ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Kidney transplantation"

  • 2017 American Transplant Congress

    Overweight Kidney Transplant Recipients Are at Risk of Being Overdosed Following Standard Bodyweight-Based Tacrolimus Dosing.

    D. Hesselink,1 L. Andrews,2 B. de Winter,2 J. Tang,3 N. Shuker,2 R. Bouamar,2 R. van Schaik,4 B. Koch,2 T. Van Gelder.1

    1Internal Medicine, Erasmus MC, Rotterdam, Netherlands; 2Hospital Pharmacy, Erasmus MC, Rotterdam, Netherlands; 3Laboratory Medicine, West China Hospital of Sichuan University, Chengdu, China; 4Clinical Chemistry, Erasmus MC, Rotterdam, Netherlands

    Bodyweight-based dosing of tacrolimus (Tac) is considered standard care, even though the available evidence is thin. An increasing proportion of transplant recipients is overweight, prompting…
  • 2017 American Transplant Congress

    Pre-Transplant Panel Reactive T Cells (PRT) with IL-15 as a Risk-Stratifier of Acute Rejection in Kidney Transplant Patients on Belatacept Therapy.

    P. Cravedi,1 I. Gandolfini,1 C. Donadei,1 R. Fairchild,2 K. Newell,3 R. Mannon,4 P. Heeger,1 CTOT16 Consortium.

    1Dept of Medicine, Icahn School of Medicine at Mount Sinai, New York; 2Dept of Immunology, Cleveland Clinic, Cleveland; 3Dept of Surgery, Emory University, Atlanta; 4Renal Division, UAB, Birmingham

    While kidney transplant recipients treated with bela without calcineurin inhibitors (CNI) have better 5-10y eGFR versus those on CNI, Belatacept (bela) use is associated with…
  • 2017 American Transplant Congress

    Obesity Is an Important Factor in Deceased but Not Living Donor Kidney Transplants.

    A. Asderakis, A. Ilham, U. Khalid, R. Chavez.

    Cardiff Transplant Unit, University Hospital of Wales, Cardiff, United Kingdom

    Introduction There is an increasing obesity among potential kidney transplant recipients. We had in the past shown that obesity did increase the wound infection rate,…
  • 2017 American Transplant Congress

    Single Kidney Transplantation from Pediatric Donors Younger Than 3 Years to Adult Recipients.

    L. Zhu, B. Liu, S. Chang, D. Du, N. Gong, J. Jiang, Z. Chen, G. Chen.

    Tongji Hospital,Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    Background: Traditionally, the criteria of splitting pediatric en bloc kidneys for transplantation into two adults includes: donor age > 3 years, donor weight > 12kg,…
  • 2017 American Transplant Congress

    Comparison of the Estimated and Measured Glomerular Filtration Rate in Kidney Donor Candidates.

    C. Akhimiona, W. Suki, D. Nguyen, E. Graviss.

    Nephrology, Houston Methodist Hospital, Houston, TX

    Background and objectivesThe assessment of GFR in kidney donor candidates is necessary for the appropriate allocation of donor kidneys to recipients. This assessment can be…
  • 2017 American Transplant Congress

    Prospective Monitoring of 25-Hydroxyvitamin Vitamin D Levels After Kidney Transplantation and Its Associations with Clinical Outcomes.

    P. Bedi, N. Hayde, L. Kamal, M. Ajaimy, M. Lubetzky, G. de Boccardo, E. Akalin.

    Montefiore Transplant Center, Albert Einstein College of Medicine, Bronx, NY

    Background: Kidney transplant recipients usually have low vitamin D levels. Vitamin D deficiency is recognized as a risk factor for progression of kidney disease in…
  • 2017 American Transplant Congress

    Kidney Waitlist Management: The Readiness Model of Predicting Transplants Under the Kidney Allocation System.

    N. Elias, B. Kimball, L. Walsh, D. Wojciechowski, J. Markmann, E. Heher.

    Transplant Center, Massachusetts General Hospital, Boston, MA

    Based on the Organ Procurement and Transplantation Network data, between 2001 and 2016 the national kidney wait-list has grown from 51,271 to 100,791 (97%). At…
  • 2017 American Transplant Congress

    Transplanting Hepatitis C Kidneys into Negative KidnEy Recipients [THINKER] Trial.

    D. Goldberg, E. Blumberg, R. Reddy, S. Nazarian, V. Van Deerlin, J. Trofe-Clarke, M. Levine, D. Sawinski, R. Bloom, P. Abt, P. Reese.

    University of Pennsylvania, Philadelphia

    Background: More than 500 kidneys from HCV+ deceased donors are discarded each year, even though direct acting antiviral therapies have cure rates exceeding 95%. We…
  • 2017 American Transplant Congress

    Blood Transfusion Induced Donor Specific Antibodies Are Associated with Rejection and Graft Failure.

    S. Hassan,1 F. Regan,2,3 C. Brown,4 A. Harmer,3 N. Anderson,3 P. Brookes,5 D. Taube,1 M. Willicombe.1

    1Renal and Transplant Centre, Imperial College Healthcare NHS Trust, London, United Kingdom; 2Haematology, Imperial College Healthcare NHS Trust, London, United Kingdom; 3NHS Blood and Transplant, London, United Kingdom; 4Histocompatibility and Immunogenetics, NHS Blood and Transplant, London, United Kingdom; 5Histocompatibility and Immunogenetics, Imperial College Healthcare NHS Trust, London, United Kingdom

    Introduction: Although it is well known that blood transfusions post-transplant are associated with the development of both HLA and donor specific antibodies [DSAs] and a…
  • 2017 American Transplant Congress

    Impact of Antihypertensive (AHT) Choice and Advagraf® Dose on Immunologic Events in Renal Allografts 24 Months Post-Transplantation (Tx).

    D. Rush,1 S. Cockfield,2 S. Wilson,3 J. Howell,4 FKC-014 Study Group.

    1Health Sciences Centre, Winnipeg, MB, Canada; 2University of Alberta Hospital, Edmonton, AB, Canada; 3Astellas Pharma Global Development, Northbrook, IL; 4Astellas Pharma Global Development, Markham, ON, Canada

    Renal allograft inflammation may be modulated by ACEi- or ARB-type AHTs (renin-angiotensin system (RAS)-targeting drugs that may inhibit calcineurin) or by optimizing tacrolimus (TAC) exposure.…
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