Date: Tuesday, May 2, 2017
Session Name: Poster Session D: Living Donor Kidney Transplant II
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
Background and objectives
The assessment of GFR in kidney donor candidates is necessary for the appropriate allocation of donor kidneys to recipients. This assessment can be done using an estimated GFR (eGFR) or a measured GFR (mGFR).
In our center, kidney function is assessed by mGFR, typically determined by radio-isotopic iothalamate clearance, or by 24-hour urine creatinine clearance. For comparison, the CKD-EPI equation was utilized in this study to calculate eGFR, to test its reliability in assessing kidney function in healthy individuals. In addition to testing the performance of the CKD-EPI equation in correctly estimating the GFR, as compared to the mGFR by iothalamate clearance and 24-hour urine creatinine clearance, we also examined additional risk factors in association to the GFR.
Design, setting, participants and measurement
This was a retrospective chart review that analyzed data on 243 kidney donor candidates at our center from January 2013 to March 2016. The eGFR bias, precision and accuracy were assessed. Interactions of age, gender, race, and BMI with eGFR relative the mGFR were also determined.
The median mGFR was 109ml/min/1.73m2. eGFR underestimated mGFR by 14.9% (percentage of eGFR within 30% of mGFR of 88.9%). We further divided the patients into CKD groups: GFR≥90 (G1) and GFR<90 (G2). The eGFR underestimated the mGFR by 16.3% in G1 (percentage of estimates within 30% of mGFR of 88.6%) and by 1.4% in G2 (percentage of estimates within 30% of GFR of 91.3%) respectively.
Increased age and BMI ≥30 were associated with a decrease in mGFR vs. eGFR, while the male gender and the black race were associated with increased eGFR vs mGFR.
The eGFR CKD-EPI underestimates the mGFR, but achieves a degree of accuracy that can possibly allow for its substitution in determining donor renal function. The eGFR also best estimates the mGFR in donors with mGFR<90.
CITATION INFORMATION: Akhimiona C, Suki W, Nguyen D, Graviss E. Comparison of the Estimated and Measured Glomerular Filtration Rate in Kidney Donor Candidates. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:Akhimiona C, Suki W, Nguyen D, Graviss E. Comparison of the Estimated and Measured Glomerular Filtration Rate in Kidney Donor Candidates. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/comparison-of-the-estimated-and-measured-glomerular-filtration-rate-in-kidney-donor-candidates/. Accessed August 14, 2020.
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