Articles tagged "Kidney transplantation"

2022 American Transplant Congress
Everolimus Alleviates Renal Allograft Interstitial Fibrosis by Inhibiting Epithelial to Mesenchymal Transition Not Only via Inducing Autophagy but Also via Stabilizing iκB-α
Z. Gui¹, W. Zijie², M. Zheng³, M. Gu¹, R. Tan³
¹Department of Urology, The Second Affiliated Hospital with Nanjing Medical University, Nanjing, China, ²Jiangsu Province Hospital, Nanjing, China, ³Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China
*Purpose: Chronic allograft dysfunction (CAD) is the major cause of late graft loss in long-term renal transplantation. In our previous study, we found Epithelial-mesenchymal transition…
2022 American Transplant Congress
Wide Spectrum of Molecular Injury Highlights Heterogeneity of Banff Tubulitis and Interstitial Inflammation Lesions
M. J. Ellis¹, T. Maw², E. Huang³, E. Stites⁴, F. Shihab⁵, D. C. Brennan⁶, G. Shekhtman⁷, N. Agrawal⁷, J. Zeng⁷, S. Kung⁸
¹Duke University, Durham, NC, ²University of Southern California, Los Angeles, CA, ³Cedars-Sinai Medical Center, Los Angeles, CA, ⁴University of Colorado, Aurora, CO, ⁵University of Utah, Salt Lake City, UT, ⁶Johns Hopkins School of Medicine, Baltimore, MD, ⁷CareDx, Brisbane, CA, ⁸University of California, San Francisco, San Francisco, CA
*Purpose: The pathological definition and clinical significance of borderline T cell-mediated rejection (BL-TCMR) remains an area of active debate, leading to inconsistencies in therapeutic strategy.…
2022 American Transplant Congress
Use of Kidneys from Hepatitis C Nat Positive Donors for Uninfected Recipients: Early Results from a Rural Appalachian Kidney Transplant Program
B. Gillis¹, F. Afridi¹, R. Lopez¹, V. Chaudhary¹, D. Kannabhiran¹, C. Fagella¹, R. Zomak¹, K. Meyer¹, M. Thornberg¹, L. Biondi²
¹Department of Surgery, West Virginia University, Morgantown, WV, ²Department of Surgery, West Virginia University, Morgantown, WV, WV
*Purpose: Increasing mismatch between kidneys available for transplant and the number of patients on the transplant wait list has led to research into novel sources…
2022 American Transplant Congress
Revolutionizing Clinical Diagnostic Models for Acute Rejection Using Generative Adversarial Networks
W. Yazar¹, R. Nijor¹, R. Sarwal¹, N. Titzler¹, M. Sarwal², S. Ghosh¹
¹Nephrosant, Brisbane, CA, ²NephroSant, Brisbane, CA
*Purpose: Data heterogeneity, incompleteness and class-imbalance, hallmarks of real world healthcare data (RWHD), pose long-standing challenges to the accuracy of AI-based models. This research evaluates…
2022 American Transplant Congress
Clinical Significance of Chronic Active T-cell Mediated Rejection in Renal Transplant Biopsies
C. T. Chung¹, A. Han², H. Kim³, S. Min², J. Ha²
¹Department of Surgery, Inha University Hospital, Incheon, Korea, Republic of, ²Seoul National University College of Medicine, Seoul, Korea, Republic of, ³Department of Surgery, Korea University Guro Hospital, Seoul, Korea, Republic of
*Purpose: Chronic active T-cell mediated rejection (CATCMR) was newly added to the Banff classification in 2017. Currently, its response to treatment, natural course, clinical significance…
2022 American Transplant Congress
A Hybrid Model Combining Survival Analysis, Knapsack Optimization and Supervised Learning to Extrapolate the Evolution of Kidney Transplantation Patients from Donors with Expanded Criteria After Controlled Circulatory Death
F. Santos Arteaga¹, D. Di Caprio², O. Bestard³, N. Montero⁴, F. Moreso³, M. Crespo⁵, C. Facundo⁶, J. Reinoso-Moreno⁷, D. Cucchiari⁷, B. Bayes⁷, E. Poch⁷, J. M. Campistol⁷, F. Oppenheimer⁷, F. Diekmann⁷, I. Revuelta⁷
