Articles tagged "Kidney transplantation"

2015 American Transplant Congress
Clinical Relevance of C3d-Binding Donor-Specific Antibodies in Late Kidney Allograft Failure
J. Lan, D. Gjertson, Y. Zheng, DeKAF Investigators, E. Reed, M. Cecka.
Path, UCLA, LA, CA.
Background: The objective of this study was to investigate the prognostic value of C3d-binding donor-specific antibodies (DSA) in determining late kidney allograft failure.Methods: 1048 patients…
2015 American Transplant Congress
Long-Term Analysis of a Placebo-Controlled Trial of C1-INH for Prevention of Antibody-Mediated Rejection
A. Vo, J. Choi, J. Kahwaji, D. Puliyanda, A. Peng, R. Villicana, S. Jordan.
Kidney Transplant, Cedars-Sinai Medical Center, Los Angeles, CA.
Introduction: Desensitization (DES) strategies focus primarily on antibody reduction using IVIG, rituximab ± PLEX to prevent DSA-induced antibody-mediated rejection (ABMR) and rebound B-cell activity. Recently,…
2015 American Transplant Congress
Ureteral Length in Living Donor Kidney Transplantation; Does Size Matter?
L. Ooms, I. Slagt, J. IJzermans, T. Terkivatan.
Transplant Surgery, Erasmus Medical Center, Rotterdam, Netherlands.
Introduction: Urological complications are common after kidney transplantation. The aim of this study is to evaluate the effect of ureteral length on ureter strictures or…
2015 American Transplant Congress
Effectiveness of Protocol-Driven Induction Therapy in Adult Kidney Transplant Recipients
J. Casale, J. Fleming, D. Taber, C. Staino, K. Boyle, K. Covert, N. Pilch, H. Meadows, C. Mardis, K. Chavin, C. Bratton, J. McGillicuddy, T. Srinivas, P. Baliga.
MUSC, Charleston, SC.
Background: Induction therapy significantly improves graft outcomes in kidney transplantation, but the optimal agent based on patient characteristics and immunologic risk is unknown. While many…
2015 American Transplant Congress
Clinical and Pathologic Predictors of Response to Belatacept Conversion
S. Patel, H. Morris, D. Cohen, S. Mohan, L. Ratner, R. Crew.
Columbia Universtiy, New York.
INTRO: Calcineurin inhibitors have improved kidney transplant and recipient survival, their use has significant nephrotoxicity. Belatacept is a recently approved immunosuppressant that is not nephrotoxic…
2015 American Transplant Congress
Improved Long-Term Graft Survival in Renal Transplant Recipients With Donor Specific Antibodies (DSA) After Mycophenolic Acid Escalation
L. Rebellato,¹ K. Parker,² F. Rana,³ S. Kendrick,⁴ C. Morgan,⁵ C. Haisch,⁵ M. Everly,⁶ R. Harland,⁵ P. Bolin.³
¹Pathology and Laboratory Medicine, East Carolina University, Brody School of Medicine, Greenville, NC; ²Vidant Medical Center, Greenville, NC; ³Internal Medicine, East Carolina University, Brody School of Medicine, Greenville, NC; ⁴Eastern Nephrology Associates, Greenville, NC; ⁵Surgical Immunology and Transplantation, East Carolina University, Brody School of Medicine, Greenville, NC; ⁶Terasaki Foundation, Los Angeles, CA.
Background: DSA formation in post-renal transplant patients is associated with chronic rejection and graft failure. Previous studies in our population indicate DSA formation is a…
2015 American Transplant Congress
Is BK Viral Subtype Distribution of Donor And/Or Recipient Important for Subsequent BK Viral Infection After Living-Donor Transplantation?
A. Schwarz,¹ S. Linnenweber-Held,¹ H. Haller,¹ A. Heim,² C. Schmitt.²
¹Nephrology, Hannover Medical School, Hannover, Germany; ²Virology, Hannover Medical School, Hannover, Germany.
Background: Source and risk factors for developing BK virus (BKV) infection after renal transplantation are unresolved. By genotyping of urine and blood, we looked for…
2015 American Transplant Congress
Interim Safety Experience in Transplant Patients Treated With Belatacept (Nulojix) in the Post-Approval Setting
T. Kou, J. Braga, S. Sibabrata, J. Preston, M. Harler, A. Gomez.
Bristol-Myers Squibb Company, Princeton, NJ.
Purpose: Belatacept is a selective T-cell costimulation blocker indicated for prophylaxis of organ rejection in adult patients receiving a kidney transplant in combination with basiliximab…
2015 American Transplant Congress
Excellent Outcomes With Deceased Donor Kidney Transplants With a Terminal Creatinine >= 3
L. Matsuoka,¹ E. Alicuben,¹ K. Woo,¹ H. Shidban,¹ Y. Qazi,² M. Smogorzewski,² S. Alexopoulos.¹
¹Department of Surgery, USC Keck School of Medicine, Los Angeles, CA; ²Department of Nephrology, USC Keck School of Medicine, Los Angeles, CA.
Purpose: Kidneys from deceased donors with elevated creatinine are frequently discarded due to concerns about poor post-transplant outcomes. In this study we sought to determine…
2015 American Transplant Congress
Recipient Immunity to Murine Cytomegalovirus Influences Natural Killer Cell Responses in Infected Renal Allografts
M. Shimamura,¹ M. Li,¹ B. Chen,² J. George.²
¹Pediatric Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL; ²Cardiothoracic Surgery, University of Alabama at Birmingham, Birmingham.
BACKGROUND: Human cytomegalovirus (CMV) is associated epidemiologically with renal allograft loss, but the impact of recipient CMV immunity upon graft survival is unclear. Natural killer…