Articles tagged "Kidney transplantation"

2016 American Transplant Congress
Ischemia-Reperfusion Injury Following Transplantation: Implications for the Modulation of CXCL8 Chemokine Function.
B. Martinez Burgo,¹ S. Ali,¹ J. Kirby,¹ N. Sheerin,¹ S. Cobb,² D. Kashanin.³
¹Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom; ²Chemistry Department, Durham University, Durham, United Kingdom; ³Cellix Ltd., Dublin, Ireland.
Ischemia-Reperfusion Injury (IRI) is a major contributor to subsequent graft dysfunction. Chemokines play a key role in leukocyte recruitment towards to the injured tissue. CXCL8…
2016 American Transplant Congress
BK Polyomavirus Seroreactivity of Kidney Donors Predicts Viremia and Nephropathy in Recipients.
H. Wunderink,¹ E. van der Meijden,¹ C. van der Blij-de Brouwer,¹ M. Mallat,² G. Haasnoot,³ E. van Zwet,⁴ E. Claas,¹ J. de Fijter,³ A. Kroes,¹ F. Arnold,⁵ A. Touzé,⁵ F. Claas,³ J. Rotmans,³ M. Feltkamp.¹
¹Medical Microbiology, LUMC, Leiden, Netherlands; ²Nephrology, LUMC, Leiden, Netherlands; ³Immunohematology and Blood Transfusion, LUMC, Leiden, Netherlands; ⁴Medical Statistics and Bioinformatics, LUMC, Leiden, Netherlands; ⁵UMR INRA 1282 ISP, Université François Rabelais, Tours, France.
Background Kidney transplant (KTx) donors are not implicated in predicting BK polyomavirus (BKV) infection in the recipient. For BKV-associated nephropathy (BKVAN) however, donor origin of…
2016 American Transplant Congress
Pharmacist Impact on Medication Errors in a Chronic Kidney Transplant Clinic.
K. Covert,¹ C. Mardis,¹ J. Fleming,¹ A. Mardis,¹ H. Meadows,¹ N. Pilch,¹ P. Mohan,² M. Posadas,² M. Salazar,² T. Srinivas,² G. Mour,² D. Taber.¹
¹Pharmacy, The Medical University of South Carolina, Charleston, SC; ²Transplant Nephrology, The Medical University of South Carolina, Charleston, South Carolina.
Medication errors are associated with increased incidence of infection, rejection, and graft loss in kidney transplant recipients. This study aims to assess the impact of…
2016 American Transplant Congress
Validation of a Simplified Cost-Effective Clinical Risk Stratification That Predicts Myocardial Ischemic Events in Kidney Transplant Candidates.
T. Jiamjariyapon,^1,2 N. Townamchai,^2,3 N. Garg,² M. Pavlakis,² A. Chandraker.²
¹Bhumirajanagarindra Kidney Institute, Bangkok, Thailand; ²Division of Nephrology, Department of Medicine, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; ³Division of Nephrology, Chulalongkorn University, Bangkok, Thailand.
Background: Diagnosis of coronary artery disease before kidney transplantation is crucial in decreasing morbidity and mortality & avoiding the need for angiography in kidney transplant…
2016 American Transplant Congress
Early Conversion to Everolimus in De Novo Renal Transplant Recipients: Incidence of Viral Infections in the Randomized-Controlled ELEVATE Study.
H. Hirsch,¹ J. De Fijter,¹ M. van der Giet,¹ M. Zeier,¹ J. Pascual,¹ Y. Avihingsanon,¹ P. Lopez,² J. Aguilar-Sanchez,² J. Kochuparampil,² Z. Wang,³ H. Holdaas,¹ J. Cruzado.¹
¹ELEVATE Study Group, Basel, Switzerland; ²Novartis, Basel, Switzerland; ³Novartis Pharmaceutical Corporation, East Hanover.
BackgroundCytomegalovirus (CMV) and BK polyomavirus (BKPyV) infections are independent risk factors for acute rejection and graft loss. Early conversion from calcineurin inhibitors (CNIs) to everolimus…
2016 American Transplant Congress
Early Hospital Readmission Following Pediatric Kidney Transplantation.
E. King, L. Kucirka, M. McAdams-DeMarco, S. Bae, D. Segev.
Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD.
BACKGROUND: Approximately 31% of all adult kidney transplant (KT) recipients experience early hospital readmission and it is associated with inferior post-KT survival. Given the significant…
2016 American Transplant Congress
Mycophenolic Acid Product Discontinuation Prior to Conception: Analysis of Pregnancies in Kidney Transplant Recipients.
S. Constantinescu,^1,2 L. Coscia,² D. Armenti,² M. Moritz.^2,3
¹Medicine, Temple University, Philadelphia, PA; ²Gift of Life Institute, National Transplantation Pregnancy Registry (NTPR), Philadelphia, PA; ³Surgery, Lehigh Valley Health Network, Allentown, PA.
Mycophenolic acid (MPA) products are considered teratogenic and transplant centers report discontinuing MPA in female kidney recipients anticipating pregnancy. Data were collected by the National…
2016 American Transplant Congress
The Impact of Body Mass Index > 35 on Kidney Transplant Outcomes: A Systematic Review.
D. Walczak, E. Benedetti.
Organ Transplant, University of Illinois Hospital and Health Sciences System, Chicago, IL.
Background: The increased prevalence of obesity (BMI > 30) among adults in the United States over the last two decades is reflected in the number…
2016 American Transplant Congress
Understanding the Initial Rise in Kidney Discard Rates Observed Post-KAS.
D. Stewart,¹ A. Kucheryavaya,¹ R. Brown,¹ D. Klassen,¹ N. Turgeon,² M. Aeder.³
¹UNOS, Richmond, VA; ²Emory Univ, Atlanta, GA; ³Univ Hosp Case Med Ctr, Cleveland, OH.
Background: Kidney discard rates increased by 10% -- from 18.3% to 20.2% (p=0.001) -- during the first 7 months of KAS but returned to pre-KAS…
2016 American Transplant Congress
99% and 100% CPRA Patients Since KAS: A Substantial Increase in Transplants with Strong Evidence of a Bolus Effect.
A. Kucheryavaya,¹ M. Aeder,² N. Turgeon,³ D. Klassen,¹ D. Stewart.¹
¹UNOS, Richmond, VA; ²Univ Hosp Case Med Ctr, Cleveland, OH; ³Emory Univ Hosp, Atlanta, GA.
Background: The Kidney Allocation System (KAS), implemented on 12/4/14, increased allocation priority for candidates with CPRA of 99-100%. Analyses performed on behalf of the OPTN…