Articles tagged "Kidney transplantation"

2016 American Transplant Congress
The Intrarenal Resistive Index Measured After Transplantation Is Determined by the Upstream Vascular System of the Recipient.
L. Heylen,¹ M. Naesens,¹ B. Sprangers,¹ S. Heye,² P. Verhamme,³ I. Jochmans,⁴ D. Monbaliu,⁴ J. Pirenne,⁴ D. Kuypers,¹ K. Claes.¹
¹Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium; ²Radiology, University Hospitals Leuven, Leuven, Belgium; ³Cardiovascular Medicine, University Hospitals Leuven, Leuven, Belgium; ⁴Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium.
Objective: We recently demonstrated that the renal resistive index, measured after renal transplantation, reflects recipient characteristics, like recipient age and central hemodynamics, and not so…
2016 American Transplant Congress
Kidney Graft Homing of De Novo Donor Specific HLA Antibodies Is an Early Step within the Antibody-Mediated Graft Damage Process.
A. Nocera,¹ M. Cioni,² A. Tagliamacco,¹ A. Innocente,³ I. Fontana,⁴ A. Magnasco,² A. Nocco,³ A. Sementa,² G. Garibotto,¹ G. Ghiggeri,² M. Cardillo,³ P. Comoli,⁵ F. Ginevri.²
¹Transplant Immunology and Nephrology, University of Genova, Genova, Italy; ²Nephrology and Pathology, G. Gaslini Institute, Genova, Italy; ³Transplantation Immunology, Fondazione Cà Granda Ospedale Maggiore Policlinico, Milano, Italy; ⁴Kidney Transplant Surgery, IRCCS S.Martino-IST, Genova, Italy; ⁵Pediatric Hematology/Oncology, IRCCS Fondazione Policlinico S. Matteo, Pavia, Italy.
In this study, by a parallel analysis on sera and graft biopsies we have analyzed, in a pediatric cohort of unsensitized recipients of a first…
2016 American Transplant Congress
Alemtuzumab Induction Therapy in Elderly Kidney Transplant Recipients.
I. Yakubu,¹ B. Masters,¹ B. Ravichandran,¹ T. Sparkes,¹ M. Moss,¹ F. Rasetto,¹ S. Jonchhe,¹ B. Thomas,² N. Costa,² D. Leeser,² S. Bartlett,² A. Haririan.²
¹Pharmacy, University of Maryland Medical Center, Baltimore; ²University of Maryland Medical Center, Baltimore.
Background: In descriptive studies, alemtuzumab has been associated with an escalating risk of death and graft loss in elderly (≥65 years) kidney transplant recipients. However,…
2016 American Transplant Congress
Does Donor and Recipient Age Disparity Make a Difference with Expanded Criteria Donors?
M. Khan,¹ K. Jones,¹ H. El-Hennawy,¹ A. Farney,¹ J. Rogers,¹ G. Orlando,¹ A. Reeves-Daniel,² A. Palanisamy,² M. Gautreaux,³ S. Iskandar,³ W. Doares,⁴ S. Kaczmorski,⁴ R. Stratta.¹
¹Surgery, Wake Forest, Winston-Salem, NC; ²Internal Medicine, Wake Forest, Winston-Salem, NC; ³Pathology, Wake Forest, Winston-Salem, NC; ⁴Pharmacy, Wake Forest, Winston-Salem, NC.
The critical shortage of donor organs challenges the transplant community to optimize the use of organs from all consented deceased donors (DD). The purpose of…
2016 American Transplant Congress
Living Kidney Donor Preferences: A Novel Use of a Visual Instrument to Quantify ESRD Risk Acceptance.
C. Thiessen,¹ J. Gannon,¹ D. Dobosz,¹ S. Li,¹ D. Gray,² A. Mussell,² K. Kennedy,³ L. Skrip,¹ E. Gordon,³ P. Reese,² S. Kulkarni.¹
¹Yale U, New Haven; ²U Pennyslvania, Philadelphia; ³Northwestern U, Chicago.
