Date: Saturday, June 11, 2016
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Halls C&D
Background: The studies concerned the association between post-transplant serum albumin concentration and post-transplant outcomes in kidney transplant recipients (KTRs) are scarce.
Methods: To evaluate the impact of serum albumin level on graft and patient survival, we performed a retrospective multi-center cohort study. A total of 2815 KTRs who underwent renal transplantation from Jan 1997 to Jan 2012 were classified into two groups according to the level of serum albumin at 1 year after transplantation (higher albumin group, ≥4.0 g/dL, n=1978 vs. lower albumin group, <4.0 g/dL, n=837). The Cox proportional hazard model was adjusted with age and gender of recipient, donor type, age of donor, diabetes mellitus, and estimated glomerular filtration rate (eGFR) at 1 year after transplantation.
Results: The mean age of the recipients was 41.7±11.3 (range, 18-73) years, and 59.1% were male. The rate of graft failure was higher in lower albumin group compared to higher albumin group (Hazard ratio [HR] 1.840, 95% confidence interval [CI] 1.367-2.477, P<0.001), even though eGFR at 1 year after transplantation was not different between the two groups (61.7±19.8 vs. 62.1±15.8 mL/min, P=0.615). Both all-cause mortality and non-cardiovascular mortality rates were higher in lower albumin group (HR 2.227, 95% CI 1.258-3.943, P=0.006, and HR 2.784, 95% CI 1.254-6.179, P=0.012, respectively). Every 1.0 g/dL higher serum albumin concentration was associated with 69.2% lower all-cause mortality (HR 0.308, 95% CI 0.196-0.483, P<0.001).
Conclusion: Serum albumin level at 1 year after transplantation is a prognostic factor for graft failure and patients' mortality in KTRs. Therefore, evaluation and management for hypoalbuminemia should be considered to improve outcomes in KTRs.
CITATION INFORMATION: Jeon H, Rhee S, Shin D, Oh J, Kim Y, Lee J. Serum Albumin Level Has Association with Both Graft Failure and Mortality in Kidney Transplant Recipients. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:Jeon H, Rhee S, Shin D, Oh J, Kim Y, Lee J. Serum Albumin Level Has Association with Both Graft Failure and Mortality in Kidney Transplant Recipients. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/serum-albumin-level-has-association-with-both-graft-failure-and-mortality-in-kidney-transplant-recipients/. Accessed September 21, 2020.
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