Articles tagged "Kidney transplantation"

2016 American Transplant Congress
Low Pretransplant BMI/Weight and Changes in Posttransplant T Cell Exhaustion Levels Are Associated with Viremia/Viral Infection in Pediatric Kidney Transplantation in the First Post-Transplant Year – A Report from the IMPACT Study Consortium.
R. Ettenger,¹ H. Chin,² P. Grimm,³ K. Kesler,² E. Reed,⁴ M. Sarwal,⁵ B. Warshaw,⁶ E. Tsai,¹ A. Kirk.⁷
¹Pediatrics, UCLA, LA, CA; ²Rho, Chappel Hill, NC; ³Pediatrics, Stanford Univ, Palo Alto, CA; ⁴Pathology, UCLA, LA, CA; ⁵Surgery, UCSF School of Medicien, SF, CA; ⁶Pediatric Nephrolgoy, Children's Healthcare of Atlanta, Atlanta, GA; ⁷Surgery, Duke University, Durham, NC.
Viral consequences of immunosuppression (IS) in pediatric(ped)kidney(kid)transplantation(Tx)patients(pts) are not fully known. We prospectively examined the immunologic and infectious (inf) history of 106 ped Tx pts…
2016 American Transplant Congress
Urinary CXCL9 Protein as Biomarker for BK Polyoma Viremia.
N. Sarabu,¹ R. El-Rifai,² J. Augustine,¹ A. Padiyar,¹ A. Huml,¹ T. Young,¹ V. Rodriguez,¹ D. Hricik.¹
¹Division of Nephrology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH; ²Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL.
Introduction: BK infection is common in kidney transplant patients and can result in accelerated loss of allografts. Management involves empiric lowering of immunosuppression, which can…
2016 American Transplant Congress
Clinical Measures to Reduce Early Urinary Tract Infections Following Kidney Transplantation: A Single Center Experience.
B. Chopra, T. Ko, C. Webster, J. Sheyman, A. Arumgarajah, V. Katragadda, R. Marcus, K. Sureshkumar.
Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA.
Urinary Tract infection (UTI) following kidney transplantation (KTx) is associated with increased morbidity. We implemented simple clinical measures in an attempt to reduce UTI incidence…
2016 American Transplant Congress
What if Mycophenolic Acid Product Is Discontinued Less Than 6 Weeks Before Pregnancy?
N. Sifontis,¹ L. Coscia,² D. Armenti,² S. Constantinescu,^2,3 M. Moritz.^2,4
¹Pharmacy Practice, Temple University, Philadelphia, PA; ²Gift of Life Institute, National Transplantation Pregnancy Registry (NTPR), Philadelphia, PA; ³Medicine, Temple University, Philadelphia, PA; ⁴Surgery, Lehigh Valley Health Network, Allentown, PA.
It is recommended that mycophenolic acid (MPA) products be discontinued at least 6 wks prior to conceiving due to potential teratogenic effects and increase risk…
2016 American Transplant Congress
Ischemia-Reperfusion Injury Following Transplantation: Implications for the Modulation of CXCL8 Chemokine Function.
B. Martinez Burgo,¹ S. Ali,¹ J. Kirby,¹ N. Sheerin,¹ S. Cobb,² D. Kashanin.³
¹Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom; ²Chemistry Department, Durham University, Durham, United Kingdom; ³Cellix Ltd., Dublin, Ireland.
Ischemia-Reperfusion Injury (IRI) is a major contributor to subsequent graft dysfunction. Chemokines play a key role in leukocyte recruitment towards to the injured tissue. CXCL8…
2016 American Transplant Congress
BK Polyomavirus Seroreactivity of Kidney Donors Predicts Viremia and Nephropathy in Recipients.
H. Wunderink,¹ E. van der Meijden,¹ C. van der Blij-de Brouwer,¹ M. Mallat,² G. Haasnoot,³ E. van Zwet,⁴ E. Claas,¹ J. de Fijter,³ A. Kroes,¹ F. Arnold,⁵ A. Touzé,⁵ F. Claas,³ J. Rotmans,³ M. Feltkamp.¹
¹Medical Microbiology, LUMC, Leiden, Netherlands; ²Nephrology, LUMC, Leiden, Netherlands; ³Immunohematology and Blood Transfusion, LUMC, Leiden, Netherlands; ⁴Medical Statistics and Bioinformatics, LUMC, Leiden, Netherlands; ⁵UMR INRA 1282 ISP, Université François Rabelais, Tours, France.
Background Kidney transplant (KTx) donors are not implicated in predicting BK polyomavirus (BKV) infection in the recipient. For BKV-associated nephropathy (BKVAN) however, donor origin of…
2016 American Transplant Congress
Pharmacist Impact on Medication Errors in a Chronic Kidney Transplant Clinic.
K. Covert,¹ C. Mardis,¹ J. Fleming,¹ A. Mardis,¹ H. Meadows,¹ N. Pilch,¹ P. Mohan,² M. Posadas,² M. Salazar,² T. Srinivas,² G. Mour,² D. Taber.¹
¹Pharmacy, The Medical University of South Carolina, Charleston, SC; ²Transplant Nephrology, The Medical University of South Carolina, Charleston, South Carolina.
Medication errors are associated with increased incidence of infection, rejection, and graft loss in kidney transplant recipients. This study aims to assess the impact of…
2016 American Transplant Congress
Validation of a Simplified Cost-Effective Clinical Risk Stratification That Predicts Myocardial Ischemic Events in Kidney Transplant Candidates.
T. Jiamjariyapon,^1,2 N. Townamchai,^2,3 N. Garg,² M. Pavlakis,² A. Chandraker.²
¹Bhumirajanagarindra Kidney Institute, Bangkok, Thailand; ²Division of Nephrology, Department of Medicine, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; ³Division of Nephrology, Chulalongkorn University, Bangkok, Thailand.
Background: Diagnosis of coronary artery disease before kidney transplantation is crucial in decreasing morbidity and mortality & avoiding the need for angiography in kidney transplant…
2016 American Transplant Congress
Early Conversion to Everolimus in De Novo Renal Transplant Recipients: Incidence of Viral Infections in the Randomized-Controlled ELEVATE Study.
H. Hirsch,¹ J. De Fijter,¹ M. van der Giet,¹ M. Zeier,¹ J. Pascual,¹ Y. Avihingsanon,¹ P. Lopez,² J. Aguilar-Sanchez,² J. Kochuparampil,² Z. Wang,³ H. Holdaas,¹ J. Cruzado.¹
¹ELEVATE Study Group, Basel, Switzerland; ²Novartis, Basel, Switzerland; ³Novartis Pharmaceutical Corporation, East Hanover.
BackgroundCytomegalovirus (CMV) and BK polyomavirus (BKPyV) infections are independent risk factors for acute rejection and graft loss. Early conversion from calcineurin inhibitors (CNIs) to everolimus…
2016 American Transplant Congress
Early Hospital Readmission Following Pediatric Kidney Transplantation.
E. King, L. Kucirka, M. McAdams-DeMarco, S. Bae, D. Segev.
Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD.
BACKGROUND: Approximately 31% of all adult kidney transplant (KT) recipients experience early hospital readmission and it is associated with inferior post-KT survival. Given the significant…