Articles tagged "Kidney transplantation"

2015 American Transplant Congress
A Randomized Cross-Over Phase 3b Study of the Pharmacokinetics of Once-Daily Extended Release MeltDose® Tacrolimus (Envarsus® XR) Versus Twice-Daily Tacrolimus in African-Americans (ASERTAA)
J. Trofe-Clark,^1,2 D. Brennan,³ P. West-Thielke,⁴ M. Milone,⁵ M. Lim,² R. Bloom.²
¹Pharmacy Services, Hospital of the University of Pennsylvania, Philadelphia; ²Renal Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia; ³Renal Division, Washington University, St. Louis; ⁴University of Illinois at Chicago, Chicago; ⁵Penn Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
The CYP3A5*1 genotype, highly prevalent in African Americans (AA), commonly necessitates higher tacrolimus (tac) dose requirements and may hinder efforts to obtain therapeutic drug levels.…
2015 American Transplant Congress
The Impact of MYH9 Polymorphic Variant rs5756168 on Kidney Allograft Function
J. Pazik,¹ M. Oldak,² Z. Lewandowski,³ D. Ozieblo,⁴ K. Michalska,⁵ E. Sitarek,¹ A. Sadowska,¹ M. Nowaczyk,⁵ T. Grochowiecki,⁶ J. Malejczyk,⁴ M. Durlik.¹
¹Department of Nephrology and Transplantation Medicine, Medical University of Warsaw, Warsaw, Poland; ²Institute of Physiology and Pathology of Hearing, Warsaw, Poland; ³Department of Epidemiology, Medical University of Warsaw, Warsaw, Poland; ⁴Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland; ⁵Department of Clinical Immunology, Medical University of Warsaw, Warsaw, Poland; ⁶General, Vascular and Transplant Surgery, Medical University of Warsaw, Warsaw, Poland.
The MYH9 gene was identified as a susceptibility locus associated with diminished filtration rate in the course of chronic nephropathies: primary focal segmental glomerulosclerosis (FSGS),…
2015 American Transplant Congress
Renal Resistance Measured During Pulsatile Perfusion and Long-Term Kidney Transplant Outcomes
S. Sandal, R. Sapir-Pichhadze, M. Cantarovich, S. Paraskevas.
McGill University Health Center, Montreal, QC, Canada.
Background: Pulsatile perfusion (PP) has been shown to reduce the incidence of delayed graft function (DGF) and increase short- and long-term kidney transplant (KT) survival.…
2015 American Transplant Congress
Living Kidney Donation in the Elderly: The United Kingdom Experience
Z. Ahmed,¹ R. Tamburrini,¹ L. Pankhurst,² N. Kessaris,¹ N. Mamode.¹
¹Renal and Pancreatic Transplantation, Guy's Hospital, London, United Kingdom; ²Department of Clinicsl Trials and Statistics, NHS Blood and Transplant, Bristol, United Kingdom.
Introduction: The increasing demand for organs has led many institutions to accept elderly patients onto their living donor programmes. However no large UK based datasets…
2015 American Transplant Congress
Kidney Transplant Outcomes in Recipients Older Than 70: A Single Center Experience
M. Yaqub, A. Sharfuddin, M. Mujtaba, D. Mishler, T. Taber, W. Goggins, N. Kassis Akl.
Indiana University Health, Indianapolis, IN.
Age is no longer considered a contraindication to renal transplantation. To date, little is known in regards to the grafts and patients outcomes in elderly…
2015 American Transplant Congress
Potential Urine Protein Biomarkers for Kidney Transplantation Dysfunction Through Quantitative Proteomics
T. Sigdel,¹ N. Salomonis,² C. Nicora,³ J. He,³ W.-J. Qian,³ D. Camp,³ M. Sarwal.¹
¹UCSF, San Francisco, CA; ²Cincinnati Children's Hospital Medical Center, Cincinnati, OH; ³Pacific Northwest National Laboratory, Richland, WA.
Introduction: Inability to effectively monitor transplant injuries leads to immune and non-immune mediated graft dysfunction. A non-invasive tool to monitor such injuries is an unmet…
2015 American Transplant Congress
Clinical and Biochemical Results of BK Virus Nephropathy in Kidney Allograft Recipients
B. Canbakan,¹ I. Akdağ,¹ ö. Merhametsiz,¹ ö. Yayar,² E. Oğuz,¹ M. Kiliç,³ D. Ayli.¹
¹Nephrology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey; ²Nephrology, Atatürk Training and Research Hospital, Ankara, Turkey; ³General Surgery, Atatürk Training and Research Hospital, Ankara, Turkey.
BK virus (BKV) nephropathy has emerged as a significant cause of graft dysfuction in kidney allograft recipients after using powerful immunosupressive treatment protocols in recent…
2015 American Transplant Congress
Dual Kidney Transplantation – Utilising Marginal Kidneys
T. Rana, E. Ablorsu.
Cardiff Transplant Unit, University Hospital of Wales, Cardiff, United Kingdom.
Background: With the increasing shortage of donor kidneys a constant review of organ quality and utilisation is required. Getting any positive result from a potential…
2015 American Transplant Congress
Early Hospital Readmission and Distance from Transplant Center
E. King,¹ L. Kucirka,¹ M. McAdams-DeMarco,^1,2 A. Massie,^1,2 D. Segev.^1,2
¹Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD; ²Epidemiology, Johns Hopkins University, School of Public Health, Baltimore, MD.
Background: Early hospital readmission occurs in 31% of kidney transplant (KT) recipients and may be associated with mechanistic factors not previously captured in patient-level risk…
2015 American Transplant Congress
Desensitization Protocol Including Concomitant Bortezomib and Rituximab Did Not Reduce Calculated PRA Nor Mean MFI Values Among Waitlisted Patients for Deceased Donor Kidney Transplantation
S. Kang,¹ H. Lim,¹ J. Jeong,¹ E. Song,² I. Yun,³ C. Ahn,¹ J. Yang.¹
¹Transplantation Center, Seoul National University Hospital, Seoul, Korea; ²Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Korea; ³Department of Surgery, Konkuk University, Seoul, Korea.
Highly sensitized (HS) patients (pts) seldom have chance to receive deceased donor kidney transplant (DDKT). A desensitization (DES) program including bortezomib was employed to facilitate…