Articles tagged "Kidney transplantation"

2022 American Transplant Congress
Living Related Kidney Donation for Alport Syndrome Spectrum: Long-Term Outcomes
Y. Caliskan¹, A. B. Dirim², S. Safak², B. Yelken³, A. Velioglu⁴, A. Yildiz⁵, O. A. Oto², N. Guller², H. Yazici², A. Ersoy⁵, A. Turkmen³, K. L. Lentine¹
¹Saint Louis University, Saint Louis, MO, ²Istanbul University, Istanbul, Turkey, ³Koc University Hospital, Istanbul, Turkey, ⁴Marmara University, Istanbul, Turkey, ⁵Uludag University, Bursa, Turkey
*Purpose: Data to guide the evaluation of living related donor (LRD) candidates for kidney transplant recipients with Alport syndrome (AS) spectrum are limited. We examined…
2022 American Transplant Congress
Efficacy and Safety of PCSK-9 Inhibitor, Evolocumab for Lipid Management in Kidney Transplant Recipients
J. Pandav¹, R. Saranu¹, S. Muhsin¹, N. Murakami¹, S. Gabardi¹, K. Safa², A. Chandraker¹
¹Renal division, Brigham and Women's Hospital, Boston, MA, ²Renal division, Massachusetts General Hospital, Boston, MA
*Purpose: Dyslipidemia is common in kidney transplant recipients (KTRs). KDIGO guidelines suggest all KTRs should be treated with statins due to the high risk of…
2022 American Transplant Congress
Inferior Kidney Transplant Outcomes in Young Adults Transplanted as Children
K. Deville, F. Rosenblum, D. R. Kelly, M. Seifert
UAB School of Medicine, Birmingham, AL
*Purpose: Adolescence (age 13-17 years) has been identified as a high-risk age interval for pediatric kidney transplant recipients, with accelerated rates of late acute rejection…
2022 American Transplant Congress
Long Term Analysis of Pediatric En-Bloc Kidney Transplantation: A Single Center Experience
H. H. Patel¹, P. Di Cocco², J. Almario², A. Fratti², S. Akshelyan², E. Benedetti², I. Tzvetanov², M. Spaggiari²
¹University of Missouri-Kansas City School of Medicine, Kansas City, MO, ²University of Illinois at Chicago, Chicago, IL
*Purpose: Pediatric en-bloc kidney transplantations for adult recipients are uncommonly performed due to unique donor characteristics, the technical challenge of the operation, and potential surgical…
2022 American Transplant Congress
BiomarkeR Initiative to Advance Transplantation OutcomEs in Children (BRITE-c) Analysis
M. E. Seifert¹, L. Sheward², A. Kho², N. Rodig², V. Dharnidharka³, M. Diehl², R. B. Mannon⁴, O. Bestard⁵, T. Blydt-Hansen⁶, D. M. Briscoe²
¹University of Alabama, Birmingham, AL, ²Boston Children's Hospital, Boston, MA, ³St Louis Children's Hospital, St Louis, MO, ⁴University of Nebraska, Omaha, NE, ⁵Bellvitge University Hospital, Barcelona, Spain, ⁶BC Childrens, Vancouver, BC, Canada
*Purpose: Recent studies indicate that 25-36% of clinically stable pediatric renal transplant recipients will have subclinical rejection detected on surveillance biopsy. These findings highlight a…
2022 American Transplant Congress
Barriers and Facilitators to Care for Patients with Failed Kidney Transplants
A. Huml¹, K. Berg², A. Perzynski², C. Sullivan², A. Sehgal²
¹Department of Kidney Medicine, Cleveland Clinic, Cleveland, OH, ²Population Health Research Institute, The MetroHealth System, Cleveland, OH
*Purpose: To understand the barriers and facilitators to care for patients with failed kidney transplants from the perspective of providers.*Methods: Qualitative study employed focus groups…
2022 American Transplant Congress
First-in-Human Clinical-Grade Porcine Kidney Xenotransplant
J. E. Locke¹, B. Orandi¹, V. Kumar¹, J. Houp¹, D. Anderson¹, V. Hauptfeld¹, D. Martin², C. Killian¹, S. Macedon¹, N. Budd¹, K. Stegner¹, A. Dandro³, M. Kokkinaki³, K. Kuravi³, R. Reed⁴, H. Fatima¹, G. Baker¹, J. Perry¹, E. Bryant¹, M. Cheung¹, E. Erman¹, K. Kraebber¹, T. Gamblin¹, L. Guy¹, D. Ayares³, P. Porrett¹
¹University of Alabama at Birmingham, Birmingham, AL, ²Deakin University, Geelong, Australia, ³Revivicor, Incorporated, Blacksburg, VA, ⁴University of Alabama at Birmingham, Irondale, AL
*Purpose: Proof-of-concept xenotransplant work has been performed in pig to non-human primates (NHP), but it is unclear if outcomes can be recapitulated in humans. While…
2022 American Transplant Congress
Which is More Important for Predicting De Novo DSA Production, B Cell Epitope (EPLET) or T Cell Epitope (PIRCHE) Analysis ?
T. Kobayashi¹, T. Tomosugi², S. Sakamoto², S. Ashimine¹, K. Iwasaki¹, M. Niemann³, E. Spierings⁴, Y. Miwa¹, M. Okumura¹, K. Ishiyama¹, A. Takeda², N. Goto², S. Narumi², Y. Watarai²
¹Aichi Medical University School of Medicine, Nagakute, Japan, ²Nagoya Daini Red Cross Hospital, Nagoya, Japan, ³PIRCHE AG, Berlin, Germany, ⁴UMC Utrecht, Utrecht, Netherlands
*Purpose: De novo donor-specific antibodies (dnDSA) can cause chronic ABMR, resulting in poor prognosis. Recently, mismatch at B cell epitope level, i.e. EPLET mismatch, has…
2022 American Transplant Congress
A New Algorithm Combining Donor Derived Cell-Free DNA Fraction and Quantity to Detect Kidney Transplant Rejection Using Molecular Diagnoses and Histology
P. F. Halloran¹, J. Reeve¹, K. S. Madill-Thomsen¹, N. Kaur², E. Ahmed², N. Al Haj Baddar², Z. Demko², N. Liang², R. K. Swenerton², B. G. Zimmermann², P. Van Hummelen², A. Prewett², H. Tabriziani², P. Gauthier², P. R. Billings²
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²Natera, Inc., Austin, TX
*Purpose: Donor derived cell-free DNA (dd-cfDNA) has been shown to be associated with allograft rejection, both histological and molecular (JASN, in press). Clinically available dd-cfDNA…
2022 American Transplant Congress
Antibody-Mediated Rejections with C1q-binding and without C1-Binding Donor-Specific Antibodies in Kidney Transplantation
J. Jeon, C. Baek
Asan Medical Center, Seoul, Korea, Republic of
*Purpose: All donor-specific antibodies (DSAs) are not clinically relevant. Therefore, the C1q assay has been recently used, but its clinical meaning and usefulness should be…