Articles tagged "Kidney transplantation"

2022 American Transplant Congress
Differential Impact of Subclinical Kidney Transplant Rejection in Young Adults
S. Raza¹, G. Agarwal¹, H. Fatima¹, R. Gaston¹, V. Hauptfeld-Dolesjek¹, B. Julian¹, C. Kew¹, V. Kumar¹, S. Mehta¹, S. Ong¹, F. Rosenblum¹, G. Towns¹, R. Mannon², M. Seifert¹
¹School of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²College of Medicine, University of Nebraska, Omaha, NE
*Purpose: Serum creatinine, while an insensitive biomarker of allograft injury, is the current standard for assessing the stability of allograft function and guiding kidney transplant…
2022 American Transplant Congress
Elevated Donor-Derived Cell-Free DNA (dd-cfDNA) in the Early Post-Transplant Period is Associated with an Increased Incidence of Adverse Clinical Outcomes in Kidney Transplant Recipients
D. Wojciechowski¹, A. Patel², S. Anand³, J. Klein⁴, A. Paramesh⁵, P. Sood⁶, G. Shekhtman⁷, N. Agrawal⁷, M. Fei⁷, K. Qu⁷, D. C. Brennan⁸
¹University of Texas, Southwestern, Dallas, TX, ²Saint Barnabas Medical Center, Livingston, NJ, ³Intermountain Healthcare, Murray, UT, ⁴University of Kansas Medical Center, Kansas City, KS, ⁵Tulane University School of Medicine, New Orleans, LA, ⁶University of Pittsburgh Medical Center, Pittsburgh, PA, ⁷CareDx, Brisbane, CA, ⁸Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: Early post-transplant elevations in dd-cfDNA, even in the absence of histologic rejection or other overt pathology, have been suggested to carry a risk of…
2022 American Transplant Congress
Process Evaluation of the Ascent Study: A Hybrid Type 1 Effectiveness-Implementation Trial of a Multi-Level Intervention to Improve Dialysis Provider Knowledge of Kidney Allocation Policy Changes and Increase Kidney Transplant Waitlisting
M. A. Urbanski¹, Y. Lee¹, M. Basu¹, C. Escoffery², R. Hamoda¹, L. Plantinga³, S. O. Pastan¹, R. E. Patzer¹
¹Division of Transplantation, Emory University School of Medicine, Emory University, Atlanta, GA, ²Department of Behavioral Sciences and Health Education, Rollins School of Public Health, Emory University, Atlanta, GA, ³Division of Geriatrics and Gerontology, Emory University School of Medicine, Emory University, Atlanta, GA
*Purpose: Kidney transplant is the optimal treatment for end-stage kidney disease, yet only a fifth of patients are on the waitlist and inequities in access…
2022 American Transplant Congress
Donor-Derived Cell-Free DNA Trends Before and After Rejection Vary Based on Timing of Rejection
C. Rebello¹, K. Guo¹, S. Park², B. Kinsella¹, L. Zhao¹, J. Friedewald¹
¹Northwestern University, Chicago, IL, ²Transplant Nephrology, Northwestern University, Chicago, IL
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) has been used for acute rejection detection and trending levels may help predict future rejection and assess the adequacy of…
2022 American Transplant Congress
Impact of Sars-CoV-2 Vaccination on Donor-Derived Cell Free DNA Levels in Renal Transplant Recipients
H. Alvarado Verduzco, E. Daniel, D. Kim, A. Hussain, S. Mohan, D. Cohen
Columbia University Irving Medical Center, New York, NY
*Purpose: COVID-19 poses a disproportionate threat to renal transplant recipients (RTR), who are chronically immunosuppressed. Studies have indicated a 16% mortality rate compared to
2022 American Transplant Congress
Inflammation After Kidney Transplantation Is Associated With Overall- And Death-censored Graft Loss
T. F. Heldal, T. Jenssen, A. Hartmann, K. Heldal, A. Asberg
Department of Transplantational Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway
*Purpose: Early graft loss after kidney transplantation (KT) is mainly a result of acute rejection, while long-term graft loss episodes are often dependent on multifactorial…
2021 American Transplant Congress
Systematic Screening of Kidney Transplant Patients Points Towards Deficits in Neutralizing Antibody Capacity Against Sars-cov-2
V. Wijtvliet¹, K. K. Ariën², J. Mariën², B. Peeters³, R. Hellemans⁴, A. Massart⁴, S. Van Hees¹, P. Moons⁵, H. Theeten⁶, P. Van Damme⁶, H. Goossens⁷, B. Y. De Winter¹, K. J. Ledeganck¹, D. Abramowicz⁴
¹Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium, ²Department of Biomedical Sciences, Institute of Tropical Medicine and University of Antwerp, Antwerp, Belgium, ³Department of Laboratory Medicine, Antwerp University Hospital, Antwerp, Belgium, ⁴Department of Nephrology and Hypertension, Antwerp University Hospital, Antwerp, Belgium, ⁵Biobank, Antwerp University Hospital, Antwerp, Belgium, ⁶Centre for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium, ⁷Department of Medical Microbiology, Vaccine & Infectious Disease Institute, University of Antwerp, Antwerp, Belgium
*Purpose: The majority of kidney transplant recipients (KTR) is able to develop SARS-CoV-2 antibodies (Abs). Little is known about the virus neutralizing capacity of these…
2021 American Transplant Congress
Outcomes of Kidney Transplantation in Patients with Prosthetic Heart Valves
H. Ouahmi
Nephrology, Dialysis, Transplantation, Nice University Hospital, Nice, France
*Purpose: Due to the aging of the population, a growing number of patients with end-stage kidney disease (ESKD) require cardiac valve replacement. As a consequence,…
2021 American Transplant Congress
Mortality, Risk Factors, and Treatment of Covid-19 Infection in Solid Organ Transplants: A Systematic Review and Meta-analysis
S. Yin, T. Song, Q. Zhong, T. Lin
Urology Institute and Organ Transplantation Center, West China Hospital, Chengdu, China
*Purpose: Outcomes for solid organ transplants (SOT) with COVID-19 have not been summarized, and prognostic factors for COVID-19 in SOT patients are not well established…
2021 American Transplant Congress
Impact of High-Risk EBV Discordance Status on Survival Outcomes in Kidney Transplant Recipients: A Multivariable Analysis
A. Dinesh¹, S. Jackson², T. L. Pruett¹, S. Riad³
¹Division of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, MN, ²Biostatistics, Analytics Consulting Services- Solid Organ Transplant, M Health Fairview, Minneapolis, MN, ³Department of Medicine, University of Minnesota, Minneapolis, MN
*Purpose: High-risk EBV discordance has been linked to Post-Transplant Lymphoproliferative Disorder (PTLD) after kidney transplantation; however, the impact on recipient and graft survival is under-reported.…