Articles tagged "Kidney transplantation"

2016 American Transplant Congress
Many Discarded Kidneys Are Similar to Kidneys Accepted for Transplantation as Judged by Their Histologic Lesions and Molecular AKI Scores.
K. Famulski,¹ J. Reeve,¹ O. Aubert,² A. Loupy,² S. Niderhaus,³ J. Bromberg,³ P. Halloran.¹
¹University of Alberta, Edmonton, Canada; ²Necker Hospital, Paris, France; ³University of Maryland, Baltimore.
There is an increase in the number kidneys from older brain dead donors (DBD). Many are discarded based on conventional features (clinical or histology). Thus…
2016 American Transplant Congress
Standardized Pre-Implantation Kidney Biopsies of Expanded Criteria Donors to Improve the Kidney Donor Profile Index (KDPI) for the Evaluation of Marginal Donors.
A. Sánchez-Escuredo,¹ A. Sagasta,² F. Diekmann,¹ I. Revuelta,¹ L. Rodas,¹ D. Paredes,³ M. Musquera,⁴ N. Esforzado,¹ M. Ricart,¹ F. Cofan,¹ V. Torregrosa,¹ J. Campistol,¹ M. Sole,² F. Oppenheimer.¹
¹Nephrology and Renal Transplant, Hospital Clínic, Barcelona, Spain; ²Pathology, Hospital Clínic, Barcelona, Spain; ³Transplant Foundation, Hospital Clínic, Barcelona, Spain; ⁴Urology, Hospital Clínic, Barcelona, Spain.
There is no consensus of selection criteria used to allocate renal transplants from expanded criteria donors (ECD). The Kidney Donor Profile Index (KDPI) has been…
2016 American Transplant Congress
Gene Expression Microarray Analysis of Purified CD16-Stimulated Human NK Cells and Indication Biopsies Supports a CD16-Mediated Role for NK Cells in Antibody-Mediated Kidney Rejection.
M. Parkes,¹ P. Halloran,¹ L. Hidalgo.²
¹Dept. of Medicine, University of Alberta, Edmonton, AB, Canada; ²Dept. of Laboratory Medicine & Pathology, University of Alberta, Edmonton, AB, Canada.
BACKGROUND: CD16α mediates NK cell responses to donor-specific IgG antibodies (DSA), and shares mechanisms with effector T cell receptor (TCR) stimulation. Whether CD16α-inducible transcripts are…
2016 American Transplant Congress
Early Hospital Readmission Among Immunologically Vulnerable Kidney Transplantation Recipients.
E. King, B. Orandi, S. Bae, X. Luo, D. Segev.
Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD.
BACKGROUND: We previously established that 31% of all kidney transplant (KT) recipients experience early hospital readmission (EHR), or readmission within 30 days of discharge following…
2016 American Transplant Congress
Reduced Incidence of Rejection in AB0-incompatible Kidney Transplantation – Five Year Follow-Up in a Single Center.
A. Weidemann, F. Karpf, T. Dienemann, K. Birkner, J. Jacobi, K.-U. Eckardt.
Nephrology and Hypertension, Universitaet Erlangen-Nuernberg, Erlangen, Germany.
Introduction:Living kidney donation is the method of choice to expand the donor pool in times of severe organ shortage. In many centers, AB0-incompatible kidney transplantation…
2016 American Transplant Congress
Exposure Analysis for the Composite Efficacy Endpoints in the US92 Phase 3 Kidney Transplantation Trial to Understand Center Effects.
F. Shihab, B. Kaplan, K. McCague, D. Patel, F. Vincenti.
University of Utah, Salt Lake City; Mayo Clinic, Phoenix; Novartis Pharmaceuticals Corporation, East Hanover; University of California, San Francisco.
The US92 study determined whether, in de novo renal transplant patients, concentration-controlled everolimus (EVR) with reduced dose tacrolimus (RTAC) is non-inferior compared to CellCept®, (mycophenolate…
2016 American Transplant Congress
Endoscopic Polydimethylsiloxane Injection in Prevention of Recurrent Graft Pyelonephritis for Transplanted Kidney with Vesicoureteral Reflux.
L. Nison,¹ M. Hazzan,² P. Puech,³ S. Bouye.¹
¹Urology, University of Lille, Lille, France; ²Nephrology, University of Lille, Lille, France; ³Radiology, University of Lille, Lille, France.
Reccurent acute graft pyelonephritis (AGPN) with vesicoureteral reflux (GVUR) can have a deleterious impact on graft outcome. The objective of this study was to evaluate…
2016 American Transplant Congress
Serum Albumin Level Has Association with Both Graft Failure and Mortality in Kidney Transplant Recipients.
H. Jeon,¹ S. Rhee,¹ D. Shin,¹ J. Oh,¹ Y. Kim,² J. Lee.³
¹Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Republic of Korea; ²Department of Surgery, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Republic of Korea; ³Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
Background: The studies concerned the association between post-transplant serum albumin concentration and post-transplant outcomes in kidney transplant recipients (KTRs) are scarce.Methods: To evaluate the impact…
2016 American Transplant Congress
Association Between GFR Decline and Long Term Outcome in Renal Transplantation.
A. Delay,¹ O. Moranne,² N. Maillard,¹ E. Alamartine,¹ C. Mariat.¹
¹Nephrology Department, CHU, Saint Etienne, France; ²Nephrology Department, CHU, Nimes, France.
In renal transplantation, GFR decline is strongly associated to graft failure and patient death and thus could be an interesting proxy for clinical research. GFR…
2016 American Transplant Congress
Treg-Rich Organized Lymphoid Structures (TOLS) in Spontaneously Accepted Mouse Kidney Allografts.
C. Yang,¹ E. Farkash,² D. Ndishabandi,¹ R. White,¹ B. Jiang,¹ I. Aljabban,¹ P. Russell,¹ J. Madsen,¹ R. Colvin,¹ A. Alessandrini.¹
¹Center for Transplantation Sciences, Dept. of Surgery, Dept. of Pathology, Massachusetts General Hospital, Boston, MA; ²University of Michigan School of Medicine, Ann Arbor, MI.
Background: In many MHC mismatched strain combinations (e.g., DBA/2 to B6) kidney allografts are spontaneously accepted without immunosuppression. This tolerance is regulatory, initially dependent Foxp3+…