Articles tagged "Kidney transplantation"

2015 American Transplant Congress
Serum Phosphorus Level Has Bidirectional Association With Graft Failure and Mortality in Kidney Transplant Recipients
H. Jeon,¹ J. An,² K. Joo,¹ C. Lim,² Y. Oh,² C. Ahn,¹ S.-K. Park,³ Y. Kim,¹ Y. Kim,⁴ J. Lee.²
¹Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; ²Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of Korea; ³Department of Internal Medicine, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Republic of Korea; ⁴Department of Surgery, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Republic of Korea.
Hyperphosphatemia in kidney transplant recipients (KTRs) is known to predict a graft and patient survival in several studies. However, studies concerned with hypophosphatemia are scarce.…
2015 American Transplant Congress
Calcineurin (CNI) Exposure Reduces the Risk of Post-Transplant DSA After Deceased Donor Kidney Transplantation
R. Pelletier, A. Rajab, G. Bumgardner, M. Henry.
General Surgery, The Ohio State University, Columbus, OH.
We use ATG induction with immediate rapamune (Rapa) and delayed CNI immunosuppression following kidney transplantation. Mycophenolic acid (MPA) is substituted for CNI to avoid renal…
2015 American Transplant Congress
The Impact of Cytokine Release Caused By Induction Immunosupression On Nitric Oxide in Renal transplantation
R. Johns,^1,2 M. Laftsidis,² E. Burrows,² F. Edwards,² E. Ablorsu,² P. James,¹ A. Phillips,^1,2 A. Asderakis.²
¹University of Cardiff, Cardiff, United Kingdom; ²University Hospital of Wales, Cardiff, United Kingdom.
IntroductionVarying induction immunosuppression regimens have a differential impact on the pattern of cytokine release. Pro-inflammatory cytokines stimulate endothelial cells causing secretion of NO. Serum nitrite…
2015 American Transplant Congress
"What's the Mileage?" Determining the Length of Time in Which Renal Function Returns to Pre-Calcineurin Discontinuation Levels in Patients With Interstitial Fibrosis
A. Diez, J. Von Visger, U. Nori, T. Pesavento, M. Henry, E. Davies, R. Pelletier.
The Ohio State University, Columbus.
Calcineurin Inhibitors (CNI) use may be associated with progressive renal dysfunction. Clinical trials have shown that CNI minimization or discontinuation may aid in improvement in…
2015 American Transplant Congress
Intra-Lymphocyte Concentrations of Mycophenolic Acid Correlate With the Incidence of Early Graft Rejection in Renal Transplant Recipients
Z. Md Dom,² J. Coller,² R. Carroll,³ A. Somogyi,² B. Sallustio.¹
¹Clinical Pharmacology, The Queen Elizabeth Hospital, Adelaide, Australia; ²Discipline of Pharmacology, Univeristy of Adelaide, Adelaide, Australia; ³Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, Australia.
Introduction: Although routine therapeutic drug monitoring of mycophenolic acid (MPA) concentrations in plasma has been recommended to individualize MPA doses in transplant recipients, little is…
2015 American Transplant Congress
Arterial Hypertension and the Use of Antihypertensive Medication in Pediatric Renal Transplant Patients: An Analysis of the CERTAIN Registry
R. Sugianto,¹ E. Wühl,² B. Schmidt,¹ S. Geyer,³ K. Krupka,² B. Höcker,² B. Tönshoff,² A. Melk.¹
¹Department of Pediatric Nephrology, Hannover Medical School, Hanover, Germany; ²Division of Pediatric Nephrology, University of Heidelberg, Heidelberg, Germany; ³Department of Medical Sociology, Hannover Medical School, Hanover, Germany.
BackgroundOur study aimed to describe the prevalence of hypertension, blood pressure (BP) control and the use of antihypertensive (AH) drugs in pediatric renal transplant patients.MethodsCasual…
2015 American Transplant Congress
Low Dose Valganciclovir Prophylaxis Following Renal Transplantation With Steroid Free Immunosuppression
J. Chen,¹ A. Shah,² M. Sauer,¹ T. Taber,³ A. Sharfuddin,³ M. Yaqub,³ D. Mishler,³ J. Powelson,⁴ W. Goggins.⁴
¹Pharmacy, IU Health, Indianapolis; ²Surgery, Thomas Jefferson University, Philadelphia; ³Nephrology, Indiana University School of Medicine, Indianapolis; ⁴Surgery, Indiana University School of Medicine, Indianapolis.
AST ID guidelines recommend a valganciclovir (VGCV) prophylaxis dose of 900 mg daily for patients with CrCL > 60 mL/min with reduced dose for renal…
2015 American Transplant Congress
Regional Efficiency in Deceased Donor Utilization for Kidney Transplantation
K. Schnier,¹ N. Turgeon.²
¹School of Social Sciences, Humanities and Arts, University of California, Merced, Merced, CA; ²Department of Surgery, Emory University School of Medicine, Atlanta, GA.
Background: There currently exists regional variation in the supply of deceased donors as well as the demand for kidney transplantation. This has stimulated a growing…
2015 American Transplant Congress
Long Term Outcomes of Tocilizumab Therapy for DSA+ Antibody Mediated Rejection (ABMR) Resistant to IVIG + Rituxan (I+R) Treatment
J. Choi,¹ A. Vo,¹ J. Kahwaji,¹ M. Haas,² N. Reinsmoen,³ D. Puliyanda,¹ A. Peng,¹ R. Villicana,¹ S. Jordan.¹
¹CTC, Cedars Sinai, Los Angeles, CA; ²Pathology, Cedars-Sinai, Los Angeles, CA; ³HLA Laboratory, Cedars-Sinai, Los Angeles, CA.
Intro: Limited options are available for treatment of ABMR in highly-HLA sensitized patients (HS). Treatment options include I+R, PLEX+I+/- R, C5-inhibitor & bortezomib. Approximately 25%…
2015 American Transplant Congress
Post-Kidney Transplant Infections in Desensitized Patients Receiving Thymoglobulin or Daclizumab Induction: Results of a Randomized Clinical Trial
B. Orandi,¹ J. Locke,² E. Kraus,³ B. Lonze,¹ N. Desai,¹ N. Dagher,¹ N. Alachkar,³ C. Simpkins,⁴ F. Naqvi,³ D. Segev,¹ R. Montgomery,¹ R. Avery.³
¹Department of Surgery, Johns Hopkins University, Baltimore; ²Department of Surgery, University of Alabama--Birmingham, Birmingham; ³Department of Medicine, Johns Hopkins University, Baltimore; ⁴Department of Surgery, Dartmouth, Lebanon.
Live donor kidney transplant recipients requiring desensitization for donor-specific antibody, who were enrolled in a single-center randomized trial of thymoglobulin vs. daclizumab induction, were evaluated…