Articles tagged "Kidney transplantation"

2015 American Transplant Congress
Program-Effect Attenuation With Time Posttransplant
N. Salkowski,¹ L. Hunsicker,^1,2 J. Snyder,¹ B. Kasiske.^1,3
¹Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN; ²Department of Medicine, University of Iowa, College of Medicine, Iowa City, IA; ³Department of Medicine, University of Minnesota, Minneapolis, MN.
The program-specific reports produced by SRTR include 1-month, 1-year, and 3-year posttransplant graft and patient survival measures. The 1-month and 1-year measures use the same…
2015 American Transplant Congress
Clinical Subclassifiation of ABMR Phenotypes: Recognizing Variation in Presentation
P. Halloran, M. Lopez, I. Salazar, J. Chang.
Alberta Transplant Applied Genomics Centre, Edmonton, Canada.
The diagnosis of ABMR in kidney transplants is based on ptc-, g- and cg-lesions in biopsies and donor-specific antibody (DSA). To recognize the actual phenotypes…
2015 American Transplant Congress
The Economic Impact of Nonimmune Complications in Contemporary Kidney Transplantation
K. Lentine,¹ M. Schnitzler,¹ D. Axelrod,² D. Segev,³ D. Brennan,⁴ J. Tuttle-Newhall,¹ H. Xiao,¹ L. Kucirka,³ V. Dharnidharka.⁴
¹Saint Louis Univ, St Louis; ²Dartmouth, Lebanon; ³Johns Hopkins, Baltimore; ⁴Washington Univ, St. Louis.
The clinical burden and economic impacts of nonimmune complications after kidney transplant (KT) are incompletely defined.We examined United States Renal System Registry Data for Medicare-insured…
2015 American Transplant Congress
Assessment of IgG Subclass Significance for Early Graft Rejection and Long-Term Survival in HLA-Antibody Incompatible Renal Transplantation: Multivariate Approach
N. Khovanova,¹ D. Lowe,² S. Daga,^1,3 T. Shaikhina,¹ N. Krishnan,³ D. Mitchell,¹ D. Zehnder,¹ D. Briggs,² R. Higgins.³
¹University of Warwick, Coventry, United Kingdom; ²NHS Blood and Transplant, Birmingham, United Kingdom; ³University Hospitals Coventry and Warwickshire, Coventry, United Kingdom.
Donor HLA specific antibodies (DSA) can cause acute rejection and graft lost after renal transplantation. However neither the damaging antibody types, nor their acceptable levels…
2015 American Transplant Congress
Loss of RIPK3 and Caspase-8 Enhance Intrinsic Apoptosis in Tubular Epithelial Cell (TEC) Death and Contributes to Kidney Ischemia Reperfusion Injury (IRI)
B. Sung,¹ Y. Su,³ A. Lau,³ J. Jiang,³ A. Haig,² D. Green,⁴ Z. Zhang,² A. Jevnikar.¹
¹Microbiology and Immunology, Western University, London, ON, Canada; ²Pathology, Western University, London, ON, Canada; ³Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ⁴St. Jude Children's Research Hospital, Memphis, TN.
[Background] Ischemia-reperfusion injury (IRI), a complex limiting factor in organ transplant survival, is related to multiple death pathways. Eliminating the key necroptotic molecule (RIPK3) improves…
2015 American Transplant Congress
Reduced Incidence of Cytomegalovirus Infection in Kidney Transplant Recipients Receiving Everolimus
H. Tedesco-Silva,¹ C. Felipe,¹ A. Ferreira,¹ M. Cristelli,¹ T. Sandes- Freitas,¹ N. Oliveira,¹ W. Aguiar,² G. Bassos,¹ M. Franco,³ M. Gerbase- Lima,⁴ E. Campos,⁴ J. Medina-Pestana.¹
¹Nephrology, Hospital do Rim UNIFESP, Sao Paulo, Brazil; ²Urology, Hospital do Rim UNIFESP, Sao Paulo, Brazil; ³Pathology, UNIFESP, Sao Paulo, Brazil; ⁴Immunogenetic, AFIP, Sao Paulo, Brazil.
BACKGROUND: CMV infection is associated with inferior long-term kidney transplant outcomes. This study compared the incidence of CMV infection/disease in de novo kidney transplant recipients…
2015 American Transplant Congress
Impact of Induction Therapy on Outcomes in HIV + Renal Transplant Recipients
C. Kershaw,¹ C. Rogers,^2,4 M. Pavlakis,^1,2 H. Tang,² C. Alonso,^1,2 K. Khwaja,^2,3 A. Evenson,^2,3 K. Raven,^2,3 M. Wong.^1,2
¹Medicine, Beth Israel Deaconess Medical Center (BIDMC), Boston, MA; ²The Transplant Institute, BIDMC, Boston, MA; ³Surgery, BIDMC, Boston, MA; ⁴Pharmacy, BIDMC, Boston, MA.
Purpose: Kidney transplantation in HIV+ recipients has been complicated by higher than expected acute rejection rates (AR). Induction immunosuppression may or may not impact this…
2015 American Transplant Congress
Impact of Cold Ischemic Time (CIT) and Distance Traveled (DT) on Shipped Kidneys in the OPTN/UNOS Kidney Paired Donation (KPD) Pilot Program (PP)
M. Aeder,¹ D. Stewart,² R. Leishman,² L. Robbins Callahan,² A. Kucheryavaya,² T. Sandholm,³ R. Formica.⁴
¹Univ Hosp Case Med Ctr, Cleveland, OH; ²UNOS, Richmond, VA; ³Carnegie Mellon Univ, Pittsburgh, PA; ⁴Yale Univ, New Haven, CT.
Background: The success of a national KPD program is predicated on excellent early kidney function and graft survival (GS). As other KPD programs have reported…
2015 American Transplant Congress
1-Year Safety and Efficacy of Eculizumab in Adult aHUS Patients, With or Without a History of Renal Transplant
C. Legendre,¹ J. Kincaid,² C. Bedrosian,² C. Loirat.³
¹University Paris Descartes & Hôpital Necker, Paris, France; ²Alexion, Cheshire, CT; ³Assistance Publique–Hôpitaux Paris, Hôpital Robert-Debré, Paris, France.
Background: Atypical hemolytic-uremic syndrome (aHUS) is a life-threatening, chronic disease of complement-mediated TMA. In aHUS, renal transplantation is associated with post-transplant (TP) TMA and ∼50–70%…
2015 American Transplant Congress
Rat dnIKK2-Treg Derived Exosomes Suppress T Cell Proliferation, Generate T Regulatory Cells and Prolong Kidney Allograft Survival
S. Aiello, F. Rocchetta, N. Azzollini, S. Tomasoni, G. Remuzzi, M. Noris, A. Benigni.
Istituto di Ricerche Farmacologiche Mario Negri, Ranica, Italy.
Rat DCs, made immature by adenoviral gene transfer of dnIKK2, generated in MLR a unique population of CD4+ T regulatory cells (dnIKK2-Treg) which potently inhibited…