Articles tagged "Kidney transplantation"

2017 American Transplant Congress
Tacrolimus Dose Variability, CYP3A5 Genotype, and Acute Rejection in African American and European American Kidney Transplant Recipients.
S. Seibert,¹ D. Schladt,² B. Wu,³ W. Guan,³ C. Dorr,^2,7 D. Berglund,¹ R. Remmel,⁴ A. Matas,⁵ R. Mannon,⁶ A. Israni,^2,7 W. Oetting,¹ P. Jacobson,¹ For the DeKAF Genomics Investigators.
¹Dept of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota (UMN), Mpls, MN; ²Chronic Disease Research Group, Minneapolis Medical Research Foundation, Mpls, MN; ³Division of Biostatistics, School of Public Health, UMN, Mpls, MN; ⁴Dept of Medicinal Chemistry, College of Pharmacy, UMN, Mpls, MN; ⁵Division of Transplantation, Dept of Surgery, School of Medicine, UMN, Mpls, MN; ⁶Dept of Nephrology, University of Alabama, Birmingham, AL; ⁷Dept of Nephrology, Hennepin County Medical Center, School of Medicine, UMN, Mpls, MN
Background: Poor immunosuppression with tacrolimus (TAC) after kidney transplantation contributes to the development of toxicity and loss of efficacy. We aimed to associate intra-patient TAC…
2017 American Transplant Congress
Optimization of Extended-Release Tacrolimus Dose with Mycophenolate Mofetile Based Immunosuppression in De Novo Kidney Transplant Recipients: 2 Years Outcome.
Y. Watarai,¹ S. Narumi,¹ M. Okada,¹ R. Kimura,¹ K. Hatazoe,¹ K. Futamura,¹ T. Yamamoto,¹ T. Hiramitsu,¹ M. Tsujita,¹ N. Goto,¹ T. Kobayashi.²
¹Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Aichi, Japan; ²Kidney Transplant Surgery, Aichi Medical University, Nagakute, Aichi, Japan
Purpose: Once-daily tacrolimus extended-release formulation (TACER) has been accepted in kidney transplantation, however its optimal dosing are not well determined. We have validated the institutional…
2017 American Transplant Congress
Influence of Tacrolimus Metabolism Rate on Patients' Survival After Renal Transplantation.
G. Thölking, J. Steinke, K. Schuette-Nuetgen, H. Pavenstädt, B. Suwelack, S. Reuter.
Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Münster, Münster, Germany
Introduction: Tacrolimus (Tac) is an integral part of the immunosuppressive regimen after renal transplantation (RTx). A fast Tac metabolism rate defined as the Tac blood…
2017 American Transplant Congress
Cyclosporine Effects on Blood Pressure Are Exaggerated in Pubertal Girls After Renal Transplantation.
A. Melk,¹ R. Sugianto,¹ B. Schmidt,² K. Krupka,³ B. Höcker,³ B. Tönshoff,³ E. Wühl.³
¹Pediatric Nephrology, Hannover Medical School, Hanover, Germany; ²Nephrology, Hannover Medical School, Hanover, Germany; ³Pediatric Nephrology, University of Heidelberg, Heidelberg, Germany
Hypertension is a common problem after renal transplantation. We investigated potential contributing factors for high blood pressure (BP) in 336 pediatric transplant recipients from the…
2017 American Transplant Congress
The Effects of Aspirin on Major Adverse Cardiac Events and Kidney Allograft Outcomes: A Meta-Analysis.
W. Cheungpasitporn, C. Thongprayoon, D. Mitema, M. Mao, W. Kittanamongkolchai, M. Gonzalez-Suarez, S. Erickson.
Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN
BACKGROUND: The use of aspirin in chronic kidney disease patients has been shown to reduce myocardial infarction but may increase major bleeding. However, its effects…
2017 American Transplant Congress
Small Pediatric Donor Kidney Transplantation in Pediatric Recipients.
H. Yaffe,^1,2 P. Friedmann,² L. Kayler.³
¹Surgery, Montefiore Medical Center, Bronx, NY; ²Surgery, Albert Einstein College of Medicine, Bronx, NY; ³Surgery, Erie County Medical Center, Buffalo, NY
Kidneys from small pediatric donors (age <5 years, weight <21 kg) may be a means to increase the donor pool for pediatric recipients. Transplantation of…
2017 American Transplant Congress
A Retrospective Study on the Impact of Abdominal Surgical Histories on Hand-Assisted Laparoscopic Donor Nephrectomy for Living Donor Adult Kidney Transplant.
T. Hiramitsu, K. Futamura, M. Okada, M. Tsujita, N. Goto, S. Narumi, Y. Watarai.
Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Aichi, Japan
Background This study investigated the impact of hand-assisted laparoscopic donor nephrectomy (HALDN) for living donors with surgical histories.Methods During January 2009–May 2015, 555 living kidney…
2017 American Transplant Congress
Metabolomics Study for Identification of Potential Biomarkers of Long-Term Survival in Kidney Transplantation Recipients.
C.-D. Kim, H.-Y. Jung, R.-H. Kim, S.-M. Park, J.-H. Park, K.-H. Lee, E.-S. Lee, K.-Y. Kim, J.-Y. Choi, J.-H. Cho, S.-H. Park, Y.-L. Kim.
Division of Nephrology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea
Background: The development of new strategies to improve long-term survival outcome after kidney transplantation is also becoming important. Although current diagnosis of allograft dysfunction relies…
2017 American Transplant Congress
Pre-Kidney Transplant Lower Extremity Impairment and Post-Transplant Mortality.
A. Nastasi,^1,2 M. McAdams-DeMarco,^1,2 J. Schrack,¹ H. Ying,² C. Haugen,² M. González Fernández,³ D. Segev.^1,2
¹Epidemiology, Johns Hopkins University, Baltimore, MD; ²Surgery, Johns Hopkins University, Baltimore, MD; ³Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD
INTRODUCTION. Few objective tests can be easily performed prior to kidney transplantation (KT) to effectively stratify patients by risk of post-KT mortality. The short physical…
2017 American Transplant Congress
Dual Targeting with Carfilzomib and Tocilizumab Abrogates Antibody-Mediated Rejection and Prolongs Survival in a Highly Sensitized Rhesus Model of Kidney Transplantation.
B. Ezekian, J. Kwun, M. Manook, K. Freischlag, V. Curfman, E. Branum, J. Park, J. Yi, S. Jordan, S. Knechtle.
Duke University Medical Center, Durham, NC; Cedars-Sinai Medical Center, Los Angeles, CA
Purpose:Sensitized recipients have poor access to kidney transplantation (KT) and worse outcomes when transplanted. We have shown that bortezomib inhibits plasma cells (PCs), but does…