¹Faculty of Economics and Management, Universidad Complutense de Madrid, Madrid, Spain, ²Department of Economics and Management, University of Trento, Trento, Italy, ³Department of Nephrology and Kidney Transplant, Hospital Universitari Vall Hebrón, Barcelona, Spain, ⁴Department of Nephrology and Kidney Transplant, Hospital Universitari de Bellvitge, Barcelona, Spain, ⁵Department of Nephrology and Kidney Transplant, Hospital del Mar, Barcelona, Spain, ⁶Department of Nephrology and Kidney Transplant, Fundació Puigvert, Barcelona, Spain, ⁷Department of Nephrology and Kidney Transplant, Hospital Clinic, Barcelona, Spain
*Purpose: Kidney transplantation (KT) with expanded criteria donors (ECD) after controlled circulatory death (cDCD) in high-risk patients is being debated. We categorize patients via a…
2022 American Transplant Congress
Successful Implementation of a Rural Appalachian Kidney Transplant Program; One Year Outcomes
F. Afridi¹, B. Gillis¹, R. Lopez¹, D. Kannabhiran¹, V. Chaudhary¹, M. Thornberg¹, R. Zomak¹, K. Meyer¹, C. Newman¹, L. Biondi²
¹Department of Surgery, West Virginia University, Morgantown, WV, ²Department of Surgery, West Virginia University, Morgantown, WV, WV
*Purpose: Kidney transplantation has become the optimal treatment for end stage renal disease (ESRD), allowing dialysis free survival. Despite widespread availability of transplant programs; rural…
2022 American Transplant Congress
Impact of the Second Year COVID-19 Pandemic on the U.S. Kidney Transplantation: Interrupted Time Series Analysis
E. Tantisattamo¹, N. Polpichai², P. Mutirangura³, M. Tanariyakul⁴
¹Division of Nephrology, Hypertension and Kidney Transplantation, Department of Medicine, University of California Irvine School of Medicine, Orange, CA, ²Faculty of Medicine Songklanagarin Hospital, Prince of Songkla University, Songkhla, Thailand, ³Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, ⁴Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
*Purpose: The number of kidney transplant (KT) was decreased since the COVID-19 pandemic; however, the magnitude of the pandemic on the number of U.S. KT…
2022 American Transplant Congress
Plasma Donor-Derived Cell-Free DNA Longitudinal Kinetics After Kidney Transplantation in Children
R. Dandamudi¹, S. Federman², R. Woodward², S. Dholakia², L. Walther¹, V. Dharnidharka¹
¹Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO, ²CareDx, Brisbane, CA
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) are DNA fragments released continuously into circulation from injured donor allograft cells. In adult studies, the levels drop to a…
2022 American Transplant Congress
Long-Term Kidney Allotransplant Acceptance is Defined by a Shift from a T Cell to a B Cell Rich Immune Microenvironment Within the Graft
E. S. Szuter¹, T. Yokose¹, M. T. Guinn¹, J. Ge², I. Rosales³, B. Kwon⁴, P. S. Russell¹, A. Cuenca², D. Kreisel⁵, P. Sage⁶, J. C. Madsen¹, R. B. Colvin³, A. Alessandrini¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Surgery, Boston Children's Hospital, Boston, MA, ³Department of Pathology, Massachusetts General Hospital, Boston, MA, ⁴Harvard College, Cambridge, MA, ⁵Department of Surgery, Washington University, St. Louis, MO, ⁶Transplantation Research Center, Renal Division, Brigham and Women’s Hospital, Boston, MA
*Purpose: Mouse kidney allografts are spontaneously accepted in select, fully-mismatched donor-recipient strain combinations, such as DBA/2J to C57BL/6 (B6). Tolerant renal grafts develop aggregates of…