Articles tagged "Kidney transplantation"

2018 American Transplant Congress
The Role of pDCs in Formation of Treg-Rich Organized Lymphoid Structures in Spontaneously Accepted Murine Kidney Allografts is Dependent on Mismatching of MHC Class II Molecules at the H2-I-A^b Locus
T. O'Shea,^1,2 C. Yang,¹ I. Rosales,² N. Oh,¹ D. Ndishibandi,^1,2 T. Ashry,¹ P. Russell,¹ J. Madsen,¹ R. Colvin,² A. Alessandrini.^1,2
¹Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA; ²Department of Pathology, Massachusetts General Hospital, Boston, MA.
Introduction: Our lab has demonstrated that murine kidney allografts are spontaneously accepted in specific donor-recipient strain combinations. Histologic examination of spontaneously accepted DBA/2J (DBA) kidneys…
2018 American Transplant Congress
The Brazilian Epitope Virtual Crossmatch Protocol: A Reliable Tool for Increasing Kidney Allocation among Highly Sensitized Patients
L. Sousa,¹ A. Silva,¹ M. Marroquim,¹ A. Coelho,¹ A. Lima,¹ F. Silva,¹ C. Carracosa,² G. Willcox,³ T. Leão,³ B. Correa,³ E. Guimarães,³ G. Maciel,³ J. Andrade,⁴ A. Andrade,⁴ R. Neto,⁴ S. Cavalcante,⁴ C. Leão,⁴ F. Cavalcante,⁵ A. Holanda,⁵ N. Gomes,⁶ A. Rego,⁶ S. Monte.¹
¹UFPI, Teresina, PI, Brazil; ²PUC, Curitiba, PR, Brazil; ³HLA Diagnostico, Recife, PE, Brazil; ⁴IMIP, Recife, PE, Brazil; ⁵RHP, Recife, PE, Brazil; ⁶CNCDO, Recife, PE, Brazil.
Background: In Brazil (BZ), the kidney allocation policy for highly sensitized patients (HS) (PRA ≥ 80%) does not involve prioritization and transplants 10 times less…
2018 American Transplant Congress
Many Highly Sensitized Candidates Still Waiting for Transplant Despite the Kidney Allocation System Change: Making the Case for Incompatible Transplantation
C. Schinstock, B. Smith, A. Bentall, M. Stegall.
Von Liebig Center for Transplantation and Clinical Regenerative Medicine, Mayo Clinic, Rochester, MN.
Introduction: The rate of kidney transplantation in highly sensitized individuals has increased since the kidney allocation system (KAS) change, but it remains unclear who has…
2018 American Transplant Congress
Effect of rATG on Monocytic Myeloid-Derived Suppressor Cells and Its Associated Mechanisms in Kidney Transplantation Recipients
Y. Jiang, X. Zhang.
Beijing Chao-Yang Hospital, Beijing, China.
Myeloid-derived suppressor cells (MDSCs) consist of heterogeneous myeloid progenitors and precursors that was first defined in cancer patients and are characterized by a regulatory ability…
2018 American Transplant Congress
Thymoglobulin Dose and Effect on Short-Term Kidney Transplant Outcomes
P. Sood, W. Christine, R. Mehta, A. Tevar, C. Puttarajappa, K. Schonder, K. Shimko, S. Hariharan.
University of Pitstburgh Medical Center, Pittsburgh.
Thymoglobulin is a commonly used induction agent for kidney transplantation. Optimal dosing for thymoglobulin is not well defined, and weight based dosing is often used.…
2018 American Transplant Congress
Graft Failure in Recurrent IgA Nephropathy Following Living Kidney Transplantation: Predictive Factors Analysis of 102 Biopsies
J. Zhang, J. Qiu, G. Chen, C. Wang, L. Chen.
Organ Transplant Unit, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Aim To investigate the predictive factors related to graft failure in recurrentIgA nephropathy (IgAN) following living kidney transplantation. Methods We identified a series of 102…
2018 American Transplant Congress
The Incidence and Risk Factors for Non – Adherence to Medical Treatment among Patients after Kidney Transplantation
T. Mashraki,^1,2,3 B. Rozen-Zvi,^1,4 E. Mor,^2,4 A. Yussim,^1,2 C. Avry,^1,4 R. Rahamimov.^1,2,3
¹Nephrology and Hypertension, Rabin Medical Center, Petach Tikva, Israel; ²Transplantation, Rabin Medical Center, Petach Tikva, Israel; ³Faculty of Health Science, Ariel University Center of Samaria, Ariel, Israel; ⁴Sackler Faculty of Medicine, Tel- Aviv University, Tel- Aviv, Israel.
Background: Nonadherence to medical treatment is an important risk factor for acute rejection and graft loss. In this study we sought to determine the prevalence…
2018 American Transplant Congress
Transplantation of Very Small Pediatric En Bloc Renal Allografts from Donors Less Than 8 Months of Age Have Similar Outcomes to Donors More Than 8 Months
S. Aquil,^1,2,3 N. Mitrou,^1,3 V. McAlister,^1,2,3 A. Sener,^1,2,3 P. Luke.^1,2,3
¹Departments of Surgery and Transplant, London Health Sciences Centre, University Hospital, London, ON, Canada; ²Microbiology and Immunology and Matthew Mailing Center for Transplant Studies, London Health Sciences Centre, University Hospital, London, ON, Canada; ³Departments of Surgery and Transplant, Western University, London, ON, Canada.
Purpose: Few programs use kidneys from donors with body weight (BW) less than 10 kg or less than 8 months of age, for fear of…
2018 American Transplant Congress
A Review of Pediatric Drug Development Programs and FDA Labeling for Immunosuppressive Drugs in Organ Transplant Patients
G. Burckart,¹ M. Cavaillé-Coll,² A. Duong,³ L. Hothem,⁴ R. Albrecht.²
¹Office of Clinical Pharmacology, Office of Translational Science, CDER, US Food and Drug Administration, Silver Spring, MD; ²Division of Transplant and Opthalmology Products, Office of New Drugs, CDER, US Food and Drug Administration, Silver Spring, MD; ³Tauro University, New York, NY; ⁴University of North Carolina, Chapel Hill, NC.
The development of drugs for organ transplantation spanned the time before and after pediatric regulatory requirements under the Best Pharmaceuticals for Children Act (BPCA) and…
2018 American Transplant Congress
Tumor Recurrence in Kidney Transplant Recipients with a History of Pretransplant Malignancy
F. Becker,¹ K. Schütte Nütgen,² S. Reuter,² L. Kebschull,¹ T. Vowinkel,¹ N. Senninger,¹ D. Palmes,¹ T. Vogel,¹ R. Bahde.¹
¹Department for General and Visceral Surgery, University Hospital Münster, Münster, Germany; ²Department of Internal Medicine D, University Hospital Münster, Münster, Germany.
Introduction: A growing body of evidence indicates that kidney transplant recipients (KTR) with a history of pre-transplant malignancy (PTM)have a higher incidence of post-transplant de-novo…