2017 American Transplant Congress
Effect of Everolimus-Based Immunosuppressive Regimen on New Onset of Diabetes After Kidney Transplantation – A 24 Month Subanalysis from the ELEVATE Study.
1ELEVATE Study Group, Oslo, Norway; 2Novartis Pharma AG, Basel, Switzerland
Purpose: New onset diabetes after transplantation (NODAT) is a common metabolic complication which affects long-term patient survival and graft outcomes. Most of the immunosuppressive drugs…2017 American Transplant Congress
Relationship Between Mixed Chimerism and Tolerance in HLA-Matched and -Mismatched Recipients of Kidney and Hematopoietic Cell Transplants.
Twenty-eight fully HLA-matched and 18 HLA haplotype- matched recipients were given combined kidney and hematopoietic cell transplants using a completely post-transplant conditioning regimen consisting of…2017 American Transplant Congress
APOL1 Genotype Does Not Affect Donor Renal Function Post Live Kidney Donation.
Background: Apolipoprotein-L1 (APOL1) risk variants have emerged as a predictor of renal disease in individuals of African Ancestry (AA). The effect of APOL1 risk variants…2017 American Transplant Congress
Complement Activating Anti-HLA Antibodies: Identification of Specific Histo-Mmolecular Phenotype of Rejection for Complement-Targeting Therapy.
Addressing the heterogeneity of antibody-mediated allograft rejection by identifying phenotypes based on pathophysiology is critical for improving outcomes in transplantation. We investigated whether complement-binding anti-HLA…2017 American Transplant Congress
CD47 Blockade Reduces Ischemia/Reperfusion Injury in Donation After Cardiac Death Rat Kidney Transplantation.
Purpose: We evaluated the potential effects of antibody-mediated CD47 blockade to modulate vascular endothelial nitric oxide activity and reduce ischemia reperfusion injury in a rat…2017 American Transplant Congress
DNA Methylation Dynamics from Ischemia/Reperfusion Injury to Long-Term Allograft Function.
1Surgery, UVA, Charlottesville; 2VCU, Richmond; 3OSU, Columbus
Background: We hypothesize that following early graft damage (e.g., ischemia reperfusion injury) post-kidney transplantation (KT), the graft response to injury and repair involve changes in…2017 American Transplant Congress
Anti-CD40 mAb Promotes Kidney Immunoregulatory Capacity in NHP Transplants by Altering Kidney Tubular Cell (TEC) Expression of CD40 and IL-6.
Treatment of cynolmolgus monkey (NHP) renal transplant recipients with a combination of 2 rhesus-mouse chimeric α-CD45RB (r6G3R1; 6G3) and α-CD40 (r2C10R4; 2C10) mAbs increased circulating…2017 American Transplant Congress
A Mutation of the Erythropoietin Receptor Correlates with Improved Function of Deceased-Donor Renal Transplants.
Erythropoietin (Epo) protects renal tubular cells from ischemia/reperfusion injury in experimental transplantation, suggesting a relevant effect of erythropoietin receptor (EPOR) mediated signalling. Previously 6 mutations…2017 American Transplant Congress
Use of Hepatitis C Infected Organs for Kidney Transplantation: A Medical Decision Analysis.
1Dalhousie University, Halifax, NS, Canada; 2University of Alberta, Edmonton, AB, Canada
Given that Hepatitis C (HCV) can be cured, organs from HCV+ deceased donors might be used in HCV- recipients if treatment at the time of…2017 American Transplant Congress
Experience with Belatacept (CTLA4-Ig) Conversion in Highly HLA Sensitized (HS) and ABO-Incompatible (ABOi) Patients Who Received Incompatible Kidney Transplants Post Desensitization (DES).
Introduction: Recent experience with belatacept (bela) in nonsensitized kidney tx recipients suggest that costimulatory blockade in a CNI-free environment results in superior graft survival &…
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