadelphia, PA
*Purpose: Living donor kidney transplantation (LDKT) confers a significant survival benefit over deceased donor transplantation. Racial disparities in access to LDKT are well recognized, yet…
2021 American Transplant Congress
Impact of SARS-CoV 2 Infection on Graft Function in Kidney Transplant Recipients: An Academic Single Center Experience
S. Nahi, A. Shetty, S. Tanna, J. Leventhal
Northwestern University, Chicago, IL
*Purpose: Kidney transplant recipients are a unique cohort in regard to SARS-CoV 2 susceptibility and clinical course, owing to their immunosuppressed state and propensity for…
2021 American Transplant Congress
Urinary Exosomal Cystatin C and Lipopolysaccharide Binding Protein as Biomarkers for Monitoring Antibody-mediated Rejection After Kidney Transplantation
M. Kim, S. Lim, S. Shin
Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of
*Purpose: This study aims to discover and validate urinary exosomal biomarkers for antibody-mediated rejection (ABMR) after kidney transplantation.*Methods: A total of 60 urine samples from…
2021 American Transplant Congress
Single Center Experience Comparing Two Clinically Available Donor Derived Cell Free DNA Tests
S. Bunnapradist¹, S. Lee², P. Homkrailas³, G. Danovitch³
¹UCLA, Los Angeles, CA, ²Pharmacy, David Geffen School of Medicine at UCLA, Los Angeles, CA, ³David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: Donor derived cell-free DNA (dd cf-DNA), this new technology allows for non-invasive monitoring of graft function. Two most commonly used assays are Prospera (Natera®,…
2021 American Transplant Congress
Role of Trugraf Testing in Kidney Allografts Previously Biopsied for Dysfunction
Y. A. Qazi¹, W. Mon¹, C. Choi¹, S. Qazi², M. Smogorzewski¹
¹Keck Medical Center at USC, Los Angeles, CA, ²Keck Medical Center at USC, La Canada Flt, CA
*Purpose: TruGraf®, can be used as an alternative to surveillance biopsies for ruling out “silent” subclinical acute rejections in transplant patients with stable graft function.…
2021 American Transplant Congress
A Payer’s Perspective: The Cost of Hemodialysis versus Living Donor Kidney Transplant for Kidney Failure Patients in Nigeria
J. Lang¹, I. James², D. Da Rocha Afodu¹, C. G. Okwuonu³, O. Ekwenna¹
¹University of Toledo College of Medicine and Life Sciences, Toledo, OH, ²Surgical Specialists of Charlotte, Matthews, NC, ³Department of Internal Medicine, Nephrology Unit, Federal Medical Centre, Umuahia, Abia State, Nigeria
*Purpose: To primarily quantify the costs of LDKT and HD in Nigeria from a ‘payer’s perspective’ and secondarily inform future cost-effectiveness studies to guide health…
2021 American Transplant Congress
Kidney Transplant Outcomes in HIV+ Recipients: A Single-Center Study
M. Samra¹, A. Hall², I. Tang²
¹Medicine, Edward Hines VA, Hines, IL, ²Medicine, University of Illinois, Chicago, IL
*Purpose: HIV+ patients are eligible to recieve a kidney transplant (KT) provided they meet criteria of undetectable viral load (VL) and CD4 count >200. We…
2021 American Transplant Congress
Impact of Belatacept and Tacrolimus on Cmv Viral Load Control and Relapse in Moderate and High-risk Cmv Serostatus Kidney Transplant Recipients
W. Magua¹, A. C. Johnson¹, G. M. Karadkhele¹, I. R. Badell¹, P. Vasanth¹, M. G. Lyon III², A. K. Mehta², K. A. Easley³, J. Rickert⁴, C. P. Larsen¹
¹Department of Surgery, Emory University, Atlanta, GA, ²Department of Medicine, Emory University, Atlanta, GA, ³Biostatistics and Bioinformatics, Emory University, Atlanta, GA, ⁴RStudio and R Consortium, San Jose, CA
*Purpose: We aim to evaluate the impact of belatacept and tacrolimus on CMV viral load control, remission and relapse in CMV high-risk (serostatus, D+/R-) and…
2021 American Transplant Congress
Hepatitis E Diagnosis and Management After Liver, Kidney, or Heart Transplant: A Single Center Experience
M. Carter¹, M. Fitzmaurice², S. Yeddula², A. Singh², S. Nagai², S. Jafri²
¹Wayne State University School of Medicine, Detroit, MI, ²Henry Ford Health System, Detroit, MI
*Purpose: Transplant-related Hepatitis E virus (HEV) infection is a rarely recognized entity with significant clinical importance given potential for chronic hepatitis post-transplant. We evaluated HEV…