Articles tagged "Kidney transplantation"

2017 American Transplant Congress
Mycophenolate Dose Reductions Are Not Associated with De Novo Donor-Specific Antibodies.
S. Davis, J. Gralla, P. Klem, A. Wiseman, J. Cooper.
University of Colorado, Aurora, CO
De novo donor-specific antibodies (dnDSA) are central to the development of antibody-mediated rejection, which is the most important cause of death-censored graft loss. It is…
2017 American Transplant Congress
Program-Specific Offer Acceptance Behavior for Kidney Programs Across the Spectrum of KDPI.
A. Wey, N. Salkowski, B. Kasiske, A. Israni, J. Snyder.
Scientific Registry of Transplant Recipients, Minneapolis, MN
Little is known about the offer acceptance behavior of kidney transplant programs, which affects rates of discard and access to transplant. An offer acceptance model…
2017 American Transplant Congress
Estimating Donor Organ Quality with Baseline Histology and Kidney Donor Risk Index for Predicting Graft Outcomes in Deceased Donor Kidney Transplantation.
K. Park,¹ S. Park,² H. Park,² J. Park,¹ H. Chung,¹ M. Kim,³ H. Cho,² J. Lee.¹
¹Internal Medicine, Ulsan University Hospital, Ulsan, Republic of Korea; ²Surgery, Ulsan University Hospital, Ulsan, Republic of Korea; ³Pathology, Ulsan University Hospital, Ulsan, Republic of Korea
Background: Donor organ quality is a key determinant of graft outcomes in deceased donor kidney transplantation (DDKT). The effect of baseline histology at the time…
2017 American Transplant Congress
Novel Therapies for Diabetic Kidney Disease.
M. Nguyen, K. Kodama, M. Sarwal.
University of California, San Francisco, San Francisco, CA
Introduction: The development and progression of diabetic kidney disease (DKD) is thought to involve a combination of hemodynamic, metabolic, ischemic, and inflammatory factors; however, the…
2017 American Transplant Congress
The Impact of Elevated Doppler Resistive Indices in Renal Transplant Recipients with Delayed Graft Function.
D. Mikhail,¹ E. Chan,² G. Aboalsamh,³ S. Cruise,⁴ S. Aquil,³ M. Mohamed,³ A. Sener,^1,3 P. Luke.^1,3
¹Urology, Western University, London, ON, Canada; ²Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; ³Multi-Organ Transplant Program, Western University, London, ON, Canada; ⁴Family Medicine, Schulich School of Medicine and Dentistry, London, ON, Canada
INTRODUCTION AND OBJECTIVES: Doppler Ultrasonography is often carried out to determine renal allograft perfusion in the early post-operative period. An elevated resistive index (RI) is…
2017 American Transplant Congress
Depressive Symptoms, Physical Frailty, and Kidney Transplant Adverse Outcomes.
J. Konel, F. Warsame, H. Ying, C. Haugen, M. McAdams DeMarco, D. Segev.
Johns Hopkins, Baltimore, MD
Depression is the most prevalent mental health illness in ESRD patients. Physical frailty, a measure of physiologic reserve, is associated with depressive symptoms. They are…
2017 American Transplant Congress
Donor Kidney Volume Predicts One and Three Month eGFR in Live Donor Kidney Transplant Recipients.
D. Al-Adra,¹ M. Lambadaris,² A. Barbas,¹ Y. Li,² N. Goldaracena,¹ O. Famure,² S. Kim,² A. Ghanekar.¹
¹Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ²Kidney Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada
IntroductionThere has been increasing interest in non-immunological factors that may impact long-term graft survival after kidney transplantation. It is hypothesized that transplantation of larger nephron…
2017 American Transplant Congress
Willingness of End-Stage Renal Disease Patients (ESRD) without Hepatitis C (HCV) to Accept a HCV+ Kidney.
P. Reese,¹ D. Goldberg,¹ A. Mussell,¹ M. McCauley,¹ D. Sawinski,¹ N. Molina,² R. Tomlin,² S. Doshi,¹ P. Abt,¹ E. Blumberg,¹ C. Thiessen,² S. Kulkarni,² G. Esnaola.²
¹UPENN, Philadelphia, PA; ²Yale, New Haven, CT
Background: New HCV drugs could reduce the risks of donor-derived HCV infection. However, it is unknown if HCV-negative (HCV-) ESRD patients would accept an HCV+…
2017 American Transplant Congress
Two Promoter Polymorphisms in the Genes Encoding for Complement Regulating Proteins CD46 and CD59 in Kidney Donors Are Associated with Biopsy Proven Acute Rejection.
L. Michielsen,¹ A. van Zuilen,¹ T. Kardol-Hoefnagel,² M. Verhaar,¹ H. Otten.²
¹Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, Netherlands; ²Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
BackgroundComplement regulating proteins, including CD46, CD55 and CD59, protect cells against self-damage. Because of their expression on the donor endothelium, they are hypothesized to be…
2017 American Transplant Congress
Preformed HLA Donor-Specific Antibodies Disappearance After Kidney Transplantation: Significance and Comparison with Persistent DSA.
D. Redondo,¹ M. Pérez-Sáez,¹ M. Mir,¹ J. Gimeno,¹ C. García,² J. Hernández,² J. Yélamos,³ J. Pascual,¹ M. Crespo.¹
¹Nephrology Department, Hospital del Mar, Barcelona, Spain; ²Laboratori de Referència de Catalunya, Barcelona, Spain; ³IMIM, Barcelona, Spain
The presence of donor-specific antibodies (DSA) increase the risk of antibody-mediated rejection (ABMR) and graft failure in kidney transplant recipients (KTR). We aimed to analyze…