Articles tagged "Kidney transplantation"

2016 American Transplant Congress
Everolimus with Low-Dose Tacrolimus vs. a Standard Immunosuppressive Regimen: Renal Histology at 6 Months in De Novo Renal Transplant Patients.
S. Yilmaz,¹ D. Shaffer,² F. Shihab,³ K. McCague,⁴ D. Patel,⁴ Y. Qazi,⁵ F. Vincenti.⁶
¹University of Calgary, Calgary, AB, Canada; ²Vanderbilt University, Nashville, TN; ³University of Utah, Salt Lake City, UT; ⁴Novartis Pharmaceuticals Corporation, East Hanover, NJ; ⁵University of Southern California, Los Angeles, CA; ⁶University of California San Francisco, San Francisco, CA.
Morphologic changes in transplant protocol biopsies provide early evidence of renal damage. This study examined the renal histology of de novo patients 6 months post…
2016 American Transplant Congress
Defective Post-Reperfusion Metabolic Recovery Directly Associates with Incident Delayed Graft Function.
L. Wijermars, A. Schaapherder, J. Lindeman.
Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.
Delayed graft function (DGF) following kidney transplantation detrimentally affects long-term graft function and survival. DGF is a manifestation of ischemia reperfusion (I/R) injury, yet up…
2016 American Transplant Congress
Pre-Transplant Bariatric Surgery and One-Year Graft Loss Risk in Kidney Transplants.
G. Mour, J. Zhang, Z. Su, D. Taber, P. Mauldin, T. Srinivas.
MUSC, Charleston.
Background: Several centers recommend bariatric surgery (BS) pre-transplantation (pre-Tx) with arbitrary BMI cutoffs. The effects of BS on Tx outcome are unclear. We studied the…
2016 American Transplant Congress
Early Alloantibody Responses Against Donor MHC Class I and Class II Molecules Are Differentially Affected by Prolonged Cold Ischemia Storage of Renal Allografts.
V. Gorbacheva, R. Fan, W. Baldwin, A. Valujskikh.
Immunology, Cleveland Clinic Foundation, Cleveland, OH.
Prolonged cold ischemia storage (CIS) of donor transplants is a major risk factor for acute and chronic graft tissue injury. Despite strong clinical correlations between…
2016 American Transplant Congress
Mapping Heterogeneity in Antibody-Mediated Rejection Using Molecular Phenotypes and Archetype Analysis.
J. Reeve,¹ P. Halloran.^1,2
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada; ²Medicine, University of Alberta, Edmonton, AB, Canada.
Archetype analysis is a method for identifying new relationships among samples without subdividing them into classes, finding a limited number of archetypical cases and calculating…
2016 American Transplant Congress
A Molecular Biopsy Test for Probability of Non-Adherence.
P. Halloran,^1,3 G. Einecke,² J. Reeve.¹
¹ATAGC, Edmonton, AB, Canada; ²Hannover Medical School, Hannover, Germany; ³Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Afferent arteriolar hyalinosis (ah-score) in renal transplant biopsies increases with time of biopsy-post-transplant (TxBx), reflecting calcineurin inhibitor drug effects, donor aging, and progressive glomerular diseases.…
2016 American Transplant Congress
Association of Pre-Transplant Midodrine Use and Complications After Kidney Transplantation.
T. Alhamad,¹ D. Brennan,¹ Z. Brifkani,¹ H. Xiao,² M. Schnitzler,² V. Dharnidharka,¹ D. Axelrod,³ D. Segev,⁴ K. Lentine.²
¹Washington University, St. Louis; ²Saint Louis University, St. Louis; ³Dartmouth Hitchcock Medical Center, Hanover; ⁴Johns Hopkins University, Baltimore.
Background: Midodrine is increasingly prescribed to decrease the severity and complications of hypotension in dialysis patients. The impacts of midodrine use before kidney transplantation on…
2016 American Transplant Congress
Early Post Renal Transplant aHUS in Patients with Heterozygous CFHR3-CFHR1 Deletion.
S. Rhazouani, A. Malone, T. Alhamad, T. Maw, D. Brennan, R. Delos Santos.
Renal Division, Washington University, Saint Louis, MO.
Background: Atypical hemolytic uremic syndrome (aHUS) is a rare disease with a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Subjects homozygous for…
2016 American Transplant Congress
Significant Association of Vitamin-D Receptor (VDR) Gene Polymorphism and Incidence of De Novo DSA in Renal Transplantation.
L. Das, K. Ide, Y. Tanaka, N. Tanimine, S. Verma, H. Ohdan.
Department of Gastroenrological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Objective-Renal Transplantation (RT) is the optimal choice forend stage renal disease. Despite all advances in the development ofeffective immunosuppressive regimens in renal transplantation one of…
2016 American Transplant Congress
Detecting Renal Allograft Inflammation Using Quantitative Urine Metabolomics and CXCL10.
J. Ho,¹ A. Sharma,² R. Mandal,³ D. Wishart,³ C. Wiebe,¹ L. Storsley,¹ M. Karpinski,¹ I. Gibson,⁴ P. Nickerson,¹ D. Rush.¹
¹Internal Medicine, University of Manitoba, Winnipeg, MB, Canada; ²Pediatrics & Child Health, University of Manitoba, Winnipeg, MB, Canada; ³Biological Sciences, University of Alberta, Edmonton, AB, Canada; ⁴Pathology, University of Manitoba, Winnipeg, MB, Canada.
Background. We studied urine metabolomics (UM) alone or combined with urine CXCL10 to non-invasively detect cellular infiltrates in renal allograft biopsies.Methods. Urines (n=137) were obtained…