BackgroundGiven new data about the estimated lifetime risk of ESRD among living kidney donors (LKD) (Muzaale 2014), we elicited their willingness to accept the risk…
2016 American Transplant Congress
Predictive Model of Delayed Graft Function in Machine Perfused Kidney Transplantation: Model Validation Using Decision Curve Analysis.
K. Ravindra,¹ S. Sanoff,¹ D. Vikraman,¹ U. Patel,¹ M. Ellis,¹ E. Squires,² D. Sudan,¹ W. Irish.¹
¹Surgery, Duke University, Durham, NC; ²Half Moon Bay, Raleigh.
Introduction: Predictive model for delayed graft function (DGF) was developed (Am J Transpl 2010; 10: 2279–86)excluding organs that were machine perfused (MP). Currently, approximately 50%…
2016 American Transplant Congress
Preimplantation and Post-Transplant Serial Biopsies of Standard and Extended Criteria Donor Kidneys: Intragraft Molecular Profiles and Effect of Different Immunosuppressive Protocols.
C. Mazeti,¹ H. Caldas,¹ I. Fernandes-Charpiot,² M. Baptista,² M. Abbud-Filho.^1,2,3
¹Laboratory of Immunology and Experimental Transplantation, Medical School, Sao Jose do Rio Preto, SP, Brazil; ²Department of Medicine/Nephrology, Medical School, Sao Jose do Rio Preto, SP, Brazil; ³Urology and Nephrology Institute, Urology and Nephrology Institute, Sao Jose do Rio Preto, SP, Brazil.
Background: Use of extended criteria donor kidneys (ECD) carries the fear of to transplant of inferior quality and therefore of high discard rate. Clinical tools…
2016 American Transplant Congress
Early Hospital Readmission After Kidney Transplantation: Seasonality, Causes and Prognosis.
M. Tavares, M. Cristelli, L. Viana, M. de Paula, H. Silva Junior, J. Medina Pestana.
Nephrology Division, Hospital do Rim Foundation, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
Background: In the general population, 30-day hospital readmission rate is a well-accepted quality metric and a predictor of mortality. A growing body of data suggests…
2016 American Transplant Congress
Risk Factors for the Development of CMV Viremia in a Cohort of Morbidly Obese Kidney Transplant Recipients Under Low Dose Valganciclovir Prophylaxis.
J. Thielke,¹ N. Jasiak,¹ N. Hilal,¹ S. Salah,¹ E. Benedetti,² P. West-Thielke.²
¹Pharmacy Practice, Univ of IL-Chicago Medical Center, Chicago, IL; ²Dept of Surgery, Univ of IL-Chicago Medical Center, Chicago, IL.
Background: The rate of Cytomegalovirus infections in kidney transplant recipients drastically diminished with the advent of oral ganciclovir and subsequently valganciclovir. However it continues to…
2016 American Transplant Congress
Enhanced Natural Killer Responsiveness Is a Potent Cytotoxic Mechanism Associating to Kidney Allograft Dysfunction and Pathogenic Effects of Donor-Specific Antibodies (DSA).
P. Paul,^1,2 T. Legris,³ C. Picard,⁴ D. Todorova,^1,2 L. Lyonnet,¹ L. Daniel,⁵ B. Dussol,^3,6 V. Moal,³ H. Vacher Coponat,³ Y. Berland,³ F. Dignat-George,^1,2 S. Burtey.^2,3
¹Hematology, Assistance Publique Hopitaux Marseille, Marseille, France; ²UMR-1076, VRCM, Aix Marseille University, INSERM, Marseille, France; ³Nephrology Dialysis Renal Transplantation Center, Assistance Publique Hopitaux Marseille, Marseille, France; ⁴Immunogenetics, Etablissement Français du Sang, Marseille, France; ⁵Anatomy, Pathology, Neuropathology, Assistance Publique Hopitaux Marseille, Marseille, France; ⁶Center for Clinical Investigation, Assistance Publique Hopitaux Marseille, Marseille, France.
While antibody mediated rejection (ABMR) is a major cause of kidney transplant loss, the role of Natural Killer cells (NK) as immune effectors of complement-independent…