Articles tagged "Kidney transplantation"

2016 American Transplant Congress
Digital Kidney Biopsy Evaluation: Quantification of Macrophage Prevalence in a Cross Sectional Study.
J. Schmitz,¹ A. Khalifa,¹ H. Haller,² H. Kreipe,¹ F. Feuerhake,¹ J. Bräsen.¹
¹Institute of Pathology, Hannover Medical School, Hannover, Germany; ²Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.
Standardized markers based on quantitative and qualitative evaluation of immune cell mass and localization in kidney biopsies may help in diagnosis and prognosis in transplantation…
2016 American Transplant Congress
Complement Receptor C5aR2 Deletion in Kidney Transplantation in Mice Attenuates Renal Damage.
A. Thorenz,¹ R. Chen,¹ K. Hueper,² B. Hensen,² C. Klemann,³ M. Meier,⁴ A. Klos,⁵ F. Gueler.¹
¹Nephrology, Medical School, Hannover, Germany; ²Radiology, Medical School, Hannover, Germany; ³Paediatric Surgery, Medical School, Hannover, Germany; ⁴Central Animal Facility, Medical School, Hannover, Germany; ⁵Microbiology, Medical School, Hannover, Germany.
ObjectiveThe complement receptors C5aR1 and C5aR2 serve distinct roles in immune regulation. In kidney transplantation the early post-implant ischemia reperfusion injury (IRI) causes rapid complement…
2016 American Transplant Congress
The Effect of the Use of a TNF-Alpha Inhibitor in Hypothermic Machine Perfusion on Kidney Function After Transplantation.
P. Diuwe,¹ P. Domagala,¹ R. Kieszek,¹ M. Wszola,¹ M. Serwanska-Swietek,¹ L. Paczek,² M. Durlik,³ A. Chmura,¹ A. Kwiatkowski.¹
¹Department of General Surgery and Transplantology, Medical University of Warsaw, Warsaw, Poland; ²Department of Immunology, Transplantology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland; ³Department of Transplantology and Nephrology, Medical University of Warsaw, Warsaw, Poland.
Organ damage associated with processes occurring during the ischaemic period as well as during and after organ reperfusion is an important problem of transplantation medicine.The…
2016 American Transplant Congress
Schisandra Sphenanthera Extract Facilitates Anti-Tuberculosis Treatment Post Renal Transplantation Through Increasing Bioavailability of Tacrolimus.
R. Deng,¹ L. Zhang,¹ L. Liu,¹ H. Fu,² J. Li,¹ Q. Fu,¹ C. Wang.¹
¹Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; ²Infectious Medicine Department, Guangzhou Infectious Disease Hospital, Guangzhou, China.
Background: Hepatoprotective agent Schisandra sphenanthera extract (SchE) facilitates rifampicin-containing anti-tuberculosis (TB) chemotherapy by stabilizing the Tacrolimus (FK506) blood concentration through increasing the oral bioavailability, which…
2016 American Transplant Congress
Compensating Live Kidney Donors: The Views of United States Voters.
J. Fisher,¹ T. Peters,² R. Gish,³ R. Howard.⁴
¹Surgery, Scripps Center for Organ Transplantation, La Jolla, CA; ²Surgery, University of Florida, Jacksonville, FL; ³Medicine, Stanford University Medical Center, Stanford, CA; ⁴Surgery, LifeQuest Organ Recovery Services, Gainesville, FL.
Purpose: An increasing number of U.S. patients die waiting for a kidney transplant. Financial compensation of living donors is one possible remedy for the organ…
2016 American Transplant Congress
Nuclear Factor of Activated T-Cells Post-Renal Transplant.
K. Tornatore,^1,4 K. Attwood,² O. McGuire,³ K. O'Loughlin,³ R. Venuto,⁴ H. Minderman.³
¹Translational Pharmacology Research Center, School of Pharmacy, Buffalo; ²Biostatistics, School of Public Health, Buffalo; ³Flow Cytometry Laboratory, Roswell Park Cancer Institute, Buffalo; ⁴Medicine, School of Medicine, University at Buffalo, Buffalo.
Background: Nuclear Factor of Activated T-cells (NFAT1) is a transcription factor regulating the expression of key targets involved with cellular immune function. Calcineurin is a…
2016 American Transplant Congress
Pneumocystis jirovecii Pneumonia: Late and Serious Complication Among Kidney Transplant Recipients.
L. Viana, T. Sandes, M. Cristelli, A. Oliveira, D. Santos, H. Tedesco-Silva, J. Medina-Pestana.
HOSPITAL DO RIM-UNIFESP, São Paulo, Brazil.
We report 50 confirmed PJP cases that occurred in kidney transplant patients between 06/16/2011 and 10/17/2015 in a single center.In the studied period, there were…
2016 American Transplant Congress
Mycophenolate Mofetil Dose Reduction Are Associated with the Risk of Acute Rejection and Graft Failure After Renal Transplantation.
A. El-Agroudy,¹ A. Taher,² A. Alaradi,² B. Alhayki,² S. Gareeb,² E. Farid.²
¹Internal Medicine, College of Medicine, Arabian Gulf University, Manama, Bahrain; ²Nephrology, Salmaniya Medical Complex, Manama, Bahrain.
Background: Mycophenolate mofetil (MMF) is a highly effective immunosuppressive agent in transplant therapy. Although MMF is generally well tolerated, optimal therapy may be limited by…
2016 American Transplant Congress
Therapeutically Equivalent Results to Caucasians in Black Kidney Transplant Recipients Using ASTAGRAF XL^® Despite a Higher Degree of HLA Mismatch : A Post-Hoc Analysis of Phase III Data from Over 2000 Patients.
J. Schwartz, S. Wilson, F. Shi, N. Undre, M. Kumar.
Astelleas Pharma Global Develepment, Northbrook, IL.
INTRO: When contemplating the use of a new immunosuppressant agent in kidney transplantation, measuring outcomes in potentially vulnerable populations is of paramount concern. As such,…
2016 American Transplant Congress
Combination of Delayed Kidney Transplant (KT) and Better Quality Kidneys Offers Excellent Patient Survival in Combined Liver-Kidney Transplantation (CLKT).
B. Ekser, R. Mangus, J. Fridell, C. Kubal, D. Bayt, S. Nagaraju, P. Mihaylov, J. Powelson, W. Goggins, A. Tector.
Transplant Division, Department of Surgery, Indiana University, Indianapolis, IN.
Background: Despite prioritizing high MELD patients with the share-35 policy, patient survival in CLKT is relatively low. We previously showed the positive impact of delayed…