ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Tumor Recurrence in Kidney Transplant Recipients with a History of Pretransplant Malignancy

F. Becker,1 K. Schütte Nütgen,2 S. Reuter,2 L. Kebschull,1 T. Vowinkel,1 N. Senninger,1 D. Palmes,1 T. Vogel,1 R. Bahde.1

1Department for General and Visceral Surgery, University Hospital Münster, Münster, Germany
2Department of Internal Medicine D, University Hospital Münster, Münster, Germany.

Meeting: 2018 American Transplant Congress

Abstract number: B347

Keywords: Kidney transplantation, Malignancy

Session Information

Date: Sunday, June 3, 2018

Session Name: Poster Session B: PTLD/Malignancies: All Topics

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall 4EF

Related Abstracts
  • Pretransplant Elevated Plasma Fibrinogen Level Is Associated With Tumor Recurrence and Poor Prognosis in Hepatocellular Carcinoma Patients After Liver Transplantation
  • Effect of Embolization History and Tumor Treatment Response on Plasma TGFβ in HCC Patients Listed for Liver Transplantation.

Introduction: A growing body of evidence indicates that kidney transplant recipients (KTR) with a history of pre-transplant malignancy (PTM)have a higher incidence of post-transplant de-novo malignancies and are at high risk for post-transplant tumor recurrence. However, if a history of PTM affects graft specific outcomes remains unknown.

Methods: We retrospectively analyzed 1217 KTR (2000-2012) for PTM and assessed incidence of post-transplant tumor recurrence as well as post-transplant incidence of de-novo malignancies. In addition, we examined one- and five-year patient and graft survival, incidence of delayed graft function (DGF), acute rejections (AR) and estimated glomerular filtration rate (eGFR). To compare the results, we used two matched control groups similar in age, sex and time under immunosuppressive therapy or similar in age, sex and diagnosis of end-stage renal disease.

Results: We identified 65 KTR patients with a history of PTM; the most common ones being tumors of the urinary system (23%) and skin tumors (23%). The median time from tumor diagnosis to kidney transplantation was 105.55 months (range: 6-468). Of these 65 patients, three (4.6%) experienced tumor recurrence after a median of 34 months. Thirteen (20%) PTM patients developed a second de-novo malignancy, which was comparable to matched controls (n=9, 13.9%, p = 0.143). One- and five-year patient survival was 90.8% and 78.5%, respectively, and similar to matched controls.When comparing graft specific outcomes, we found similar frequencies for DGF, AR and comparable results for one- and five-year eGFR. However, one- and five-year graft survival were significantly decreased in patients with PTM compared to matched controls (nine [13.8%] vs. two [3.1%] deaths, and four [6.2%] vs. 15 deaths [23.1%], p = 0.039 and p =0.003, respectively).

Conclusion: The incidence of tumor recurrence in kidney transplant recipients with a history of PTM was 4.6% and 20% for second de-novo malignancies. Most important, we found a significant decrease in one- and five-year graft survival in PTM patients, independent of post-transplant malignancy. Possible explanations are an extended waiting period for PTM patients, which might increase the burden of co-morbidities or a selection bias when accepting grafts for PTM patients.

CITATION INFORMATION: Becker F., Schütte Nütgen K., Reuter S., Kebschull L., Vowinkel T., Senninger N., Palmes D., Vogel T., Bahde R. Tumor Recurrence in Kidney Transplant Recipients with a History of Pretransplant Malignancy Am J Transplant. 2017;17 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Becker F, Nütgen KSchütte, Reuter S, Kebschull L, Vowinkel T, Senninger N, Palmes D, Vogel T, Bahde R. Tumor Recurrence in Kidney Transplant Recipients with a History of Pretransplant Malignancy [abstract]. https://atcmeetingabstracts.com/abstract/tumor-recurrence-in-kidney-transplant-recipients-with-a-history-of-pretransplant-malignancy/. Accessed March 8, 2021.

« Back to 2018 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.